| mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation M Morita, SP Gravel, V Chénard, K Sikström, L Zheng, T Alain, V Gandin, ... Cell metabolism 18 (5), 698-711, 2013 | 874 | 2013 |
| mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs RJO Dowling, I Topisirovic, T Alain, M Bidinosti, BD Fonseca, ... Science 328 (5982), 1172-1176, 2010 | 854 | 2010 |
| SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate D Olagnier, E Farahani, J Thyrsted, J Blay-Cadanet, A Herengt, M Idorn, ... Nature communications 11 (1), 4938, 2020 | 412 | 2020 |
| Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence PM D'Aoust, E Mercier, D Montpetit, JJ Jia, I Alexandrov, N Neault, ... Water research 188, 116560, 2021 | 393 | 2021 |
| La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1) BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ... Journal of Biological Chemistry 290 (26), 15996-16020, 2015 | 299 | 2015 |
| Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3 N Robichaud, SV del Rincon, B Huor, T Alain, LA Petruccelli, J Hearnden, ... Oncogene 34 (16), 2032-2042, 2015 | 298 | 2015 |
| Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale V Gandin, K Sikström, T Alain, M Morita, S McLaughlan, O Larsson, ... Journal of visualized experiments: JoVE, 51455, 2014 | 243 | 2014 |
| Oncolytic reovirus against ovarian and colon cancer K Hirasawa, SG Nishikawa, KL Norman, T Alain, A Kossakowska, ... Cancer research 62 (6), 1696-1701, 2002 | 235 | 2002 |
| Distinct perturbation of the translatome by the antidiabetic drug metformin O Larsson, M Morita, I Topisirovic, T Alain, MJ Blouin, M Pollak, ... Proceedings of the National Academy of Sciences 109 (23), 8977-8982, 2012 | 234 | 2012 |
| A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ... Molecular and cellular biology, 2012 | 229 | 2012 |
| La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs RM Lahr, BD Fonseca, GE Ciotti, HA Al-Ashtal, JJ Jia, MR Niklaus, ... Elife 6, e24146, 2017 | 214 | 2017 |
| Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations PM D'Aoust, TE Graber, E Mercier, D Montpetit, I Alexandrov, N Neault, ... Science of the Total Environment 770, 145319, 2021 | 210 | 2021 |
| eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ... Cancer research 72 (24), 6468-6476, 2012 | 198 | 2012 |
| Myxoma virus is a novel oncolytic virus with significant antitumor activity against experimental human gliomas X Lun, W Yang, T Alain, ZQ Shi, H Muzik, JW Barrett, G McFadden, J Bell, ... Cancer research 65 (21), 9982-9990, 2005 | 193 | 2005 |
| Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling BD Fonseca, GH Diering, MA Bidinosti, K Dalal, T Alain, AD Balgi, ... Journal of Biological Chemistry 287 (21), 17530-17545, 2012 | 173 | 2012 |
| Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling R Cao, B Robinson, H Xu, C Gkogkas, A Khoutorsky, T Alain, A Yanagiya, ... Neuron 79 (4), 712-724, 2013 | 170 | 2013 |
| Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production T Alain, XQ Lun, Y Martineau, P Sean, B Pulendran, E Petroulakis, ... Proceedings of the National Academy of Sciences 107 (4), 1576-1581, 2010 | 166 | 2010 |
| Reovirus therapy of lymphoid malignancies T Alain, K Hirasawa, KJ Pon, SG Nishikawa, SJ Urbanski, Y Auer, J Luider, ... Blood, The Journal of the American Society of Hematology 100 (12), 4146-4153, 2002 | 148 | 2002 |
| Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma ST Beug, CE Beauregard, C Healy, T Sanda, M St-Jean, J Chabot, ... Nature Communications 8 (1), 14278, 2017 | 143 | 2017 |
| Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E B Herdy, M Jaramillo, YV Svitkin, AB Rosenfeld, M Kobayashi, D Walsh, ... Nature immunology 13 (6), 543-550, 2012 | 141 | 2012 |
Nahum SonenbergGilman Cheney Professor in BiochemistryVerified email at mcgill.ca
