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Santosh Thakkar
Santosh Thakkar
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Year
Impact of Residual Impurities and Contaminants on Protein Stability
W Wang, AA Ignatius, SV Thakkar
Journal of pharmaceutical sciences 103 (5), 1315-1330, 2014
1252014
Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium‐exchange mass …
P Manikwar, R Majumdar, JM Hickey, SV Thakkar, HS Samra, HA Sathish, ...
Journal of pharmaceutical sciences 102 (7), 2136-2151, 2013
1062013
Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies
SV Thakkar, SB Joshi, ME Jones, HA Sathish, SM Bishop, DB Volkin, ...
Journal of pharmaceutical sciences 101 (9), 3062-3077, 2012
732012
An industry perspective on forced degradation studies of biopharmaceuticals: survey outcome and recommendations
J Halley, YR Chou, C Cicchino, M Huang, V Sharma, NC Tan, S Thakkar, ...
Journal of pharmaceutical sciences 109 (1), 6-21, 2020
542020
An application of ultraviolet spectroscopy to study interactions in proteins solutions at high concentrations
SV Thakkar, KM Allegre, SB Joshi, DB Volkin, CR Middaugh
Journal of pharmaceutical sciences 101 (9), 3051-3061, 2012
512012
Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter
S Miyauchi, E Gopal, E Babu, SR Srinivas, Y Kubo, NS Umapathy, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1798 (6), 1164-1171, 2010
472010
Hyaluronic Acid Nanoparticles Titrate the Viscoelastic Properties of Viscosupplements
A Fakhari, Q Phan, SV Thakkar, CR Middaugh, C Berkland
Langmuir 29 (17), 5123-5131, 2013
382013
Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies
SV Thakkar, N Sahni, SB Joshi, BA Kerwin, F He, DB Volkin, ...
Protein Science 22 (10), 1295-1305, 2013
242013
Local dynamics and their alteration by excipients modulate the global conformational stability of an lgG1 monoclonal antibody
SV Thakkar, JH Kim, HS Samra, HA Sathish, SM Bishop, SB Joshi, ...
Journal of pharmaceutical sciences 101 (12), 4444-4457, 2012
232012
Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2‐fluorohistidine‐labeled analogue
L Hu, SB Joshi, KK Andra, SV Thakkar, DB Volkin, JG Bann, ...
Journal of pharmaceutical sciences 101 (11), 4118-4128, 2012
212012
Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells
PP Chothe, SV Thakkar, JP Gnana-Prakasam, S Ananth, DR Hinton, ...
Investigative Ophthalmology & Visual Science 51 (1), 413-420, 2010
192010
Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2
SV THAKKAR, S MIYAUCHI, PD PRASAD, V GANAPATHY
Drug metabolism and pharmacokinetics 23 (4), 254-262, 2008
182008
Product-specific impact of viscosity modulating formulation excipients during ultra-high concentration biotherapeutics drug product development
D Rodrigues, LM Tanenbaum, R Thirumangalathu, S Somani, K Zhang, ...
Journal of Pharmaceutical Sciences 110 (3), 1077-1082, 2021
152021
Toward biotherapeutics formulation composition Engineering using site-identification by ligand competitive saturation (SILCS)
S Somani, S Jo, R Thirumangalathu, D Rodrigues, LM Tanenbaum, ...
Journal of Pharmaceutical Sciences 110 (3), 1103-1110, 2021
142021
Transport of the synthetic opioid peptide DADLE ([d‐Ala2, d‐Leu5]–Enkephalin) in neuronal cells
S Ananth, SV Thakkar, JP Gnana‐prakasam, PM Martin, PS Ganapathy, ...
Journal of pharmaceutical sciences 101 (1), 154-163, 2012
142012
Differential modulation of sodium-and chloride-dependent opioid peptide transport system by small nonopioid peptides and free amino acids
S Miyauchi, E Gopal, SV Thakkar, S Ichikawa, PD Prasad, V Ganapathy
Journal of Pharmacology and Experimental Therapeutics 321 (1), 257-264, 2007
132007
Spectrophotometric estimation of sildenafil citrate in tablets
BS Kuchekar, SV Thakkar, PP Chothe, MR Hiremath, DB Shinde
Indian journal of pharmaceutical sciences 67 (6), 749-751, 2005
122005
A formulation method to improve the physical stability of macromolecular-based drug products
A Bhambhani, S Thakkar, SB Joshi, CR Middaugh
Therapeutic Protein Drug Products, 13-45, 2012
102012
Spectrophotometric estimation of clozapine in tablets
BS Kuchekar, YN Gavhane, NB Gaikwad, SV Thakkar
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH 40 (3), 203, 2006
92006
Spectrophotometric estimation of melatonin and pyridoxine hydrochloride in combined dosage forms
BS Kuchekar, SV Thakkar, MR Hiremath, PP Chothe, DB Shinde
Indian journal of pharmaceutical sciences 64 (2), 158-160, 2002
62002
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