Impact of Residual Impurities and Contaminants on Protein Stability W Wang, AA Ignatius, SV Thakkar Journal of pharmaceutical sciences 103 (5), 1315-1330, 2014 | 125 | 2014 |
Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium‐exchange mass … P Manikwar, R Majumdar, JM Hickey, SV Thakkar, HS Samra, HA Sathish, ... Journal of pharmaceutical sciences 102 (7), 2136-2151, 2013 | 106 | 2013 |
Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies SV Thakkar, SB Joshi, ME Jones, HA Sathish, SM Bishop, DB Volkin, ... Journal of pharmaceutical sciences 101 (9), 3062-3077, 2012 | 73 | 2012 |
An industry perspective on forced degradation studies of biopharmaceuticals: survey outcome and recommendations J Halley, YR Chou, C Cicchino, M Huang, V Sharma, NC Tan, S Thakkar, ... Journal of pharmaceutical sciences 109 (1), 6-21, 2020 | 54 | 2020 |
An application of ultraviolet spectroscopy to study interactions in proteins solutions at high concentrations SV Thakkar, KM Allegre, SB Joshi, DB Volkin, CR Middaugh Journal of pharmaceutical sciences 101 (9), 3051-3061, 2012 | 51 | 2012 |
Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter S Miyauchi, E Gopal, E Babu, SR Srinivas, Y Kubo, NS Umapathy, ... Biochimica et Biophysica Acta (BBA)-Biomembranes 1798 (6), 1164-1171, 2010 | 47 | 2010 |
Hyaluronic Acid Nanoparticles Titrate the Viscoelastic Properties of Viscosupplements A Fakhari, Q Phan, SV Thakkar, CR Middaugh, C Berkland Langmuir 29 (17), 5123-5131, 2013 | 38 | 2013 |
Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies SV Thakkar, N Sahni, SB Joshi, BA Kerwin, F He, DB Volkin, ... Protein Science 22 (10), 1295-1305, 2013 | 24 | 2013 |
Local dynamics and their alteration by excipients modulate the global conformational stability of an lgG1 monoclonal antibody SV Thakkar, JH Kim, HS Samra, HA Sathish, SM Bishop, SB Joshi, ... Journal of pharmaceutical sciences 101 (12), 4444-4457, 2012 | 23 | 2012 |
Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2‐fluorohistidine‐labeled analogue L Hu, SB Joshi, KK Andra, SV Thakkar, DB Volkin, JG Bann, ... Journal of pharmaceutical sciences 101 (11), 4118-4128, 2012 | 21 | 2012 |
Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells PP Chothe, SV Thakkar, JP Gnana-Prakasam, S Ananth, DR Hinton, ... Investigative Ophthalmology & Visual Science 51 (1), 413-420, 2010 | 19 | 2010 |
Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2 SV THAKKAR, S MIYAUCHI, PD PRASAD, V GANAPATHY Drug metabolism and pharmacokinetics 23 (4), 254-262, 2008 | 18 | 2008 |
Product-specific impact of viscosity modulating formulation excipients during ultra-high concentration biotherapeutics drug product development D Rodrigues, LM Tanenbaum, R Thirumangalathu, S Somani, K Zhang, ... Journal of Pharmaceutical Sciences 110 (3), 1077-1082, 2021 | 15 | 2021 |
Toward biotherapeutics formulation composition Engineering using site-identification by ligand competitive saturation (SILCS) S Somani, S Jo, R Thirumangalathu, D Rodrigues, LM Tanenbaum, ... Journal of Pharmaceutical Sciences 110 (3), 1103-1110, 2021 | 14 | 2021 |
Transport of the synthetic opioid peptide DADLE ([d‐Ala2, d‐Leu5]–Enkephalin) in neuronal cells S Ananth, SV Thakkar, JP Gnana‐prakasam, PM Martin, PS Ganapathy, ... Journal of pharmaceutical sciences 101 (1), 154-163, 2012 | 14 | 2012 |
Differential modulation of sodium-and chloride-dependent opioid peptide transport system by small nonopioid peptides and free amino acids S Miyauchi, E Gopal, SV Thakkar, S Ichikawa, PD Prasad, V Ganapathy Journal of Pharmacology and Experimental Therapeutics 321 (1), 257-264, 2007 | 13 | 2007 |
Spectrophotometric estimation of sildenafil citrate in tablets BS Kuchekar, SV Thakkar, PP Chothe, MR Hiremath, DB Shinde Indian journal of pharmaceutical sciences 67 (6), 749-751, 2005 | 12 | 2005 |
A formulation method to improve the physical stability of macromolecular-based drug products A Bhambhani, S Thakkar, SB Joshi, CR Middaugh Therapeutic Protein Drug Products, 13-45, 2012 | 10 | 2012 |
Spectrophotometric estimation of clozapine in tablets BS Kuchekar, YN Gavhane, NB Gaikwad, SV Thakkar INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH 40 (3), 203, 2006 | 9 | 2006 |
Spectrophotometric estimation of melatonin and pyridoxine hydrochloride in combined dosage forms BS Kuchekar, SV Thakkar, MR Hiremath, PP Chothe, DB Shinde Indian journal of pharmaceutical sciences 64 (2), 158-160, 2002 | 6 | 2002 |