| αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells PG Sreekumar, R Kannan, M Kitamura, C Spee, E Barron, SJ Ryan, ... PloS one 5 (10), e12578, 2010 | 227 | 2010 |
| The mitochondrial-derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction PG Sreekumar, K Ishikawa, C Spee, HH Mehta, J Wan, K Yen, P Cohen, ... Investigative ophthalmology & visual science 57 (3), 1238-1253, 2016 | 177 | 2016 |
| Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. R Kannan, N Zhang, PG Sreekumar, CK Spee, A Rodriguez, E Barron, ... Molecular vision 12, 1649-1659, 2006 | 161 | 2006 |
| Novel roles for α-crystallins in retinal function and disease R Kannan, PG Sreekumar, DR Hinton Progress in retinal and eye research 31 (6), 576-604, 2012 | 126 | 2012 |
| Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration S Sonoda, PG Sreekumar, S Kase, C Spee, SJ Ryan, R Kannan, ... Aging (Albany NY) 2 (1), 28, 2010 | 105 | 2010 |
| Protection of retina by αB crystallin in sodium iodate induced retinal degeneration P Zhou, R Kannan, C Spee, PG Sreekumar, G Dou, DR Hinton PloS one 9 (5), e98275, 2014 | 86 | 2014 |
| Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction G Dou, PG Sreekumar, C Spee, S He, SJ Ryan, R Kannan, DR Hinton Free Radical Biology and Medicine 53 (5), 1111-1122, 2012 | 85 | 2012 |
| Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia J Yaung, R Kannan, EF Wawrousek, C Spee, PG Sreekumar, DR Hinton Experimental eye research 86 (2), 355-365, 2008 | 78 | 2008 |
| Protective mechanisms of the mitochondrial‐derived peptide humanin in oxidative and endoplasmic reticulum stress in RPE cells L Minasyan, PG Sreekumar, DR Hinton, R Kannan Oxidative medicine and cellular longevity 2017 (1), 1675230, 2017 | 76 | 2017 |
| Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration R Kannan, PG Sreekumar, DR Hinton Biochimica et Biophysica Acta (BBA)-General Subjects 1860 (1), 258-268, 2016 | 75 | 2016 |
| Protection from oxidative stress by methionine sulfoxide reductases in RPE cells PG Sreekumar, R Kannan, J Yaung, CK Spee, SJ Ryan, DR Hinton Biochemical and Biophysical Research Communications 334 (1), 245-253, 2005 | 75 | 2005 |
| Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux PG Sreekumar, C Spee, SJ Ryan, SPC Cole, R Kannan, DR Hinton PLoS One 7 (3), e33420, 2012 | 67 | 2012 |
| Glutathione metabolism and the novel role of mitochondrial GSH in retinal degeneration PG Sreekumar, DA Ferrington, R Kannan Antioxidants 10 (5), 661, 2021 | 66 | 2021 |
| Humanin protects RPE cells from endoplasmic reticulum stress-induced apoptosis by upregulation of mitochondrial glutathione D Matsunaga, PG Sreekumar, K Ishikawa, H Terasaki, E Barron, P Cohen, ... PloS one 11 (10), e0165150, 2016 | 65 | 2016 |
| Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells W Wang, PG Sreekumar, V Valluripalli, P Shi, J Wang, YA Lin, H Cui, ... Journal of Controlled Release 191, 4-14, 2014 | 60 | 2014 |
| Antiapoptotic properties of α-crystallin–derived peptide chaperones and characterization of their uptake transporters in human RPE cells PG Sreekumar, P Chothe, KK Sharma, R Baid, U Kompella, C Spee, ... Investigative ophthalmology & visual science 54 (4), 2787-2798, 2013 | 59 | 2013 |
| αB-crystallin regulates subretinal fibrosis by modulation of epithelial-mesenchymal transition K Ishikawa, PG Sreekumar, C Spee, H Nazari, D Zhu, R Kannan, ... The American journal of pathology 186 (4), 859-873, 2016 | 56 | 2016 |
| The emerging role of senescence in ocular disease PG Sreekumar, DR Hinton, R Kannan Oxidative medicine and cellular longevity 2020 (1), 2583601, 2020 | 55 | 2020 |
| Intra-vitreal αB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration PG Sreekumar, Z Li, W Wang, C Spee, DR Hinton, R Kannan, JA MacKay Journal of Controlled Release 283, 94-104, 2018 | 49 | 2018 |
| Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells PG Sreekumar, R Kannan, AT de Silva, R Burton, SJ Ryan, DR Hinton Biochemical and biophysical research communications 346 (4), 1200-1206, 2006 | 43 | 2006 |
Ram Kannan, Ramaswamy Kannan, R...UCLA, VA Wadsworth Hospital West Los Angeles, USC Ophthalmology, Doheny Eye InstituteVerified email at doheny.org
