| PD-1 inhibitory receptor downregulates asparaginyl endopeptidase and maintains Foxp3 transcription factor stability in induced regulatory T cells C Stathopoulou, A Gangaplara, G Mallett, FA Flomerfelt, LP Liniany, ... Immunity 49 (2), 247-263. e7, 2018 | 139 | 2018 |
| Structural and functional analysis of novel human cytochrome c targets in apoptosis J Martínez-Fábregas, I Díaz-Moreno, K Gonzalez-Arzola, S Janocha, ... Molecular & Cellular Proteomics 13 (6), 1439-1456, 2014 | 102 | 2014 |
| New Arabidopsis thaliana cytochrome c partners: a look into the elusive role of cytochrome c in programmed cell death in plants J Martínez-Fábregas, I Díaz-Moreno, K González-Arzola, S Janocha, ... Molecular & Cellular Proteomics 12 (12), 3666-3676, 2013 | 65 | 2013 |
| Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis J Martínez-Fábregas, A Prescott, S van Kasteren, DL Pedrioli, I McLean, ... Nature Communications 9 (1), 5343, 2018 | 61 | 2018 |
| IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein S Gaggero, J Martinez-Fabregas, A Cozzani, PK Fyfe, M Leprohon, ... Science immunology 7 (78), eade5686, 2022 | 50 | 2022 |
| A common signalosome for programmed cell death in humans and plants J Martínez-Fábregas, I Díaz-Moreno, K González-Arzola, A Díaz-Quintana, ... Cell death & disease 5 (7), e1314-e1314, 2014 | 50 | 2014 |
| Kinetics of cytokine receptor trafficking determine signaling and functional selectivity J Martinez-Fabregas, S Wilmes, L Wang, M Hafer, E Pohler, J Lokau, ... Elife 8, e49314, 2019 | 42 | 2019 |
| CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci J Martinez-Fabregas, L Wang, E Pohler, A Cozzani, S Wilmes, ... Cell reports 33 (12), 2020 | 32 | 2020 |
| Mapping determinants of cytokine signaling via protein engineering C Gorby, J Martinez-Fabregas, S Wilmes, I Moraga Frontiers in immunology 9, 2143, 2018 | 32 | 2018 |
| Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase separation K González-Arzola, A Díaz-Quintana, N Bernardo-García, ... Nature structural & molecular biology 29 (10), 1024-1036, 2022 | 24 | 2022 |
| Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses S Wilmes, PA Jeffrey, J Martinez-Fabregas, M Hafer, PK Fyfe, E Pohler, ... Elife 10, e66014, 2021 | 22 | 2021 |
| Proteomic tools for the analysis of transient interactions between metalloproteins J Martínez‐Fábregas, S Rubio, A Díaz‐Quintana, I Díaz‐Moreno, ... The FEBS journal 278 (9), 1401-1410, 2011 | 20 | 2011 |
| Lysosomes: multifunctional compartments ruled by a complex regulatory network J Martinez‐Fabregas, J Tamargo‐Azpilicueta, I Diaz‐Moreno FEBS Open bio 12 (4), 758-774, 2022 | 5 | 2022 |
| A common role for cytochrome c in programmed cell death in humans and plants K Gonzalez-Arzola, B Moreno-Beltran, J Martinez-Fabregas, ... Protein Science 24, 259-260, 2015 | 2 | 2015 |
| Programmed death-1 receptor signaling downregulates asparaginyl endopeptidase to maintain Foxp3 stability in induced Regulatory T cells C Stathopoulou, A Gangaplara, G Mallett, FA Flomerfelt, LP Liniany, ... Immunity 49 (2), 247, 2018 | 1 | 2018 |
| A Common Cytochrome c‐centred Signalosome for Programmed Cell Death in Humans and Plants M De la Rosa, K Gonzalez‐Arzola, J Martinez‐Fabregas, ... The FASEB Journal 29, 569.13, 2015 | 1 | 2015 |
| Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer M Morillo-Huesca, I G. López-Cepero, R Conesa-Bakkali, M Tomé, ... Journal of Experimental & Clinical Cancer Research 44 (1), 74, 2025 | | 2025 |
| Non-Canonical, Extralysosomal Activities of Lysosomal Peptidases in Physiological and Pathological Conditions: New Clinical Opportunities for Cancer Therapy R Conesa-Bakkali, M Morillo-Huesca, J Martínez-Fábregas Cells 14 (2), 68, 2025 | | 2025 |
| Asparagine endopeptidase promotes radioresistance in breast cancer through ATR pathway modulation M Morillo-Huesca, M Tome, C Watts, P Huertas, G Moreno-Bueno, ... bioRxiv, 2025.01. 13.632704, 2025 | | 2025 |
| Funciones emergentes de las proteasas lisosomales en la regulación de procesos tumorales. M Acosta Armas, J Martínez Fábregas | | 2023 |
