| Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth T Hitosugi, S Kang, MG Vander Heiden, TW Chung, S Elf, K Lythgoe, ... Science signaling 2 (97), ra73-ra73, 2009 | 861 | 2009 |
| Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth T Hitosugi, L Zhou, S Elf, J Fan, HB Kang, JH Seo, C Shan, Q Dai, ... Cancer cell 22 (5), 585-600, 2012 | 445 | 2012 |
| Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism T Hitosugi, J Fan, TW Chung, K Lythgoe, X Wang, J Xie, Q Ge, TL Gu, ... Molecular cell 44 (6), 864-877, 2011 | 349 | 2011 |
| Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex J Fan, C Shan, HB Kang, S Elf, J Xie, M Tucker, TL Gu, M Aguiar, ... Molecular cell 53 (4), 534-548, 2014 | 298 | 2014 |
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling R Lin, S Elf, C Shan, HB Kang, Q Ji, L Zhou, T Hitosugi, L Zhang, S Zhang, ... Nature cell biology 17 (11), 1484-1496, 2015 | 282 | 2015 |
| Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD+ redox homeostasis in cancer cells J Fan, T Hitosugi, TW Chung, J Xie, Q Ge, TL Gu, RD Polakiewicz, ... Molecular and cellular biology, 2011 | 268 | 2011 |
| The transcription factor Bhlhe40 programs mitochondrial regulation of resident CD8+ T cell fitness and functionality C Li, B Zhu, YM Son, Z Wang, L Jiang, M Xiang, Z Ye, KE Beckermann, ... Immunity 51 (3), 491-507. e7, 2019 | 208 | 2019 |
| p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells S Kang, S Elf, K Lythgoe, T Hitosugi, J Taunton, W Zhou, L Xiong, D Wang, ... The Journal of clinical investigation 120 (4), 1165-1177, 2010 | 181 | 2010 |
| Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth C Shan, S Elf, Q Ji, HB Kang, L Zhou, T Hitosugi, L Jin, R Lin, L Zhang, ... Molecular cell 55 (4), 552-565, 2014 | 149 | 2014 |
| Post-translational modifications and the Warburg effect T Hitosugi, J Chen Oncogene 33 (34), 4279-4285, 2014 | 137 | 2014 |
| Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia X Zhang, AM Saarinen, T Hitosugi, Z Wang, L Wang, TH Ho, J Liu Elife 6, e31132, 2017 | 132 | 2017 |
| Carnitine palmitoyltransferase 1A has a lysine succinyltransferase activity K Kurmi, S Hitosugi, EK Wiese, F Boakye-Agyeman, WI Gonsalves, Z Lou, ... Cell reports 22 (6), 1365-1373, 2018 | 111 | 2018 |
| Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation T Hitosugi, L Zhou, J Fan, S Elf, L Zhang, J Xie, Y Wang, TL Gu, ... Nature communications 4 (1), 1790, 2013 | 104 | 2013 |
| Enzymatic and metabolic regulation of lysine succinylation A Sreedhar, EK Wiese, T Hitosugi Genes & diseases 7 (2), 166-171, 2020 | 86 | 2020 |
| Tyrosine kinase signaling in cancer metabolism: PKM2 paradox in the Warburg effect EK Wiese, T Hitosugi Frontiers in cell and developmental biology 6, 79, 2018 | 80 | 2018 |
| Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation S Kang, S Elf, S Dong, T Hitosugi, K Lythgoe, A Guo, H Ruan, S Lonial, ... Molecular and cellular biology 29 (8), 2105-2117, 2009 | 79 | 2009 |
| Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth C Shan, HB Kang, S Elf, J Xie, TL Gu, M Aguiar, S Lonning, T Hitosugi, ... Journal of Biological Chemistry 289 (31), 21413-21422, 2014 | 72 | 2014 |
| Tyrosine phosphorylation of mitochondrial creatine kinase 1 enhances a druggable tumor energy shuttle pathway K Kurmi, S Hitosugi, J Yu, F Boakye-Agyeman, EK Wiese, TR Larson, ... Cell metabolism 28 (6), 833-847. e8, 2018 | 69 | 2018 |
| Lipid Raft–Specific Knockdown of Src Family Kinase Activity Inhibits Cell Adhesion and Cell Cycle Progression of Breast Cancer Cells T Hitosugi, M Sato, K Sasaki, Y Umezawa Cancer research 67 (17), 8139-8148, 2007 | 59 | 2007 |
| BRCA1 deficiency upregulates NNMT, which reprograms metabolism and sensitizes ovarian cancer cells to mitochondrial metabolic targeting agents A Kanakkanthara, K Kurmi, TL Ekstrom, X Hou, ER Purfeerst, EP Heinzen, ... Cancer research 79 (23), 5920-5929, 2019 | 58 | 2019 |
