PET/MRI in head and neck cancer: initial experience I Platzek, B Beuthien-Baumann, M Schneider, V Gudziol, J Langner, ... European journal of nuclear medicine and molecular imaging 40, 6-11, 2013 | 167* | 2013 |
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase … OM Bautista-Aguilera, G Esteban, I Bolea, K Nikolic, D Agbaba, ... European journal of medicinal chemistry 75, 82-95, 2014 | 161 | 2014 |
Donepezil+ propargylamine+ 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease L Wang, G Esteban, M Ojima, OM Bautista-Aguilera, T Inokuchi, ... European journal of medicinal chemistry 80, 543-561, 2014 | 147 | 2014 |
Flecainide increases Kir2. 1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification R Caballero, P Dolz-Gaitón, R Gómez, I Amorós, A Barana, ... Proceedings of the National Academy of Sciences 107 (35), 15631-15636, 2010 | 107 | 2010 |
Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases ÓM Bautista‐Aguilera, S Hagenow, A Palomino‐Antolin, V Farré‐Alins, ... Angewandte Chemie International Edition 56 (41), 12765-12769, 2017 | 98 | 2017 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase ED AlFadly, PA Elzahhar, A Tramarin, S Elkazaz, H Shaltout, ... European journal of medicinal chemistry 167, 161-186, 2019 | 97 | 2019 |
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted … A Samadi, C De Los Ríos, I Bolea, M Chioua, I Iriepa, I Moraleda, ... European journal of medicinal chemistry 52, 251-262, 2012 | 91 | 2012 |
Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer’s disease A Samadi, M Chioua, I Bolea, C De Los Ríos, I Iriepa, I Moraleda, ... European journal of medicinal chemistry 46 (9), 4665-4668, 2011 | 85 | 2011 |
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1, 8-naphthyridine derivatives C De Los Ríos, J Egea, J Marco-Contelles, R León, A Samadi, I Iriepa, ... Journal of medicinal chemistry 53 (14), 5129-5143, 2010 | 83 | 2010 |
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9, 10, 11, 12-tetrahydro-7H-benzo [7, 8] chromeno [2, 3-b] quinolin-8-amines as potential drugs for … E Maalej, F Chabchoub, MJ Oset-Gasque, M Esquivias-Pérez, ... European journal of medicinal chemistry 54, 750-763, 2012 | 80 | 2012 |
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR … OM Bautista-Aguilera, G Esteban, M Chioua, K Nikolic, D Agbaba, ... Drug Design, Development and Therapy, 1893-1910, 2014 | 77 | 2014 |
Harmaline and hispidin from Peganum harmala and Inonotus hispidus with binding affinity to Candida rugosa lipase: In silico and in vitro studies K Benarous, I Bombarda, I Iriepa, I Moraleda, H Gaetan, A Linani, D Tahri, ... Bioorganic chemistry 62, 1-7, 2015 | 67 | 2015 |
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling A Samadi, M Estrada, C Pérez, MI Rodríguez-Franco, I Iriepa, I Moraleda, ... European journal of medicinal chemistry 57, 296-301, 2012 | 67 | 2012 |
Synthesis and biological assessment of diversely substituted furo [2, 3-b] quinolin-4-amine and pyrrolo [2, 3-b] quinolin-4-amine derivatives, as novel tacrine analogues C Martins, MC Carreiras, R León, C De Los Ríos, M Bartolini, V Andrisano, ... European journal of medicinal chemistry 46 (12), 6119-6130, 2011 | 63 | 2011 |
Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease N García-Font, H Hayour, A Belfaitah, J Pedraz, I Moraleda, I Iriepa, ... European journal of medicinal chemistry 118, 178-192, 2016 | 60 | 2016 |
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease M Chioua, E Buzzi, I Moraleda, I Iriepa, M Maj, A Wnorowski, C Giovannini, ... European Journal of Medicinal Chemistry 155, 839-846, 2018 | 58 | 2018 |
Contilisant, a tetratarget small molecule for Alzheimer’s disease therapy combining cholinesterase, monoamine oxidase inhibition, and H3R antagonism with S1R agonism profile OM Bautista-Aguilera, J Budni, F Mina, EB Medeiros, W Deuther-Conrad, ... Journal of medicinal chemistry 61 (15), 6937-6943, 2018 | 58 | 2018 |
Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity D Silva, M Chioua, A Samadi, P Agostinho, P Garcao, R Lajarín-Cuesta, ... ACS Chemical Neuroscience 4 (4), 547-565, 2013 | 57 | 2013 |
Donepezil+ chromone+ melatonin hybrids as promising agents for Alzheimer’s disease therapy I Pachón-Angona, B Refouvelet, R Andrýs, H Martin, V Luzet, I Iriepa, ... Journal of Enzyme Inhibition and Medicinal Chemistry 34 (1), 479-489, 2019 | 54 | 2019 |
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment S Montanari, AM Mahmoud, L Pruccoli, A Rabbito, M Naldi, S Petralla, ... European Journal of Medicinal Chemistry 178, 243-258, 2019 | 49 | 2019 |