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Ignacio Moraleda Fernández
Ignacio Moraleda Fernández
Quimica Orgánica, Universidad Alcalá
Verified email at uah.es
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Cited by
Cited by
Year
PET/MRI in head and neck cancer: initial experience
I Platzek, B Beuthien-Baumann, M Schneider, V Gudziol, J Langner, ...
European journal of nuclear medicine and molecular imaging 40, 6-11, 2013
167*2013
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase …
OM Bautista-Aguilera, G Esteban, I Bolea, K Nikolic, D Agbaba, ...
European journal of medicinal chemistry 75, 82-95, 2014
1612014
Donepezil+ propargylamine+ 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease
L Wang, G Esteban, M Ojima, OM Bautista-Aguilera, T Inokuchi, ...
European journal of medicinal chemistry 80, 543-561, 2014
1472014
Flecainide increases Kir2. 1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification
R Caballero, P Dolz-Gaitón, R Gómez, I Amorós, A Barana, ...
Proceedings of the National Academy of Sciences 107 (35), 15631-15636, 2010
1072010
Multitarget‐Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3R Antagonism for Neurodegenerative Diseases
ÓM Bautista‐Aguilera, S Hagenow, A Palomino‐Antolin, V Farré‐Alins, ...
Angewandte Chemie International Edition 56 (41), 12765-12769, 2017
982017
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
ED AlFadly, PA Elzahhar, A Tramarin, S Elkazaz, H Shaltout, ...
European journal of medicinal chemistry 167, 161-186, 2019
972019
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted …
A Samadi, C De Los Ríos, I Bolea, M Chioua, I Iriepa, I Moraleda, ...
European journal of medicinal chemistry 52, 251-262, 2012
912012
Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer’s disease
A Samadi, M Chioua, I Bolea, C De Los Ríos, I Iriepa, I Moraleda, ...
European journal of medicinal chemistry 46 (9), 4665-4668, 2011
852011
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1, 8-naphthyridine derivatives
C De Los Ríos, J Egea, J Marco-Contelles, R León, A Samadi, I Iriepa, ...
Journal of medicinal chemistry 53 (14), 5129-5143, 2010
832010
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9, 10, 11, 12-tetrahydro-7H-benzo [7, 8] chromeno [2, 3-b] quinolin-8-amines as potential drugs for …
E Maalej, F Chabchoub, MJ Oset-Gasque, M Esquivias-Pérez, ...
European journal of medicinal chemistry 54, 750-763, 2012
802012
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR …
OM Bautista-Aguilera, G Esteban, M Chioua, K Nikolic, D Agbaba, ...
Drug Design, Development and Therapy, 1893-1910, 2014
772014
Harmaline and hispidin from Peganum harmala and Inonotus hispidus with binding affinity to Candida rugosa lipase: In silico and in vitro studies
K Benarous, I Bombarda, I Iriepa, I Moraleda, H Gaetan, A Linani, D Tahri, ...
Bioorganic chemistry 62, 1-7, 2015
672015
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling
A Samadi, M Estrada, C Pérez, MI Rodríguez-Franco, I Iriepa, I Moraleda, ...
European journal of medicinal chemistry 57, 296-301, 2012
672012
Synthesis and biological assessment of diversely substituted furo [2, 3-b] quinolin-4-amine and pyrrolo [2, 3-b] quinolin-4-amine derivatives, as novel tacrine analogues
C Martins, MC Carreiras, R León, C De Los Ríos, M Bartolini, V Andrisano, ...
European journal of medicinal chemistry 46 (12), 6119-6130, 2011
632011
Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease
N García-Font, H Hayour, A Belfaitah, J Pedraz, I Moraleda, I Iriepa, ...
European journal of medicinal chemistry 118, 178-192, 2016
602016
Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease
M Chioua, E Buzzi, I Moraleda, I Iriepa, M Maj, A Wnorowski, C Giovannini, ...
European Journal of Medicinal Chemistry 155, 839-846, 2018
582018
Contilisant, a tetratarget small molecule for Alzheimer’s disease therapy combining cholinesterase, monoamine oxidase inhibition, and H3R antagonism with S1R agonism profile
OM Bautista-Aguilera, J Budni, F Mina, EB Medeiros, W Deuther-Conrad, ...
Journal of medicinal chemistry 61 (15), 6937-6943, 2018
582018
Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity
D Silva, M Chioua, A Samadi, P Agostinho, P Garcao, R Lajarín-Cuesta, ...
ACS Chemical Neuroscience 4 (4), 547-565, 2013
572013
Donepezil+ chromone+ melatonin hybrids as promising agents for Alzheimer’s disease therapy
I Pachón-Angona, B Refouvelet, R Andrýs, H Martin, V Luzet, I Iriepa, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 34 (1), 479-489, 2019
542019
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
S Montanari, AM Mahmoud, L Pruccoli, A Rabbito, M Naldi, S Petralla, ...
European Journal of Medicinal Chemistry 178, 243-258, 2019
492019
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