| The target landscape of clinical kinase drugs S Klaeger, S Heinzlmeir, M Wilhelm, H Polzer, B Vick, PA Koenig, ... Science 358 (6367), eaan4368, 2017 | 812 | 2017 |
| DMSO enhances electrospray response, boosting sensitivity of proteomic experiments H Hahne, F Pachl, B Ruprecht, SK Maier, S Klaeger, D Helm, G Médard, ... Nature methods 10 (10), 989-991, 2013 | 256 | 2013 |
| The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice A Kindt, G Liebisch, T Clavel, D Haller, G Hörmannsperger, H Yoon, ... Nature communications 9 (1), 3760, 2018 | 248 | 2018 |
| Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP S Sridharan, N Kurzawa, T Werner, I Guenthner, D Helm, W Huber, ... Nature communications 10 (1), 1155, 2019 | 228 | 2019 |
| Pervasive protein thermal stability variation during the cell cycle I Becher, A Andrés-Pons, N Romanov, F Stein, M Schramm, F Baudin, ... Cell 173 (6), 1495-1507. e18, 2018 | 221 | 2018 |
| Thermal proteome profiling for interrogating protein interactions A Mateus, N Kurzawa, I Becher, S Sridharan, D Helm, F Stein, A Typas, ... Molecular systems biology 16 (3), e9232, 2020 | 206 | 2020 |
| Proteome wide purification and identification of O-GlcNAc modified proteins using Click chemistry and mass spectrometry H Hahne, N Sobotzki, T Nyberg, D Helm, VS Borodkin, DM van Aalten, ... Journal of proteome research, 2013 | 187 | 2013 |
| Thermal proteome profiling in bacteria: probing protein state in vivo A Mateus, J Bobonis, N Kurzawa, F Stein, D Helm, J Hevler, A Typas, ... Molecular systems biology 14 (7), e8242, 2018 | 173 | 2018 |
| Optimized chemical proteomics assay for kinase inhibitor profiling G Médard, F Pachl, B Ruprecht, S Klaeger, S Heinzlmeir, D Helm, H Qiao, ... Journal of proteome research 14 (3), 1574-1586, 2015 | 149 | 2015 |
| Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics D Helm, JPC Vissers, CJ Hughes, H Hahne, B Ruprecht, F Pachl, A Grzyb, ... Molecular & Cellular Proteomics 13 (12), 3709-3715, 2014 | 127 | 2014 |
| moCluster: identifying joint patterns across multiple omics data sets C Meng, D Helm, M Frejno, B Kuster Journal of proteome research 15 (3), 755-765, 2016 | 119 | 2016 |
| Chemical proteomics reveals ferrochelatase as a common off-target of kinase inhibitors S Klaeger, B Gohlke, J Perrin, V Gupta, S Heinzlmeir, D Helm, H Qiao, ... ACS chemical biology 11 (5), 1245-1254, 2016 | 100 | 2016 |
| The functional proteome landscape of Escherichia coli A Mateus, J Hevler, J Bobonis, N Kurzawa, M Shah, K Mitosch, ... Nature 588 (7838), 473-478, 2020 | 88 | 2020 |
| A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver D Inverso, J Shi, KH Lee, M Jakab, S Ben-Moshe, SR Kulkarni, ... Developmental cell 56 (11), 1677-1693. e10, 2021 | 79 | 2021 |
| Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly E Ratto, SR Chowdhury, NS Siefert, M Schneider, M Wittmann, D Helm, ... Nature communications 13 (1), 4848, 2022 | 69 | 2022 |
| The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range H Girstmair, F Tippel, A Lopez, K Tych, F Stein, P Haberkant, ... Nature communications 10 (1), 3626, 2019 | 66 | 2019 |
| Proteome activity landscapes of tumor cell lines determine drug responses M Frejno, C Meng, B Ruprecht, T Oellerich, S Scheich, K Kleigrewe, ... Nature communications 11 (1), 3639, 2020 | 64 | 2020 |
| Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs S Heinzlmeir, D Kudlinzki, S Sreeramulu, S Klaeger, SL Gande, V Linhard, ... ACS chemical biology 11 (12), 3400-3411, 2016 | 57 | 2016 |
| Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins C Pechincha, S Groessl, R Kalis, M de Almeida, A Zanotti, M Wittmann, ... Science 378 (6615), eabn5637, 2022 | 51 | 2022 |
| Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A B Hoermann, T Kokot, D Helm, S Heinzlmeir, JE Chojnacki, T Schubert, ... Nature Communications 11 (1), 3583, 2020 | 49 | 2020 |
Bernhard KusterProfessor for Proteomics and BioanalyticsVerified email at tum.de
