| Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer KD Proffitt, B Madan, Z Ke, V Pendharkar, L Ding, MA Lee, RN Hannoush, ... Cancer research 73 (2), 502-507, 2013 | 407 | 2013 |
| Reconstitution of a Frizzled8· Wnt3a· LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6 E Bourhis, C Tam, Y Franke, JF Bazan, J Ernst, J Hwang, M Costa, ... Journal of Biological Chemistry 285 (12), 9172-9179, 2010 | 281 | 2010 |
| A caspase cascade regulating developmental axon degeneration DJ Simon, RM Weimer, T McLaughlin, D Kallop, K Stanger, J Yang, ... Journal of Neuroscience 32 (49), 17540-17553, 2012 | 245 | 2012 |
| Palmitoylation of TEAD transcription factors is required for their stability and function in Hippo pathway signaling CL Noland, S Gierke, PD Schnier, J Murray, WN Sandoval, M Sagolla, ... Structure 24 (1), 179-186, 2016 | 228 | 2016 |
| The chemical toolbox for monitoring protein fatty acylation and prenylation RN Hannoush, JL Sun Nature chemical biology 6 (7), 498-506, 2010 | 211 | 2010 |
| Inhibition of Wnt signaling by Dishevelled PDZ peptides Y Zhang, BA Appleton, C Wiesmann, T Lau, M Costa, RN Hannoush, ... Nature chemical biology 5 (4), 217-219, 2009 | 196 | 2009 |
| Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine X Gao, RN Hannoush Nature chemical biology 10 (1), 61-68, 2014 | 188 | 2014 |
| Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs JP Dijksterhuis, B Baljinnyam, K Stanger, HO Sercan, Y Ji, O Andres, ... Journal of Biological Chemistry 290 (11), 6789-6798, 2015 | 184 | 2015 |
| Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies Y Gong, E Bourhis, C Chiu, S Stawicki, VI DeAlmeida, BY Liu, ... PloS one 5 (9), e12682, 2010 | 169 | 2010 |
| Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6 E Bourhis, W Wang, C Tam, J Hwang, Y Zhang, D Spittler, OW Huang, ... Structure 19 (10), 1433-1442, 2011 | 165 | 2011 |
| Imaging the lipidome: ω-alkynyl fatty acids for detection and cellular visualization of lipid-modified proteins RN Hannoush, N Arenas-Ramirez ACS chemical biology 4 (7), 581-587, 2009 | 164 | 2009 |
| The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins K Suryamohan, SP Krishnankutty, J Guillory, M Jevit, MS Schröder, M Wu, ... Nature Genetics 52 (1), 106-117, 2020 | 160 | 2020 |
| Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling XD Huang, JC McGann, BY Liu, RN Hannoush, JR Lill, V Pham, ... Science 339 (6126), 1441-1445, 2013 | 134 | 2013 |
| Regulation of the oncoprotein Smoothened by small molecules HJ Sharpe, W Wang, RN Hannoush, FJ De Sauvage Nature chemical biology 11 (4), 246-255, 2015 | 132 | 2015 |
| Engineering and structural characterization of a linear polyubiquitin-specific antibody ML Matsumoto, KC Dong, C Yu, L Phu, X Gao, RN Hannoush, ... Journal of molecular biology 418 (3-4), 134-144, 2012 | 125 | 2012 |
| Fatty acylation of Wnt proteins AH Nile, RN Hannoush Nature chemical biology 12 (2), 60-69, 2016 | 115 | 2016 |
| Scalable total synthesis and biological evaluation of haouamine A and its atropisomer NZ Burns, IN Krylova, RN Hannoush, PS Baran Journal of the American Chemical Society 131 (26), 9172-9173, 2009 | 115 | 2009 |
| Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding AH Nile, S Mukund, K Stanger, W Wang, RN Hannoush Proceedings of the National Academy of Sciences 114 (16), 4147-4152, 2017 | 113 | 2017 |
| Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors BC Goess, RN Hannoush, LK Chan, T Kirchhausen, MD Shair Journal of the American Chemical Society 128 (16), 5391-5403, 2006 | 92 | 2006 |
| A decade of click chemistry in protein palmitoylation: impact on discovery and new biology X Gao, RN Hannoush Cell chemical biology 25 (3), 236-246, 2018 | 86 | 2018 |