| The current status of heterocyclic combinatorial libraries A Nefzi, JM Ostresh, RA Houghten Chemical reviews 97 (2), 449-472, 1997 | 764 | 1997 |
| Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity AD Schimmer, K Welsh, C Pinilla, Z Wang, M Krajewska, MJ Bonneau, ... Cancer cell 5 (1), 25-35, 2004 | 552 | 2004 |
| Pseudo-prolines as a solubilizing, structure-disrupting protection technique in peptide synthesis T Wöhr, F Wahl, A Nefzi, B Rohwedder, T Sato, X Sun, M Mutter Journal of the American Chemical Society 118 (39), 9218-9227, 1996 | 468 | 1996 |
| Mixture-based synthetic combinatorial libraries RA Houghten, C Pinilla, JR Appel, SE Blondelle, CT Dooley, J Eichler, ... Journal of medicinal chemistry 42 (19), 3743-3778, 1999 | 308 | 1999 |
| Pseudo-prolines (psi Pro) for accessing" inaccessible" peptides. M Mutter, A Nefzi, T Sato, X Sun, F Wahl, T Wöhr Peptide research 8 (3), 145-153, 1995 | 199 | 1995 |
| Integrating virtual screening and combinatorial chemistry for accelerated drug discovery F López-Vallejo, T Caulfield, K Martínez-Mayorga, M A Giulianotti, A Nefzi, ... Combinatorial Chemistry & High Throughput Screening 14 (6), 475-487, 2011 | 194 | 2011 |
| Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells BZ Carter, M Gronda, Z Wang, K Welsh, C Pinilla, M Andreeff, ... Blood 105 (10), 4043-4050, 2005 | 177 | 2005 |
| Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods RA Houghten, C Pinilla, MA Giulianotti, JR Appel, CT Dooley, A Nefzi, ... Journal of combinatorial chemistry 10 (1), 3-19, 2008 | 149 | 2008 |
| Solid-phase synthesis of trisubstituted bicyclic guanidines via cyclization of reduced N-acylated dipeptides JM Ostresh, CC Schoner, VT Hamashin, A Nefzi, JP Meyer, RA Houghten The Journal of organic chemistry 63 (24), 8622-8623, 1998 | 148 | 1998 |
| Synthesis of functionalized tetrasubstituted pyrazolyl heterocycles–a review S Dadiboyena, A Nefzi European journal of medicinal chemistry 46 (11), 5258-5275, 2011 | 145 | 2011 |
| Combinatorial chemistry: libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight … A Nefzi, JM Ostresh, J Yu, RA Houghten The Journal of organic chemistry 69 (11), 3603-3609, 2004 | 122 | 2004 |
| Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug-resistant Gram-positive pathogens identified from a mixture-based combinatorial library ME Hensler, G Bernstein, V Nizet, A Nefzi Bioorganic & medicinal chemistry letters 16 (19), 5073-5079, 2006 | 111 | 2006 |
| Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds A Nefzi, C Dooley, JM Ostresh, RA Houghten Bioorganic & medicinal chemistry letters 8 (17), 2273-2278, 1998 | 108 | 1998 |
| Solid phase synthesis of heterocyclic compounds from linear peptides: cyclic ureas and thioureas A Nefzi, JM Ostresh, JP Meyer, RA Houghten Tetrahedron letters 38 (6), 931-934, 1997 | 105 | 1997 |
| Combinatorial libraries as a tool for the discovery of novel, broad-spectrum antibacterial agents targeting the ESKAPE pathogens R Fleeman, TM LaVoi, RG Santos, A Morales, A Nefzi, GS Welmaker, ... Journal of medicinal chemistry 58 (8), 3340-3355, 2015 | 100 | 2015 |
| Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis AP Kater, F Dicker, M Mangiola, K Welsh, R Houghten, J Ostresh, A Nefzi, ... Blood 106 (5), 1742-1748, 2005 | 90 | 2005 |
| Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof A Nefzi, JM Ostresh, RA Houghten US Patent 6,441,172, 2002 | 85 | 2002 |
| Solid phase synthesis of 1, 3, 4, 7-Tetrasubstituted Perhydro-1, 4-diazepine-2, 5-diones A Nefzi, JM Ostresh, RA Houghten Tetrahedron letters 38 (28), 4943-4946, 1997 | 80 | 1997 |
| Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine CD Hayes, D Dey, JP Palavicini, H Wang, KA Patkar, D Minond, A Nefzi, ... BMC medicine 11, 1-22, 2013 | 69 | 2013 |
| Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library KJ Reilley, M Giulianotti, CT Dooley, A Nefzi, JP McLaughlin, ... The AAPS journal 12, 318-329, 2010 | 69 | 2010 |