| Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ... Nature genetics 49 (9), 1373-1384, 2017 | 959 | 2017 |
| IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior P Chakrabarty, A Li, C Ceballos-Diaz, JA Eddy, CC Funk, B Moore, ... Neuron 85 (3), 519-533, 2015 | 393 | 2015 |
| Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition P Chakrabarty, K Jansen-West, A Beccard, C Ceballos-Diaz, Y Levites, ... The FASEB Journal 24 (2), 548, 2010 | 382 | 2010 |
| Meta-analysis of the Alzheimer’s disease human brain transcriptome and functional dissection in mouse models YW Wan, R Al-Ouran, CG Mangleburg, TM Perumal, TV Lee, K Allison, ... Cell reports 32 (2), 2020 | 233 | 2020 |
| IFN-γ promotes complement expression and attenuates amyloid plaque deposition in amyloid β precursor protein transgenic mice P Chakrabarty, C Ceballos-Diaz, A Beccard, C Janus, D Dickson, ... The Journal of Immunology 184 (9), 5333-5343, 2010 | 212 | 2010 |
| Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain P Chakrabarty, A Rosario, P Cruz, Z Siemienski, C Ceballos-Diaz, ... PloS one 8 (6), e67680, 2013 | 210 | 2013 |
| Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo P Chakrabarty, A Herring, C Ceballos-Diaz, P Das, TE Golde Molecular neurodegeneration 6, 1-10, 2011 | 143 | 2011 |
| α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease ZA Sorrentino, BI Giasson, P Chakrabarty Acta neuropathologica 138, 1-21, 2019 | 140 | 2019 |
| Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease T Williams, DR Borchelt, P Chakrabarty Molecular neurodegeneration 15, 1-19, 2020 | 137 | 2020 |
| Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph L Magno, CB Lessard, M Martins, V Lang, P Cruz, Y Asi, M Katan, ... Alzheimer's research & therapy 11, 1-11, 2019 | 136 | 2019 |
| Microglia-specific targeting by novel capsid-modified AAV6 vectors AM Rosario, PE Cruz, C Ceballos-Diaz, MR Strickland, Z Siemienski, ... Molecular Therapy Methods & Clinical Development 3, 2016 | 135 | 2016 |
| Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies KH Strang, CL Croft, ZA Sorrentino, P Chakrabarty, TE Golde, BI Giasson Journal of biological chemistry 293 (7), 2408-2421, 2018 | 134 | 2018 |
| Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains BD Moore, P Chakrabarty, Y Levites, TL Kukar, AM Baine, T Moroni, ... Alzheimer's research & therapy 4, 1-15, 2012 | 132 | 2012 |
| Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases M Allen, X Wang, JD Burgess, J Watzlawik, DJ Serie, CS Younkin, ... Alzheimer's & dementia 14 (3), 352-366, 2018 | 128 | 2018 |
| Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition P Chakrabarty, L Tianbai, A Herring, C Ceballos-Diaz, P Das, TE Golde Molecular neurodegeneration 7, 1-12, 2012 | 126 | 2012 |
| Normal cognition in transgenic BRI2-Aβ mice J Kim, P Chakrabarty, A Hanna, A March, DW Dickson, DR Borchelt, ... Molecular neurodegeneration 8, 1-12, 2013 | 123 | 2013 |
| Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice M Zhang, J Li, P Chakrabarty, B Bu, I Vincent The American journal of pathology 165 (3), 843-853, 2004 | 122 | 2004 |
| Appoptosin-mediated caspase cleavage of tau contributes to progressive supranuclear palsy pathogenesis Y Zhao, IC Tseng, CJ Heyser, E Rockenstein, M Mante, A Adame, ... Neuron 87 (5), 963-975, 2015 | 105 | 2015 |
| Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice KHJ Park, JL Hallows, P Chakrabarty, P Davies, I Vincent Journal of Neuroscience 27 (11), 2969-2978, 2007 | 104 | 2007 |
| Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice T Zu, S Guo, O Bardhi, DA Ryskamp, J Li, S Khoramian Tusi, ... Proceedings of the National Academy of Sciences 117 (31), 18591-18599, 2020 | 94 | 2020 |
