| A network integration approach for drug-target interaction prediction and computational drug repositioning from heterogeneous information Y Luo, X Zhao, J Zhou, J Yang, Y Zhang, W Kuang, J Peng, L Chen, ... Nature communications 8 (1), 573, 2017 | 747 | 2017 |
| Apolipoprotein E4 causes age-and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice Y Andrews-Zwilling, N Bien-Ly, Q Xu, G Li, A Bernardo, SY Yoon, ... Journal of Neuroscience 30 (41), 13707-13717, 2010 | 382 | 2010 |
| A deep learning framework for modeling structural features of RNA-binding protein targets S Zhang, J Zhou, H Hu, H Gong, L Chen, C Cheng, J Zeng Nucleic acids research 44 (4), e32-e32, 2016 | 303 | 2016 |
| Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin Y Chen, S Li, C Brown, S Cheatham, RA Castro, MK Leabman, TJ Urban, ... Pharmacogenetics and genomics 19 (7), 497-504, 2009 | 292 | 2009 |
| Memory T cells: strategies for optimizing tumor immunotherapy Q Liu, Z Sun, L Chen Protein & cell 11 (8), 549-564, 2020 | 249 | 2020 |
| Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin L Chen, B Pawlikowski, A Schlessinger, SS More, D Stryke, SJ Johns, ... Pharmacogenetics and genomics 20 (11), 687-699, 2010 | 249 | 2010 |
| OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin L Chen, Y Shu, X Liang, EC Chen, SW Yee, AA Zur, S Li, L Xu, ... Proceedings of the National Academy of Sciences 111 (27), 9983-9988, 2014 | 243 | 2014 |
| Regulation of glucose and lipid metabolism in health and disease L Chen, XW Chen, X Huang, BL Song, Y Wang, Y Wang Science China life sciences 62, 1420-1458, 2019 | 220 | 2019 |
| The SLC transporter in nutrient and metabolic sensing, regulation, and drug development Y Zhang, Y Zhang, K Sun, Z Meng, L Chen Journal of molecular cell biology 11 (1), 1-13, 2019 | 192 | 2019 |
| Structural model for γ-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same site L Chen, KA Durkin, JE Casida Proceedings of the National Academy of Sciences 103 (13), 5185-5190, 2006 | 184 | 2006 |
| A functional mammalian target of rapamycin complex 1 signaling is indispensable for c‐Myc‐driven hepatocarcinogenesis P Liu, M Ge, J Hu, X Li, L Che, K Sun, L Cheng, Y Huang, MG Pilo, ... Hepatology 66 (1), 167-181, 2017 | 170 | 2017 |
| Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans LI Che, W Chi, Y Qiao, J Zhang, X Song, YE Liu, L Li, J Jia, MG Pilo, ... Gut 69 (1), 177-186, 2020 | 167 | 2020 |
| A data-driven drug repositioning framework discovered a potential therapeutic agent targeting COVID-19 Y Ge, T Tian, S Huang, F Wan, J Li, S Li, H Yang, L Hong, N Wu, E Yuan, ... BioRxiv, 2020.03. 11.986836, 2020 | 165 | 2020 |
| Solute carrier transporters: the metabolic gatekeepers of immune cells W Song, D Li, L Tao, Q Luo, L Chen Acta Pharmaceutica Sinica B 10 (1), 61-78, 2020 | 164 | 2020 |
| Slc6a8-mediated creatine uptake and accumulation reprogram macrophage polarization via regulating cytokine responses L Ji, X Zhao, B Zhang, L Kang, W Song, B Zhao, W Xie, L Chen, X Hu Immunity 51 (2), 272-284. e7, 2019 | 156 | 2019 |
| The solute carrier transporters and the brain: Physiological and pharmacological implications C Hu, L Tao, X Cao, L Chen Asian journal of pharmaceutical sciences 15 (2), 131-144, 2020 | 150 | 2020 |
| The physiological role of drug transporters Y Liang, S Li, L Chen Protein & cell 6 (5), 334-350, 2015 | 135 | 2015 |
| Hematopoietic progenitor kinase1 (HPK1) mediates T cell dysfunction and is a druggable target for T cell-based immunotherapies J Si, X Shi, S Sun, B Zou, Y Li, D An, X Lin, Y Gao, F Long, B Pang, X Liu, ... Cancer cell 38 (4), 551-566. e11, 2020 | 131 | 2020 |
| Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin EC Chen, X Liang, SW Yee, EG Geier, SL Stocker, L Chen, KM Giacomini Molecular pharmacology 88 (1), 75-83, 2015 | 117 | 2015 |
| Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function L Chen, M Takizawa, E Chen, A Schlessinger, J Segenthelar, JH Choi, ... Journal of Pharmacology and Experimental Therapeutics 335 (1), 42-50, 2010 | 112 | 2010 |
Kathleen M. GiacominiProfessor, UCSFVerified email at ucsf.edu