Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. TM Consortium Nature 562 (7727), 367, 2018 | 2251* | 2018 |
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse Nature 583 (7817), 590-595, 2020 | 888 | 2020 |
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain J Marschallinger, T Iram, M Zardeneta, SE Lee, B Lehallier, MS Haney, ... Nature neuroscience 23 (2), 194-208, 2020 | 838 | 2020 |
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease D Gate, N Saligrama, O Leventhal, AC Yang, MS Unger, J Middeldorp, ... Nature 577 (7790), 399-404, 2020 | 701 | 2020 |
Undulating changes in human plasma proteome profiles across the lifespan B Lehallier, D Gate, N Schaum, T Nanasi, SE Lee, H Yousef, ... Nature medicine 25 (12), 1843-1850, 2019 | 627 | 2019 |
Ageing hallmarks exhibit organ-specific temporal signatures N Schaum, B Lehallier, O Hahn, R Pálovics, S Hosseinzadeh, SE Lee, ... Nature 583 (7817), 596-602, 2020 | 453 | 2020 |
Physiological blood–brain transport is impaired with age by a shift in transcytosis AC Yang, MY Stevens, MB Chen, DP Lee, D Stähli, D Gate, K Contrepois, ... Nature 583 (7816), 425-430, 2020 | 359 | 2020 |
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1 H Yousef, CJ Czupalla, D Lee, MB Chen, AN Burke, KA Zera, J Zandstra, ... Nature medicine 25 (6), 988-1000, 2019 | 342 | 2019 |
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging N Sayed, Y Huang, K Nguyen, Z Krejciova-Rajaniemi, AP Grawe, T Gao, ... Nature aging 1 (7), 598-615, 2021 | 339 | 2021 |
Exercise plasma boosts memory and dampens brain inflammation via clusterin Z De Miguel, N Khoury, MJ Betley, B Lehallier, D Willoughby, N Olsson, ... Nature 600 (7889), 494-499, 2021 | 261 | 2021 |
Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy MS Ghaemi, DB DiGiulio, K Contrepois, B Callahan, TTM Ngo, ... Bioinformatics 35 (1), 95-103, 2019 | 170 | 2019 |
Brain endothelial cells are exquisite sensors of age-related circulatory cues MB Chen, AC Yang, H Yousef, D Lee, W Chen, N Schaum, B Lehallier, ... Cell reports 30 (13), 4418-4432. e4, 2020 | 168 | 2020 |
Preclinical assessment of young blood plasma for Alzheimer disease J Middeldorp, B Lehallier, SA Villeda, SSM Miedema, E Evans, E Czirr, ... JAMA neurology 73 (11), 1325-1333, 2016 | 160 | 2016 |
Organ aging signatures in the plasma proteome track health and disease HSH Oh, J Rutledge, D Nachun, R Pálovics, O Abiose, P Moran-Losada, ... Nature 624 (7990), 164-172, 2023 | 149 | 2023 |
Activation of the STING-dependent type I interferon response reduces microglial reactivity and neuroinflammation V Mathur, R Burai, RT Vest, LN Bonanno, B Lehallier, ME Zardeneta, ... Neuron 96 (6), 1290-1302. e6, 2017 | 145 | 2017 |
Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17 T Iram, F Kern, A Kaur, S Myneni, AR Morningstar, H Shin, MA Garcia, ... Nature 605 (7910), 509-515, 2022 | 144 | 2022 |
Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age AA Johnson, MN Shokhirev, T Wyss-Coray, B Lehallier Ageing research reviews 60, 101070, 2020 | 121 | 2020 |
A proteomic clock of human pregnancy N Aghaeepour, B Lehallier, Q Baca, EA Ganio, RJ Wong, MS Ghaemi, ... American journal of obstetrics and gynecology 218 (3), 347. e1-347. e14, 2018 | 110 | 2018 |
Predicting early symptomatic osteoarthritis in the human knee using machine learning classification of magnetic resonance images from the osteoarthritis initiative BG Ashinsky, M Bouhrara, CE Coletta, B Lehallier, KL Urish, PC Lin, ... Journal of Orthopaedic Research 35 (10), 2243-2250, 2017 | 107 | 2017 |
Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging B Lehallier, MN Shokhirev, T Wyss‐Coray, AA Johnson Aging cell 19 (11), e13256, 2020 | 85 | 2020 |