| Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing S Liu, Q Cheng, T Wei, X Yu, LT Johnson, L Farbiak, DJ Siegwart Nature materials 20 (5), 701-710, 2021 | 399 | 2021 |
| Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery X Wang, S Liu, Y Sun, X Yu, SM Lee, Q Cheng, T Wei, J Gong, ... Nature protocols 18 (1), 265-291, 2023 | 199 | 2023 |
| Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy D Zhang, G Wang, X Yu, T Wei, L Farbiak, LT Johnson, AM Taylor, J Xu, ... Nature nanotechnology 17 (7), 777-787, 2022 | 139 | 2022 |
| Zwitterionic phospholipidation of cationic polymers facilitates systemic mRNA delivery to spleen and lymph nodes S Liu, X Wang, X Yu, Q Cheng, LT Johnson, S Chatterjee, D Zhang, ... Journal of the American Chemical Society 143 (50), 21321-21330, 2021 | 113 | 2021 |
| A systematic study of unsaturation in lipid nanoparticles leads to improved mRNA transfection in vivo SM Lee, Q Cheng, X Yu, S Liu, LT Johnson, DJ Siegwart Angewandte Chemie 133 (11), 5912-5917, 2021 | 97 | 2021 |
| A biomimetic total synthesis of (+)-ainsliadimer A C Li, X Yu, X Lei Organic letters 12 (19), 4284-4287, 2010 | 89 | 2010 |
| Stereoselective 6π-electron electrocyclic ring closures of 2-halo-amidotrienes via a remote 1, 6-asymmetric induction R Hayashi, MC Walton, RP Hsung, JH Schwab, X Yu Organic letters 12 (24), 5768-5771, 2010 | 46 | 2010 |
| Lipid‐Modified Aminoglycosides for mRNA Delivery to the Liver X Yu, S Liu, Q Cheng, T Wei, S Lee, D Zhang, DJ Siegwart Advanced Healthcare Materials, 1901487, 2020 | 39 | 2020 |
| TfOH-mediated [2 + 2 + 2] cycloadditions of ynamides with two discrete nitriles: synthesis of 4-aminopyrimidine derivatives YT Ping Chen, Cai-xia Song, Wan-shu Wang, Xue-liang Yu RSC Adv. 6 (RSC), 80055-80058, 2016 | 39 | 2016 |
| In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration Y Jia, L Li, YH Lin, P Gopal, S Shen, K Zhou, X Yu, T Sharma, Y Zhang, ... Cell Stem Cell 29 (3), 372-385. e8, 2022 | 33 | 2022 |
| Hydrophobic domain structure of linear-dendritic poly (ethylene glycol) lipids affects RNA delivery of lipid nanoparticles K Zhou, LT Johnson, H Xiong, S Barrios, JT Minnig, Y Yan, B Abram, X Yu, ... Molecular Pharmaceutics 17 (5), 1575-1585, 2020 | 20 | 2020 |
| ASSEMBLY OF THE SOUTHERN MACROCYCLIC HALF OF (+)-SPIRASTRELLOLIDE A THROUGH CYCLIC ACETAL TETHERED RING-CLOSING METATHESIS AND 1, 3-ANTI-MUKAIYAMA-ALDOL (Dedicated to Professor … RP Tang, Y, Yang, JH, Liu, J, Wang, CC, Lv, MC, Wu, YB, Yu, XL, Ko, CH, Hsung Heterocycles: an international journal for reviews and communications in …, 2012 | 10* | 2012 |
| Hydrophobic optimization of functional poly (TPAE-co-suberoyl chloride) for extrahepatic mRNA delivery following Intravenous Administration X Yu, S Liu, Q Cheng, SM Lee, T Wei, D Zhang, L Farbiak, LT Johnson, ... Pharmaceutics 13 (11), 1914, 2021 | 8 | 2021 |
| A convergent approach toward fidaxomicin: Syntheses of the fully glycosylated northern and southern fragments R Hollibaugh, X Yu, JK De Brabander Tetrahedron 76 (49), 131673, 2020 | 6 | 2020 |
| Functional Rescue of CFTR by Aerosolized Delivery of Optimized CFTR mRNA Using ReCode LNPs in Primary Human Bronchial Epithelial Cells Derived from Patients with Cystic Fibrosis D Ishimaru, D Boudko, EA Meleshkevitch, MS Sidhu, JR Poniatowski, ... D109. AIRWAY OF INTEREST: EPITHELIAL AND SMOOTH MUSCLE FUNCTION IN HEALTH …, 2022 | 3 | 2022 |
| Rescue of ciliary function in cell-based primary ciliary dyskinesia models using nebulized, lipid nanoparticle (LNP)-formulated mRNA R Bhattacharjee, M Hennig, D Ishimaru, DR Liston, JK Eby, CC Corona, ... A62. CYSTIC FIBROSIS AND NON-CF BRONCHIECTASIS: MECHANISTIC INSIGHTS, A1998 …, 2022 | 3 | 2022 |
| An mRNA-Based Therapy to Treat Primary Ciliary Dyskinesia: Aerosol Delivery, Biodistribution and Tolerability D Liston, M Hennig, D Ishimaru, JK Eby, S Ahmed, X Yu, A Alfaifi, ... A62 Cystic fibrosis and NON-CF bronchiectasis: mechanistic insights …, 2022 | 3 | 2022 |
| 583: Variant-agnostic CFTR rescue using aerosolized delivery of CFTR mRNA using the SORT-LNP in primary human bronchial epithelial cells derived from patients with cystic fibrosis M Torres, D Boudko, E Meleshkevitch, M Coquelin, X Yu, J Eby, ... Journal of Cystic Fibrosis 20, S278, 2021 | 2 | 2021 |
| WS09. 3 Rescue of CFTR function in primary bronchial epithelial cells from patients with cystic fibrosis using lipid nanoparticle delivery of RNAbased therapies M Torres, D Boudko, E Meleshkevitch, M Coquelin, X Yu, J Eby, ... Journal of Cystic Fibrosis 20, S17-S18, 2021 | 2 | 2021 |
| Total Synthesis of Mangrolide A X Yu | 1 | 2018 |
Daniel SiegwartProfessor, University of Texas Southwestern Medical CenterVerified email at utsouthwestern.edu