| Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways J Lee, EW Su, C Zhu, S Hainline, J Phuah, JA Moroco, TE Smithgall, ... Molecular and cellular biology, 2011 | 318 | 2011 |
| Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice R Mourtada, HD Herce, DJ Yin, JA Moroco, TE Wales, JR Engen, ... Nature biotechnology 37 (10), 1186-1197, 2019 | 248 | 2019 |
| Differential sensitivity of Src-family kinases to activation by SH3 domain displacement JA Moroco, JK Craigo, RE Iacob, TE Wales, JR Engen, TE Smithgall PloS one 9 (8), e105629, 2014 | 51 | 2014 |
| Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism JJ Alvarado, L Betts, JA Moroco, TE Smithgall, JI Yeh Journal of Biological Chemistry 285 (46), 35455-35461, 2010 | 42 | 2010 |
| Discovery of a first-in-class inhibitor of the PRMT5–substrate adaptor interaction DC McKinney, BJ McMillan, MJ Ranaghan, JA Moroco, M Brousseau, ... Journal of medicinal chemistry 64 (15), 11148-11168, 2021 | 40 | 2021 |
| Allosteric control of Ubp6 and the proteasome via a bidirectional switch KYS Hung, S Klumpe, MR Eisele, S Elsasser, G Tian, S Sun, JA Moroco, ... Nature communications 13 (1), 838, 2022 | 34 | 2022 |
| Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state PG Miller, M Sathappa, JA Moroco, W Jiang, Y Qian, S Iqbal, Q Guo, ... Nature Communications 13 (1), 3778, 2022 | 31 | 2022 |
| Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding JR Kardon, JA Moroco, JR Engen, TA Baker Elife 9, e54387, 2020 | 31 | 2020 |
| The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation K Shen, JA Moroco, RK Patel, H Shi, JR Engen, HR Dorman, TE Smithgall Science signaling 11 (553), eaat5916, 2018 | 30 | 2018 |
| HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck T Pene-Dumitrescu, ST Shu, TE Wales, JJ Alvarado, H Shi, P Narute, ... BMC Chemical Biology 12, 1-12, 2012 | 27 | 2012 |
| Multimodal small-molecule screening for human prion protein binders AG Reidenbach, MF Mesleh, D Casalena, SM Vallabh, JL Dahlin, ... Journal of Biological Chemistry 295 (39), 13516-13531, 2020 | 26 | 2020 |
| Replication in bioanalytical studies with HDX MS: aim as high as possible JA Moroco, JR Engen Bioanalysis 7 (9), 1065-1067, 2015 | 22 | 2015 |
| Remodeling of HIV-1 Nef structure by Src-family kinase binding JA Moroco, JJ Alvarado, RP Staudt, H Shi, TE Wales, TE Smithgall, ... Journal of molecular biology 430 (3), 310-321, 2018 | 21 | 2018 |
| A Discovery Strategy for Selective Inhibitors of c‐Src in Complex with the Focal Adhesion Kinase SH3/SH2‐binding Region JA Moroco, MP Baumgartner, HL Rust, HG Choi, W Hur, NS Gray, ... Chemical biology & drug design 86 (2), 144-155, 2015 | 16 | 2015 |
| Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35 TC Atack, DD Raymond, CA Blomquist, CF Pasaje, PR McCarren, ... ACS Medicinal Chemistry Letters 11 (11), 2131-2138, 2020 | 10 | 2020 |
| Design of stapled antimicrobial peptides that overcome antibiotic resistance and in vivo toxicity R Mourtada, HD Herce, DJ Yin, JA Moroco, TE Wales, JR Engen, ... Nature biotechnology 37 (10), 1186, 2019 | 10 | 2019 |
| ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr S Du, JJ Alvarado, TE Wales, JA Moroco, JR Engen, TE Smithgall Structure 30 (11), 1508-1517. e3, 2022 | 8 | 2022 |
| Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency MS Prew, CM Camara, T Botzanowski, JA Moroco, NB Bloch, HR Levy, ... Nature Communications 13 (1), 3669, 2022 | 8 | 2022 |
| Abstract B190: Allosteric modulation of Src family kinases via SH3 domain displacement HL Rust, JA Moroco, JJ Alvarado, JJ Engen, TE Smithgall Molecular Cancer Therapeutics 14 (12_Supplement_2), B190-B190, 2015 | 2 | 2015 |
| High-Throughput Determination of Exchange Rates of Unmodified and PTM-Containing Peptides Using HX-MS JA Moroco, ASV Jacome, PMJ Beltran, A Reiter, C Mundorff, M Guttman, ... Molecular & Cellular Proteomics 24 (2), 2025 | | 2025 |
Thomas E. SmithgallUniversity of PittsburghVerified email at pitt.edu