Autoantibodies against type I IFNs in patients with life-threatening COVID-19 P Bastard, LB Rosen, Q Zhang, E Michailidis, HH Hoffmann, Y Zhang, ... Science 370 (6515), eabd4585, 2020 | 2674 | 2020 |
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Q Zhang, P Bastard, Z Liu, J Le Pen, M Moncada-Velez, J Chen, M Ogishi, ... Science 370 (6515), eabd4570, 2020 | 2297 | 2020 |
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ... Science immunology 6 (62), eabl4340, 2021 | 513 | 2021 |
X-linked recessive TLR7 deficiency in~ 1% of men under 60 years old with life-threatening COVID-19 T Asano, B Boisson, F Onodi, D Matuozzo, M Moncada-Velez, ... Science immunology 6 (62), eabl4348, 2021 | 372 | 2021 |
Human genetic and immunological determinants of critical COVID-19 pneumonia Q Zhang, P Bastard, A Cobat, JL Casanova Nature 603 (7902), 587-598, 2022 | 272 | 2022 |
A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection JL Casanova, HC Su, L Abel, A Aiuti, S Almuhsen, AA Arias, P Bastard, ... Cell 181 (6), 1194-1199, 2020 | 267 | 2020 |
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1 P Bastard, E Orlova, L Sozaeva, R Lévy, A James, MM Schmitt, S Ochoa, ... Journal of Experimental Medicine 218 (7), 2021 | 266 | 2021 |
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19 MGP van der Wijst, SE Vazquez, GC Hartoularos, P Bastard, T Grant, ... Science translational medicine 13 (612), eabh2624, 2021 | 195 | 2021 |
Severe influenza pneumonitis in children with inherited TLR3 deficiency HK Lim, SXL Huang, J Chen, G Kerner, O Gilliaux, P Bastard, K Dobbs, ... Journal of Experimental Medicine 216 (9), 2038-2056, 2019 | 185 | 2019 |
Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine P Bastard, E Michailidis, HH Hoffmann, M Chbihi, T Le Voyer, J Rosain, ... Journal of Experimental Medicine 218 (4), e20202486, 2021 | 173 | 2021 |
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies J Manry, P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, ... Proceedings of the National Academy of Sciences 119 (21), 2022 | 155 | 2022 |
Life-threatening COVID-19: defective interferons unleash excessive inflammation Q Zhang, P Bastard, A Bolze, E Jouanguy, SY Zhang, A Cobat, ... Med 1 (1), 14-20, 2020 | 146 | 2020 |
Polyclonal expansion of TCR Vβ 21.3+ CD4+ and CD8+ T cells is a hallmark of multisystem inflammatory syndrome in children M Moreews, K Le Gouge, S Khaldi-Plassart, R Pescarmona, AL Mathieu, ... Science immunology 6 (59), eabh1516, 2021 | 143 | 2021 |
Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs J Lopez, M Mommert, W Mouton, A Pizzorno, K Brengel-Pesce, M Mezidi, ... Journal of Experimental Medicine 218 (10), e20211211, 2021 | 137 | 2021 |
Neutralizing autoantibodies to type I IFNs in> 10% of patients with severe COVID-19 pneumonia hospitalized in Madrid, Spain J Troya, P Bastard, L Planas-Serra, P Ryan, M Ruiz, M de Carranza, ... Journal of clinical immunology 41, 914-922, 2021 | 130 | 2021 |
Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients R Koning, P Bastard, JL Casanova, MC Brouwer, D van de Beek Intensive care medicine 47, 704-706, 2021 | 121 | 2021 |
COVID Human Genetic Effort, Cobat A, Casanova JL Q Zhang, P Bastard Human genetic and immunological determinants of critical COVID-19 pneumonia …, 2022 | 109 | 2022 |
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells R Planès, M Pinilla, K Santoni, A Hessel, C Passemar, K Lay, P Paillette, ... Molecular cell 82 (13), 2385-2400. e9, 2022 | 108 | 2022 |
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort R Carapito, R Li, J Helms, C Carapito, S Gujja, V Rolli, R Guimaraes, ... Science translational medicine 14 (628), eabj7521, 2022 | 106 | 2022 |
Autoantibodies and SARS-CoV2 infection: The spectrum from association to clinical implication: Report of the 15th Dresden Symposium on Autoantibodies J Damoiseaux, A Dotan, MJ Fritzler, DP Bogdanos, PL Meroni, ... Autoimmunity reviews 21 (3), 103012, 2022 | 105 | 2022 |