Atypical ubiquitylation—the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages Y Kulathu, D Komander Nature reviews Molecular cell biology 13 (8), 508-523, 2012 | 789 | 2012 |
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis TET Mevissen, MK Hospenthal, PP Geurink, PR Elliott, M Akutsu, ... Cell 154 (1), 169-184, 2013 | 619 | 2013 |
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin K Keusekotten, PR Elliott, L Glockner, BK Fiil, RB Damgaard, Y Kulathu, ... Cell 153 (6), 1312-1326, 2013 | 491 | 2013 |
MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes SAA Rehman, YA Kristariyanto, SY Choi, PJ Nkosi, S Weidlich, K Labib, ... Molecular cell 63 (1), 146-155, 2016 | 404 | 2016 |
On terminal alkynes that can react with active-site cysteine nucleophiles in proteases R Ekkebus, SI van Kasteren, Y Kulathu, A Scholten, I Berlin, PP Geurink, ... Journal of the American Chemical Society 135 (8), 2867-2870, 2013 | 364 | 2013 |
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain Y Kulathu, M Akutsu, A Bremm, K Hofmann, D Komander Nature structural & molecular biology 16 (12), 1328-1330, 2009 | 222 | 2009 |
Discovery and characterization of ZUFSP/ZUP1, a distinct deubiquitinase class important for genome stability D Kwasna, SAA Rehman, J Natarajan, S Matthews, R Madden, ... Molecular Cell 70 (1), 150-164. e6, 2018 | 211 | 2018 |
K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin YA Kristariyanto, SAA Rehman, DG Campbell, NA Morrice, C Johnson, ... Molecular cell 58 (1), 83-94, 2015 | 187 | 2015 |
Deubiquitinases: From mechanisms to their inhibition by small molecules SM Lange, LA Armstrong, Y Kulathu Molecular cell 82 (1), 15-29, 2022 | 174 | 2022 |
Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne TET Mevissen, Y Kulathu, MPC Mulder, PP Geurink, SL Maslen, M Gersch, ... Nature 538 (7625), 402-405, 2016 | 159 | 2016 |
Regulation of A20 and other OTU deubiquitinases by reversible oxidation Y Kulathu, FJ Garcia, TET Mevissen, M Busch, N Arnaudo, KS Carroll, ... Nature communications 4 (1), 1569, 2013 | 134 | 2013 |
Mechanisms of regulation and diversification of deubiquitylating enzyme function P Leznicki, Y Kulathu Journal of cell science 130 (12), 1997-2006, 2017 | 112 | 2017 |
The kinase Syk as an adaptor controlling sustained calcium signalling and B‐cell development Y Kulathu, E Hobeika, G Turchinovich, M Reth The EMBO journal 27 (9), 1333-1344, 2008 | 112 | 2008 |
Deregulated Syk inhibits differentiation and induces growth factor–independent proliferation of pre–B cells T Wossning, S Herzog, F Köhler, S Meixlsperger, Y Kulathu, G Mittler, ... The Journal of experimental medicine 203 (13), 2829-2840, 2006 | 106 | 2006 |
Autoinhibition and adapter function of Syk Y Kulathu, G Grothe, M Reth Immunological reviews 232 (1), 286-299, 2009 | 105 | 2009 |
Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations YA Kristariyanto, SY Choi, SAA Rehman, MS Ritorto, DG Campbell, ... Biochemical Journal 467 (Pt 2), 345, 2015 | 93 | 2015 |
A leucine zipper in the N terminus confers membrane association to SLP-65 F Köhler, B Storch, Y Kulathu, S Herzog, S Kuppig, M Reth, H Jumaa Nature immunology 6 (2), 204-210, 2005 | 84 | 2005 |
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies LA Armstrong, SM Lange, V Dee Cesare, SP Matthews, RS Nirujogi, ... PloS one 16 (7), e0253364, 2021 | 76 | 2021 |
Synthesis of isomeric phosphoubiquitin chains reveals that phosphorylation controls deubiquitinase activity and specificity N Huguenin-Dezot, V De Cesare, J Peltier, A Knebel, YA Kristaryianto, ... Cell reports 16 (4), 1180-1193, 2016 | 72 | 2016 |
A single MIU motif of MINDY‐1 recognizes K48‐linked polyubiquitin chains YA Kristariyanto, SA Abdul Rehman, S Weidlich, A Knebel, Y Kulathu EMBO reports 18 (3), 392-402, 2017 | 69 | 2017 |