| Advances in mammalian cell line development technologies for recombinant protein production T Lai, Y Yang, SK Ng Pharmaceuticals 6 (5), 579-603, 2013 | 429 | 2013 |
| A study of monoclonal antibody‐producing CHO cell lines: What makes a stable high producer? J Chusainow, YS Yang, JHM Yeo, PC Toh, P Asvadi, NSC Wong, ... Biotechnology and bioengineering 102 (4), 1182-1196, 2009 | 410 | 2009 |
| Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs P Zhang, S Woen, T Wang, B Liau, S Zhao, C Chen, Y Yang, Z Song, ... Drug Discovery Today 21 (5), 740-765, 2016 | 244 | 2016 |
| IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines SCL Ho, M Bardor, H Feng, YW Tong, Z Song, MGS Yap, Y Yang Journal of biotechnology 157 (1), 130-139, 2012 | 195 | 2012 |
| Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells J Chng, T Wang, R Nian, A Lau, KM Hoi, SCL Ho, P Gagnon, X Bi, Y Yang MAbs 7 (2), 403-412, 2015 | 172 | 2015 |
| DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines Y Yang, J Chusainow, MGS Yap Journal of biotechnology 147 (3-4), 180-185, 2010 | 170 | 2010 |
| Optimization of heavy chain and light chain signal peptides for high level expression of therapeutic antibodies in CHO cells R Haryadi, S Ho, YJ Kok, HX Pu, L Zheng, NA Pereira, B Li, X Bi, LT Goh, ... PloS one 10 (2), e0116878, 2015 | 142 | 2015 |
| Mammalian systems biotechnology reveals global cellular adaptations in a recombinant CHO cell line FNK Yusufi, M Lakshmanan, YS Ho, BLW Loo, P Ariyaratne, Y Yang, ... Cell systems 4 (5), 530-542. e6, 2017 | 105 | 2017 |
| Control of IgG LC: HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability SCL Ho, EYC Koh, M van Beers, M Mueller, C Wan, G Teo, Z Song, ... Journal of biotechnology 165 (3-4), 157-166, 2013 | 102 | 2013 |
| Nonspecific interactions of chromatin with immunoglobulin G and protein A, and their impact on purification performance P Gagnon, R Nian, J Lee, L Tan, SMA Latiff, CL Lim, C Chuah, X Bi, ... Journal of Chromatography A 1340, 68-78, 2014 | 80 | 2014 |
| Principles and applications of steric exclusion chromatography J Lee, HT Gan, SMA Latiff, C Chuah, WY Lee, YS Yang, B Loo, SK Ng, ... Journal of Chromatography A 1270, 162-170, 2012 | 78 | 2012 |
| Inactivation of GDP-fucose transporter gene (Slc35c1) in CHO cells by ZFNs, TALENs and CRISPR-Cas9 for production of fucose-free antibodies. KF Chan, W Shahreel, C Wan, G Teo, N Hayati, SJ Tay, WH Tong, Y Yang, ... Biotechnology Journal 11 (3), 399-414, 2016 | 77 | 2016 |
| Comparison of internal ribosome entry site (IRES) and Furin-2A (F2A) for monoclonal antibody expression level and quality in CHO cells SCL Ho, M Bardor, B Li, JJ Lee, Z Song, YW Tong, LT Goh, Y Yang PloS one 8 (5), e63247, 2013 | 77 | 2013 |
| Evaluating post-transcriptional regulatory elements for enhancing transient gene expression levels in CHO K1 and HEK293 cells SCL Ho, MGS Yap, Y Yang Protein expression and purification 69 (1), 9-15, 2010 | 74 | 2010 |
| Impact of using different promoters and matrix attachment regions on recombinant protein expression level and stability in stably transfected CHO cells SCL Ho, fnm Mariati, JHM Yeo, SG Fang, Y Yang Molecular biotechnology 57, 138-144, 2015 | 73 | 2015 |
| An internal ribosome entry site (IRES) mutant library for tuning expression level of multiple genes in mammalian cells EYC Koh, SCL Ho, Mariati, Z Song, X Bi, M Bardor, Y Yang PLoS One 8 (12), e82100, 2013 | 70 | 2013 |
| IL-10 enhances human natural killer cell effector functions via metabolic reprogramming regulated by mTORC1 signaling Z Wang, D Guan, J Huo, SK Biswas, Y Huang, Y Yang, S Xu, KP Lam Frontiers in immunology 12, 619195, 2021 | 65 | 2021 |
| Generation of monoclonal antibody-producing mammalian cell lines SCL Ho, YW Tong, Y Yang Pharmaceutical bioprocessing 1 (1), 71-87, 2013 | 61 | 2013 |
| Overexpression of microRNAs enhances recombinant protein production in Chinese hamster ovary cells WP Loh, B Loo, L Zhou, P Zhang, DY Lee, Y Yang, KP Lam Biotechnology journal 9 (9), 1140-1151, 2014 | 60 | 2014 |
| Advance chromatin extraction improves capture performance of protein A affinity chromatography R Nian, W Zhang, L Tan, J Lee, X Bi, Y Yang, HT Gan, P Gagnon Journal of Chromatography A 1431, 1-7, 2016 | 58 | 2016 |
