| mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs RJO Dowling, I Topisirovic, T Alain, M Bidinosti, BD Fonseca, ... Science 328 (5982), 1172-1176, 2010 | 854 | 2010 |
| Dissecting the role of mTOR: lessons from mTOR inhibitors RJO Dowling, I Topisirovic, BD Fonseca, N Sonenberg Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (3), 433-439, 2010 | 589 | 2010 |
| Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling AD Balgi, BD Fonseca, E Donohue, TCF Tsang, P Lajoie, CG Proud, ... PloS one 4 (9), e7124, 2009 | 389 | 2009 |
| PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex BD Fonseca, EM Smith, VHY Lee, C MacKintosh, CG Proud Journal of Biological Chemistry 282 (34), 24514-24524, 2007 | 304 | 2007 |
| La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1) BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ... Journal of Biological Chemistry 290 (26), 15996-16020, 2015 | 299 | 2015 |
| Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling X Wang, BD Fonseca, H Tang, R Liu, A Elia, MJ Clemens, UA Bommer, ... Journal of Biological Chemistry 283 (45), 30482-30492, 2008 | 238 | 2008 |
| Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1 J Averous, BD Fonseca, CG Proud Oncogene 27 (8), 1106-1113, 2008 | 237 | 2008 |
| A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ... Molecular and cellular biology, 2012 | 229 | 2012 |
| La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs RM Lahr, BD Fonseca, GE Ciotti, HA Al-Ashtal, JJ Jia, MR Niklaus, ... Elife 6, e24146, 2017 | 214 | 2017 |
| eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ... Cancer research 72 (24), 6468-6476, 2012 | 198 | 2012 |
| Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling BD Fonseca, GH Diering, MA Bidinosti, K Dalal, T Alain, AD Balgi, ... Journal of Biological Chemistry 287 (21), 17530-17545, 2012 | 173 | 2012 |
| Regulation of mTORC1 signaling by pH AD Balgi, GH Diering, E Donohue, KKY Lam, BD Fonseca, C Zimmerman, ... PloS one 6 (6), e21549, 2011 | 137 | 2011 |
| The ever-evolving role of mTOR in translation BD Fonseca, EM Smith, N Yelle, T Alain, M Bushell, A Pause Seminars in cell & developmental biology 36, 102-112, 2014 | 133 | 2014 |
| S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3 F Wang, T Alain, KJ Szretter, K Stephenson, JG Pol, MJ Atherton, ... Nature immunology 17 (5), 514-522, 2016 | 92 | 2016 |
| Calpain activity is generally elevated during transformation but has oncogene-specific biological functions NO Carragher, BD Fonseca, MC Frame Neoplasia 6 (1), 53-73, 2004 | 92 | 2004 |
| mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1 JJ Jia, RM Lahr, MT Solgaard, BJ Moraes, R Pointet, AD Yang, G Celucci, ... Nucleic acids research 49 (6), 3461-3489, 2021 | 91 | 2021 |
| LARP1 on TOP of ribosome production BD Fonseca, RM Lahr, CK Damgaard, T Alain, AJ Berman Wiley Interdisciplinary Reviews: RNA 9 (5), e1480, 2018 | 82 | 2018 |
| Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3 Y Tsukumo, T Alain, BD Fonseca, R Nadon, N Sonenberg Nature communications 7 (1), 11776, 2016 | 63 | 2016 |
| Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated … BD Fonseca, T Alain, LK Finestone, BPH Huang, M Rolfe, T Jiang, Z Yao, ... Journal of Biological Chemistry 286 (31), 27111-27122, 2011 | 52 | 2011 |
| Analysis of the regulatory motifs in eukaryotic initiation factor 4E‐binding protein 1 VHY Lee, T Healy, BD Fonseca, A Hayashi, CG Proud The FEBS journal 275 (9), 2185-2199, 2008 | 51 | 2008 |
Tommy AlainChildren's Hospital of Eastern Ontario Research Institute and University of OttawaVerified email at arc.cheo.ca