A 45-amino-acid scaffold mined from the PDB for high-affinity ligand engineering MA Kruziki, S Bhatnagar, DR Woldring, VT Duong, BJ Hackel Chemistry & biology 22 (7), 946-956, 2015 | 70 | 2015 |
High-throughput ligand discovery reveals a sitewise gradient of diversity in broadly evolved hydrophilic fibronectin domains DR Woldring, PV Holec, H Zhou, BJ Hackel PLoS One 10 (9), e0138956, 2015 | 55 | 2015 |
A gradient of sitewise diversity promotes evolutionary fitness for binder discovery in a three-helix bundle protein scaffold DR Woldring, PV Holec, LA Stern, Y Du, BJ Hackel Biochemistry 56 (11), 1656-1671, 2017 | 46 | 2017 |
Titratable avidity reduction enhances affinity discrimination in mammalian cellular selections of yeast-displayed ligands LA Stern, CM Csizmar, DR Woldring, CR Wagner, BJ Hackel ACS combinatorial science 19 (5), 315-323, 2017 | 35 | 2017 |
Generative models for protein sequence modeling: recent advances and future directions M Mardikoraem, Z Wang, N Pascual, D Woldring Briefings in Bioinformatics 24 (6), bbad358, 2023 | 24 | 2023 |
64Cu-Labeled Gp2 Domain for PET Imaging of Epidermal Growth Factor Receptor MA Kruziki, BA Case, JY Chan, EJ Zudock, DR Woldring, D Yee, ... Molecular pharmaceutics 13 (11), 3747-3755, 2016 | 22 | 2016 |
Protein fitness prediction is impacted by the interplay of language models, ensemble learning, and sampling methods M Mardikoraem, D Woldring Pharmaceutics 15 (5), 1337, 2023 | 17 | 2023 |
Design and evaluation of engineered extracellular vesicle (EV)-based targeting for EGFR-overexpressing tumor cells using monobody display H Komuro, S Aminova, K Lauro, D Woldring, M Harada Bioengineering 9 (2), 56, 2022 | 16 | 2022 |
ScaffoldSeq: Software for characterization of directed evolution populations DR Woldring, PV Holec, BJ Hackel Proteins: Structure, Function, and Bioinformatics 84 (7), 869-874, 2016 | 14 | 2016 |
Topological deep learning based deep mutational scanning J Chen, DR Woldring, F Huang, X Huang, GW Wei Computers in biology and medicine 164, 107258, 2023 | 11 | 2023 |
Proposed three-phenylalanine motif involved in magnetoreception signalling of an Actinopterygii protein expressed in mammalian cells B Ricker, S Mitra, EA Castellanos, CJ Grady, D Woldring, G Pelled, ... Open Biology 13 (11), 230019, 2023 | 10 | 2023 |
Phytochemical drug discovery for COVID-19 using high-resolution computational docking and machine learning assisted binder prediction Z Wang, T Belecciu, J Eaves, M Reimers, MH Bachmann, D Woldring Journal of Biomolecular Structure and Dynamics 41 (14), 6643-6663, 2023 | 5 | 2023 |
Ancestral sequence reconstruction and alternate amino acid states guide protein library design for directed evolution J VanAntwerp, P Finneran, B Dolgikh, D Woldring Yeast Surface Display, 75-86, 2022 | 5 | 2022 |
Machine learning-driven protein library design: A path toward smarter libraries M Mardikoraem, D Woldring Yeast Surface Display, 87-104, 2022 | 4 | 2022 |
AP-LASR: Automated Protein Libraries from Ancestral Sequence Reconstruction J VanAntwerp, M Mardikoraem, N Pascual, D Woldring bioRxiv, 2023.10. 09.561537, 2023 | 2 | 2023 |
Site-wise diversification of combinatorial libraries using insights from structure-guided stability calculations B Dolgikh, D Woldring Yeast Surface Display, 63-73, 2022 | 2 | 2022 |
Evaluation of High Affinity Scaffolds from High-Throughput Discovery and Targeting DR5 and TNFR1 TL Senkow, DR Woldring, M Kruziki, BJ Hackel, JN Sachs Biophysical Journal 112 (3), 530a, 2017 | 1 | 2017 |
Tumor‐Associated Carbohydrate Antigen 19–9 (CA 19–9), a Promising Target for Antibody‐Based Detection, Diagnosis, and Immunotherapy of Cancer A Nakisa, LF Sempere, X Chen, LT Qu, D Woldring, HC Crawford, ... ChemMedChem 19 (24), e202400491, 2024 | | 2024 |
RecombiCraft library construction: A novel method for DNA library cloning and expansion using non-enzymatic single-step DNA recombination and liquid culture Y Kawai-Harada, M Mardikoraem, K Lauro, V Nimmagadda, Q Tong, ... PloS one 19 (12), e0312188, 2024 | | 2024 |
Predicting Inhibitors of OATP1B1 via Heterogeneous OATP-Ligand Interaction Graph Neural Network (HOLI-GNN) M Mardikoraem, JN Eaves, T Belecciu, N Pascual, A Aljets, BJ Orlando, ... bioRxiv, 2024.10. 01.615464, 2024 | | 2024 |