| Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine RA Seder, LJ Chang, ME Enama, KL Zephir, UN Sarwar, IJ Gordon, ... Science 341 (6152), 1359-1365, 2013 | 967 | 2013 |
| Role of βγ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors JA Pitcher, J Inglese, JB Higgins, JL Arriza, PJ Casey, C Kim, JL Benovic, ... Science 257 (5074), 1264-1267, 1992 | 944 | 1992 |
| Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries J Inglese, DS Auld, A Jadhav, RL Johnson, A Simeonov, A Yasgar, ... Proceedings of the National Academy of Sciences 103 (31), 11473-11478, 2006 | 899 | 2006 |
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012 | 809 | 2012 |
| High-throughput screening assays for the identification of chemical probes J Inglese, RL Johnson, A Simeonov, M Xia, W Zheng, CP Austin, DS Auld Nature chemical biology 3 (8), 466-479, 2007 | 761 | 2007 |
| Protein kinases that phosphorylate activated G protein‐coupled receptors RT Premont, J Inglese, RJ Lefkowitz The FASEB Journal 9 (2), 175-182, 1995 | 676 | 1995 |
| Binding of G protein beta gamma-subunits to pleckstrin homology domains. K Touhara, J Inglese, JA Pitcher, G Shaw, RJ Lefkowitz Journal of Biological Chemistry 269 (14), 10217-10220, 1994 | 635 | 1994 |
| Activation of the cloned muscarinic potassium channel by G protein βγ subunits E Reuveny, PA Slesinger, J Inglese, JM Morales, JA Iñiguez-Lluhi, ... Nature 370 (6485), 143-146, 1994 | 613 | 1994 |
| The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. WJ Koch, J Inglese, WC Stone, RJ Lefkowitz Journal of Biological Chemistry 268 (11), 8256-8260, 1993 | 605 | 1993 |
| Structure and mechanism of the G protein-coupled receptor kinases. J Inglese, NJ Freedman, WJ Koch, RJ Lefkowitz The Journal of biological chemistry 268 (32), 23735-23738, 1993 | 573 | 1993 |
| Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. WJ Koch, BE Hawes, J Inglese, LM Luttrell, RJ Lefkowitz Journal of Biological Chemistry 269 (8), 6193-6197, 1994 | 512 | 1994 |
| Apparent activity in high-throughput screening: origins of compound-dependent assay interference N Thorne, DS Auld, J Inglese Current opinion in chemical biology 14 (3), 315-324, 2010 | 474 | 2010 |
| A high-throughput screen for aggregation-based inhibition in a large compound library BY Feng, A Simeonov, A Jadhav, K Babaoglu, J Inglese, BK Shoichet, ... Journal of medicinal chemistry 50 (10), 2385-2390, 2007 | 427 | 2007 |
| Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases J Inglese, WJ Koch, MG Caron, RJ Lefkowitz Nature 359 (6391), 147-150, 1992 | 394 | 1992 |
| Illuminating insights into firefly luciferase and other bioluminescent reporters used in chemical biology N Thorne, J Inglese, DS Auld Chemistry & biology 17 (6), 646-657, 2010 | 388 | 2010 |
| Ca2+-dependent interaction of recoverin with rhodopsin kinase CK Chen, J Inglese, RJ Lefkowitz, JB Hurley Journal of Biological Chemistry 270 (30), 18060-18066, 1995 | 379 | 1995 |
| A region of adenylyl cyclase 2 critical for regulation by G protein βγ subunits J Chen, M DeVivo, J Dingus, A Harry, J Li, J Sui, DJ Carty, JL Blank, ... Science 268 (5214), 1166-1169, 1995 | 326 | 1995 |
| Identification of oxadiazoles as new drug leads for the control of schistosomiasis AA Sayed, A Simeonov, CJ Thomas, J Inglese, CP Austin, DL Williams Nature medicine 14 (4), 407-412, 2008 | 321 | 2008 |
| Compound cytotoxicity profiling using quantitative high-throughput screening M Xia, R Huang, KL Witt, N Southall, J Fostel, MH Cho, A Jadhav, ... Environmental health perspectives 116 (3), 284-291, 2008 | 303 | 2008 |
| Fluorescence spectroscopic profiling of compound libraries A Simeonov, A Jadhav, CJ Thomas, Y Wang, R Huang, NT Southall, ... Journal of medicinal chemistry 51 (8), 2363-2371, 2008 | 294 | 2008 |
Robert J. LefkowitzJames B. Duke Professor of Medicine, Biochemistry, Chemistry; HHMI, Duke UniversityVerified email at receptor-biol.duke.edu