Christian Frezza

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Ana S. H. CostaMatterworks Inc.Verified email at matterworks.ai
Edoardo GaudePOCKiT diagnostics LtdVerified email at pockitdx.co.uk
Eyal GottliebThe University of Texas, MD Anderson Cancer CenterVerified email at mdanderson.org
Michael P MurphyMRC Mitochondrial BIology Unit, University of CambridgeVerified email at mrc-mbu.cam.ac.uk
Marco SciacovelliDepartment of Molecular and Clinical Cancer Medicine-University of LiverpoolVerified email at liverpool.ac.uk
Luca ScorranoUniversity of Padova, Italy and VIMM, Padova, ItalyVerified email at unipd.it
Dylan Gerard RyanResearch associate, University of CambridgeVerified email at cam.ac.uk
Eytan RuppinChief, Cancer Data Science Lab (CDSL), NCI/NIHVerified email at nih.gov
Luke O'NeillTrinity College DublinVerified email at tcd.ie
Kourosh Saeb-ParsyProfessor of Transplantation, University of CambridgeVerified email at cam.ac.uk
Stefano PluchinoClinical Professor of Regenerative Neuroimmunology at Cambridge UniversityVerified email at cam.ac.uk
Victoria PellPost-doctoral Researcher, Kings College LondonVerified email at kcl.ac.uk
Hiran A. PragPost-Doctoral Research Associate, University of CambridgeVerified email at cam.ac.uk
Andrew M JamesUniversity of CambridgeVerified email at mrc-mbu.cam.ac.uk
Ed ChouchaniProfessor - Dana-Farber Cancer Institute / Harvard Medical SchoolVerified email at dfci.harvard.edu
Bart De Stroopergewoon hoogleraar KU Leuven en onderzoeksdirecteur VIBVerified email at cme.vib-kuleuven.be
Julio Saez RodriguezHeidelberg UniversityVerified email at uni-heidelberg.de
Evanna L. MillsHarvard Medical SchoolVerified email at tcd.ie
Eamonn MaherAston UniversityVerified email at aston.ac.uk
Dr. Christina SchmidtInstitute of Computational Biomedicine, University Hospital HeidelbergVerified email at uni-heidelberg.de

Christian Frezza

CECAD, University of Cologne

Verified email at uni-koeln.de - Homepage

cancer metabolism mitochondria


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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹ DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021	13600*	2021
Succinate is an inflammatory signal that induces IL-1β through HIF-1α GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, ... Nature 496 (7444), 238-242, 2013	3840	2013
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS ET Chouchani, VR Pell, E Gaude, D Aksentijević, SY Sundier, EL Robb, ... Nature 515 (7527), 431-435, 2014	2743	2014
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages EL Mills, B Kelly, A Logan, ASH Costa, M Varma, CE Bryant, ... Cell 167 (2), 457-470. e13, 2016	1966	2016
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion C Frezza, S Cipolat, OM De Brito, M Micaroni, GV Beznoussenko, ... Cell 126 (1), 177-189, 2006	1892	2006
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018	1546	2018
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts C Frezza, S Cipolat, L Scorrano Nature protocols 2 (2), 287-295, 2007	1338	2007
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency S Cogliati, C Frezza, ME Soriano, T Varanita, R Quintana-Cabrera, ... Cell 155 (1), 160-171, 2013	1308	2013
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling S Cipolat, T Rudka, D Hartmann, V Costa, L Serneels, K Craessaerts, ... Cell 126 (1), 163-175, 2006	880	2006
A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury ET Chouchani, VR Pell, AM James, LM Work, K Saeb-Parsy, C Frezza, ... Cell metabolism 23 (2), 254-263, 2016	743	2016
Serine is a natural ligand and allosteric activator of pyruvate kinase M2 B Chaneton, P Hillmann, L Zheng, ACL Martin, ODK Maddocks, ... Nature 491 (7424), 458-462, 2012	693	2012
A roadmap for interpreting 13C metabolite labeling patterns from cells JM Buescher, MR Antoniewicz, LG Boros, SC Burgess, H Brunengraber, ... Current opinion in biotechnology 34, 189-201, 2015	675	2015
Serine is an essential metabolite for effector T cell expansion EH Ma, G Bantug, T Griss, S Condotta, RM Johnson, B Samborska, ... Cell metabolism 25 (2), 345-357, 2017	653	2017
Predicting selective drug targets in cancer through metabolic networks O Folger, L Jerby, C Frezza, E Gottlieb, E Ruppin, T Shlomi Molecular systems biology 7 (1), 501, 2011	612	2011
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition M Sciacovelli, E Gonçalves, TI Johnson, VR Zecchini, ASH Da Costa, ... Nature 537 (7621), 544-547, 2016	575	2016
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase C Frezza, L Zheng, O Folger, KN Rajagopalan, ED MacKenzie, L Jerby, ... Nature 477 (7363), 225-228, 2011	566	2011
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function VA Morais, P Verstreken, A Roethig, J Smet, A Snellinx, M Vanbrabant, ... EMBO molecular medicine 1 (2), 99-111, 2009	469	2009
Coupling Krebs cycle metabolites to signalling in immunity and cancer DG Ryan, MP Murphy, C Frezza, HA Prag, ET Chouchani, LA O’Neill, ... Nature metabolism 1 (1), 16-33, 2019	363	2019
Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival E Gaude, C Frezza Nature communications 7 (1), 13041, 2016	359	2016
Mitochondria in cancer: not just innocent bystanders C Frezza, E Gottlieb Seminars in cancer biology 19 (1), 4-11, 2009	357	2009

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