13C metabolic flux analysis W Wiechert Metabolic engineering 3 (3), 195-206, 2001 | 1071 | 2001 |
Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite … A Marx, AA de Graaf, W Wiechert, L Eggeling, H Sahm Biotechnology and bioengineering 49 (2), 111-129, 1996 | 455 | 1996 |
A universal framework for 13C metabolic flux analysis W Wiechert, M Möllney, S Petersen, AA De Graaf Metabolic engineering 3 (3), 265-283, 2001 | 441 | 2001 |
Bidirectional reaction steps in metabolic networks: III. Explicit solution and analysis of isotopomer labeling systems W Wiechert, M Möllney, N Isermann, M Wurzel, AA de Graaf Biotechnology and bioengineering 66 (2), 69-85, 1999 | 370 | 1999 |
Bidirectional reaction steps in metabolic networks: I. Modeling and simulation of carbon isotope labeling experiments W Wiechert, AA de Graaf Biotechnology and bioengineering 55 (1), 101-117, 1997 | 349 | 1997 |
Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms N Paczia, A Nilgen, T Lehmann, J Gätgens, W Wiechert, S Noack Microbial cell factories 11, 1-14, 2012 | 316 | 2012 |
Bidirectional reaction steps in metabolic networks: II. Flux estimation and statistical analysis W Wiechert, C Siefke, AA de Graaf, A Marx Biotechnology and bioengineering 55 (1), 118-135, 1997 | 312 | 1997 |
Modeling and simulation: tools for metabolic engineering W Wiechert Journal of biotechnology 94 (1), 37-63, 2002 | 287 | 2002 |
Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments K Nöh, K Grönke, B Luo, R Takors, M Oldiges, W Wiechert Journal of biotechnology 129 (2), 249-267, 2007 | 265 | 2007 |
Bidirectional reaction steps in metabolic networks: IV. Optimal design of isotopomer labeling experiments M Möllney, W Wiechert, D Kownatzki, AA de Graaf Biotechnology and bioengineering 66 (2), 86-103, 1999 | 251 | 1999 |
13CFLUX2—high-performance software suite for 13C-metabolic flux analysis M Weitzel, K Nöh, T Dalman, S Niedenführ, B Stute, W Wiechert Bioinformatics 29 (1), 143-145, 2013 | 250 | 2013 |
In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum S Petersen, AA de Graaf, L Eggeling, M Mollney, W Wiechert, H Sahm Journal of Biological Chemistry 275 (46), 35932-35941, 2000 | 237 | 2000 |
New tools for mass isotopomer data evaluation in 13C flux analysis: Mass isotope correction, data consistency checking, and precursor relationships SA Wahl, M Dauner, W Wiechert Biotechnology and Bioengineering 85 (3), 259-268, 2004 | 208 | 2004 |
Single-cell microfluidics: opportunity for bioprocess development A Grünberger, W Wiechert, D Kohlheyer Current opinion in biotechnology 29, 15-23, 2014 | 196 | 2014 |
Microbioreactor systems for accelerated bioprocess development J Hemmerich, S Noack, W Wiechert, M Oldiges Biotechnology journal 13 (4), 1700141, 2018 | 176 | 2018 |
13C-flux spectral analysis of host-pathogen metabolism reveals a mixed diet for intracellular Mycobacterium tuberculosis DJV Beste, K Nöh, S Niedenführ, TA Mendum, ND Hawkins, JL Ward, ... Chemistry & biology 20 (8), 1012-1021, 2013 | 161 | 2013 |
From stationary to instationary metabolic flux analysis W Wiechert, K Nöh Technology Transfer in Biotechnology: From Lab to Industry to Production …, 2005 | 155 | 2005 |
Emerging Corynebacterium glutamicum systems biology VF Wendisch, M Bott, J Kalinowski, M Oldiges, W Wiechert Journal of biotechnology 124 (1), 74-92, 2006 | 152 | 2006 |
Optical sensors for monitoring dynamic changes of intracellular metabolite levels in mammalian cells BH Hou, H Takanaga, G Grossmann, LQ Chen, XQ Qu, AM Jones, ... Nature protocols 6 (11), 1818-1833, 2011 | 141 | 2011 |
A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level A Grünberger, N Paczia, C Probst, G Schendzielorz, L Eggeling, S Noack, ... Lab on a Chip 12 (11), 2060-2068, 2012 | 136 | 2012 |