| Expanding the genetic code of Escherichia coli with phosphoserine HS Park, MJ Hohn, T Umehara, LT Guo, EM Osborne, J Benner, CJ Noren, ... Science 333 (6046), 1151-1154, 2011 | 442 | 2011 |
| Continuous directed evolution of aminoacyl-tRNA synthetases DI Bryson, C Fan, LT Guo, C Miller, D Söll, DR Liu Nature chemical biology 13 (12), 1253-1260, 2017 | 280 | 2017 |
| Protein aggregation caused by aminoglycoside action is prevented by a hydrogen peroxide scavenger J Ling, C Cho, LT Guo, HR Aerni, J Rinehart, D Söll Molecular cell 48 (5), 713-722, 2012 | 136 | 2012 |
| Polyspecific pyrrolysyl-tRNA synthetases from directed evolution LT Guo, YS Wang, A Nakamura, D Eiler, JM Kavran, M Wong, ... Proceedings of the National Academy of Sciences 111 (47), 16724-16729, 2014 | 133 | 2014 |
| Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase T Suzuki, C Miller, LT Guo, JML Ho, DI Bryson, YS Wang, DR Liu, D Söll Nature chemical biology 13 (12), 1261-1266, 2017 | 111 | 2017 |
| N-acetyl lysyl-tRNA synthetases evolved by a CcdB-based selection possess N-acetyl lysine specificity in vitro and in vivo T Umehara, J Kim, S Lee, LT Guo, D Söll, HS Park FEBS letters 586 (6), 729-733, 2012 | 108 | 2012 |
| Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity N Shen, L Guo, B Yang, Y Jin, J Ding Nucleic acids research 34 (11), 3246-3258, 2006 | 73 | 2006 |
| Sequencing and structure probing of long RNAs using MarathonRT: a next-generation reverse transcriptase LT Guo, RL Adams, H Wan, NC Huston, O Potapova, S Olson, ... Journal of molecular biology 432 (10), 3338-3352, 2020 | 58 | 2020 |
| Efficient Reassignment of a Frequent Serine Codon in Wild-Type Escherichia coli JM Ho, NM Reynolds, K Rivera, M Connolly, LT Guo, J Ling, DJ Pappin, ... ACS synthetic biology 5 (2), 163-171, 2016 | 45 | 2016 |
| Pyrrolysyl‐tRNA synthetase variants reveal ancestral aminoacylation function J Ko, YS Wang, A Nakamura, LT Guo, D Söll, T Umehara FEBS letters 587 (19), 3243-3248, 2013 | 42 | 2013 |
| Probing the active site tryptophan of Staphylococcus aureus thioredoxin with an analog DSLTG Markus Englert, Akiyoshi Nakamura, Yane-Shih Wang, Daniel Eiler Nucl. Acids Res., 2015 | 29 | 2015 |
| Ancestral archaea expanded the genetic code with pyrrolysine LT Guo, K Amikura, HK Jiang, T Mukai, X Fu, YS Wang, P O’Donoghue, ... Journal of Biological Chemistry 298 (11), 2022 | 19 | 2022 |
| Rational design and directed evolution of a bacterial-type glutaminyl-tRNA synthetase precursor LT Guo, S Helgadottir, D Söll, J Ling Nucleic acids research 40 (16), 7967-7974, 2012 | 19 | 2012 |
| Direct tracking of reverse-transcriptase speed and template sensitivity: implications for sequencing and analysis of long RNA molecules LT Guo, S Olson, S Patel, BR Graveley, AM Pyle Nucleic Acids Research 50 (12), 6980-6989, 2022 | 18 | 2022 |
| Residues Lys-149 and Glu-153 switch the aminoacylation of tRNATrp in Bacillus subtilis J Jia, XL Chen, LT Guo, YD Yu, JP Ding, YX Jin Journal of Biological Chemistry 279 (40), 41960-41965, 2004 | 10 | 2004 |
| Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311 LT Guo, XL Chen, BT Zhao, Y Shi, W Li, H Xue, YX Jin Nucleic acids research 35 (17), 5934-5943, 2007 | 8 | 2007 |
| Characterization and implementation of the MarathonRT template-switching reaction to expand the capabilities of RNA-seq LT Guo, A Grinko, S Olson, AM Leipold, B Graveley, AE Saliba, AM Pyle RNA 30 (11), 1495-1512, 2024 | 1 | 2024 |
| End-to-end RT-PCR of long RNA and highly structured RNA LT Guo, AM Pyle Methods in Enzymology 691, 3-15, 2023 | 1 | 2023 |
| Erratum: Continuous directed evolution of aminoacyl-tRNA synthetases DI Bryson, C Fan, LT Guo, C Miller, D Söll, DR Liu Nature Chemical Biology 14 (2), 186-186, 2018 | 1 | 2018 |
| Evaluating reverse transcriptases processivity at the single-molecule and bulk levels T Tzadikario, Y Yee, S Noh, F Farhangdoust, LT Guo, M Scanlon, AM Pyle, ... Biophysical Journal 123 (3), 223a, 2024 | | 2024 |
Takuya UmeharaUniversity of TokyoVerified email at mail.ecc.u-tokyo.ac.jp
