| The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model A Doran, RS Obach, BJ Smith, NA Hosea, S Becker, E Callegari, C Chen, ... Drug Metabolism and Disposition 33 (1), 165-174, 2005 | 529 | 2005 |
| Plasma‐pooling methods to increase throughput for in vivo pharmacokinetic screening CECA Hop, Z Wang, Q Chen, G Kwei Journal of pharmaceutical sciences 87 (7), 901-903, 1998 | 254 | 1998 |
| Interindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem … B Prasad, R Evers, A Gupta, CECA Hop, L Salphati, S Shukla, ... Drug Metabolism and Disposition 42 (1), 78-88, 2014 | 206 | 2014 |
| Strategies for characterization of drug metabolites using liquid chromatography–tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange … DQ Liu, CECA Hop Journal of pharmaceutical and biomedical analysis 37 (1), 1-18, 2005 | 204 | 2005 |
| Interspecies variability in expression of hepatobiliary transporters across human, dog, monkey, and rat as determined by quantitative proteomics L Wang, B Prasad, L Salphati, X Chu, A Gupta, CECA Hop, R Evers, ... Drug Metabolism and Disposition 43 (3), 367-374, 2015 | 201 | 2015 |
| Rational use of plasma protein and tissue binding data in drug design: miniperspective X Liu, M Wright, CECA Hop Journal of medicinal chemistry 57 (20), 8238-8248, 2014 | 177 | 2014 |
| Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4 AS Kalgutkar, ADN Vaz, ME Lame, KR Henne, J Soglia, SX Zhao, ... Drug metabolism and disposition 33 (2), 243-253, 2005 | 173 | 2005 |
| Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein GY Kwei, RF Alvaro, Q Chen, HJ Jenkins, C Hop, CA Keohane, VT Ly, ... Drug Metabolism and Disposition 27 (5), 581-587, 1999 | 169 | 1999 |
| Ontogeny of hepatic drug transporters as quantified by LC‐MS/MS proteomics B Prasad, A Gaedigk, M Vrana, R Gaedigk, JS Leeder, L Salphati, X Chu, ... Clinical Pharmacology & Therapeutics 100 (4), 362-370, 2016 | 148 | 2016 |
| Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response H Wong, EF Choo, B Alicke, X Ding, H La, E McNamara, FP Theil, ... Clinical Cancer Research 18 (14), 3846-3855, 2012 | 142 | 2012 |
| Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine SK Balani, X Xu, BH Arison, MV Silva, A Gries, FA DeLuna, D Cui, PH Kari, ... Drug metabolism and disposition 28 (11), 1274-1278, 2000 | 138 | 2000 |
| Determination of in vitro permeability of drug candidates through a Caco‐2 cell monolayer by liquid chromatography/tandem mass spectrometry Z Wang, CECA Hop, KH Leung, JM Pang Journal of mass spectrometry 35 (1), 71-76, 2000 | 125 | 2000 |
| Transporter expression in liver tissue from subjects with alcoholic or hepatitis C cirrhosis quantified by targeted quantitative proteomics L Wang, C Collins, EJ Kelly, X Chu, AS Ray, L Salphati, G Xiao, C Lee, ... Drug Metabolism and Disposition 44 (11), 1752-1758, 2016 | 118 | 2016 |
| In vitro–in vivo extrapolation of clearance: modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods P Poulin, JR Kenny, CECA Hop, S Haddad Journal of pharmaceutical sciences 101 (2), 838-851, 2012 | 117 | 2012 |
| A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography− tandem mass spectrometry and novel quaternary … JR Soglia, LG Contillo, AS Kalgutkar, S Zhao, CECA Hop, JG Boyd, ... Chemical research in toxicology 19 (3), 480-490, 2006 | 114 | 2006 |
| A decade in the MIST: learnings from investigations of drug metabolites in drug development under the “metabolites in safety testing” regulatory guidance S Schadt, B Bister, SK Chowdhury, C Funk, CECA Hop, WG Humphreys, ... Drug Metabolism and Disposition 46 (6), 865-878, 2018 | 113 | 2018 |
| Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase JE Stelmach, L Liu, SB Patel, JV Pivnichny, G Scapin, S Singh, ... Bioorganic & medicinal chemistry letters 13 (2), 277-280, 2003 | 106 | 2003 |
| Opportunities and challenges using artificial intelligence in ADME/Tox B Bhhatarai, WP Walters, CECA Hop, G Lanza, S Ekins Nature materials 18 (5), 418-422, 2019 | 105 | 2019 |
| Drug concentration asymmetry in tissues and plasma for small molecule–related therapeutic modalities D Zhang, CECA Hop, G Patilea-Vrana, G Gampa, HK Seneviratne, ... Drug Metabolism and Disposition 47 (10), 1122-1135, 2019 | 102 | 2019 |
| Toward a consensus on applying quantitative liquid chromatography‐tandem mass spectrometry proteomics in translational pharmacology research: a white paper B Prasad, B Achour, P Artursson, CECA Hop, Y Lai, PC Smith, J Barber, ... Clinical Pharmacology & Therapeutics 106 (3), 525-543, 2019 | 96 | 2019 |
