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Aleksey I. Gerasyuto
Aleksey I. Gerasyuto
Senior Research Leader, Medicinal Chemistry, Schrödinger
Verified email at schrodinger.com
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Cited by
Year
Stereoselective Formal [3 + 3] Cycloaddition Approach to cis-1-Azadecalins and Synthesis of (−)-4a,8a-diepi-Pumiliotoxin C. Evidence for the First Highly …
HM Sklenicka, RP Hsung, MJ McLaughlin, L Wei, AI Gerasyuto, ...
Journal of the American Chemical Society 124 (35), 10435-10442, 2002
1222002
A Novel and Highly Stereoselective Intramolecular Formal [3+3] Cycloaddition Reaction of Vinylogous Amides Tethered with α,β‐Unsaturated Aldehydes: A …
LL Wei, RP Hsung, HM Sklenicka, AI Gerasyuto
Angewandte Chemie 113 (8), 1564-1566, 2001
1162001
A formal [3+ 3] cycloaddition reaction. 5. An enantioselective intramolecular formal aza-[3+ 3] cycloaddition reaction promoted by chiral amine salts
AI Gerasyuto, RP Hsung, N Sydorenko, B Slafer
The Journal of Organic Chemistry 70 (11), 4248-4256, 2005
862005
A formal [3+ 3] cycloaddition reaction. improved reactivity using α, β-unsaturated iminium salts and evidence for reversibility of 6π-electron electrocyclic ring closure of 1 …
HC Shen, J Wang, KP Cole, MJ McLaughlin, CD Morgan, CJ Douglas, ...
The Journal of Organic Chemistry 68 (5), 1729-1735, 2003
852003
Highly Stereoselective Formal [3+ 3] Cycloaddition Reactions of Chiral Vinylogous Amides with α, β-Unsaturated Iminiums
HM Sklenicka, RP Hsung, LL Wei, MJ McLaughlin, AI Gerasyuto, ...
Organic Letters 2 (8), 1161-1164, 2000
682000
An Intramolecular aza-[3 + 3] Annulation Approach to Azaphenalene Alkaloids. Total Synthesis of Myrrhine
AI Gerasyuto, RP Hsung
The Journal of Organic Chemistry 72 (7), 2476-2484, 2007
452007
Total syntheses of enantiomerically enriched R-(+)-and S-(−)-deplancheine
N Sydorenko, CA Zificsak, AI Gerasyuto, RP Hsung
Organic & Biomolecular Chemistry 3 (11), 2140-2144, 2005
412005
Stereodivergent total syntheses of precoccinelline, hippodamine, coccinelline, and convergine
AI Gerasyuto, RP Hsung
Organic Letters 8 (21), 4899-4902, 2006
392006
Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series
MJ Palmer, X Deng, S Watts, G Krilov, A Gerasyuto, S Kokkonda, ...
Journal of medicinal chemistry 64 (9), 6085-6136, 2021
352021
Asymmetric Aza-[3 + 3] Annulation in the Synthesis of Indolizidines: An Unexpected Reversal of Regiochemistry
GS Buchanan, H Dai, RP Hsung, AI Gerasyuto, CM Scheinebeck
Organic letters 13 (16), 4402-4405, 2011
312011
Organocatalyzed [3+ 3] Annulations for the Construction of Heterocycles
Y Zhu, Y Huang
Synthesis 52 (08), 1181-1202, 2020
272020
Inhibitors of (alpha-v)(beta-6) integrin
BA Harrison, MG Bursavich, M Brewer, AI Gerasyuto, KN Hahn, KD Konze, ...
US Patent App. 15/906,745, 2018
192018
Ribonucleotide reductase, a novel drug target for gonorrhea
J Narasimhan, S Letinski, SP Jung, A Gerasyuto, J Wang, M Arnold, ...
Elife 11, e67447, 2022
142022
Discovery and optimization of indolyl-containing 4-hydroxy-2-pyridone type II DNA topoisomerase inhibitors active against multidrug resistant gram-negative bacteria
AI Gerasyuto, MA Arnold, J Wang, G Chen, X Zhang, S Smith, MG Woll, ...
Journal of medicinal chemistry 61 (10), 4456-4475, 2018
142018
Synthesis of 2, 3-Dihydrobenzothiazol-1, 1-dioxide and 2, 3-Dihydro-1, 4-benzothiazin-3-one Nitroderivatives from 2, 4-Di-and 2, 4, 6-Trinitrobenzamides
AI Gerasyuto, SG Zlotin, VV Semenov
Synthesis 2001 (02), 0300-0304, 2001
122001
4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis
MA Arnold, AI Gerasyuto, J Wang, W Du, YJK Gorske, T Arasu, J Baird, ...
Bioorganic & Medicinal Chemistry Letters 27 (22), 5014-5021, 2017
92017
Inhibiting (alpha-v)(beta-6) integrin
BA Harrison, JE Dowling, MG Bursavich, DM Troast, BS Lippa, BN Rogers, ...
US Patent App. 16/555,589, 2020
82020
Establishing the concept of aza-[3+ 3] annulations using enones as a key expansion of this unified strategy in alkaloid synthesis
AI Gerasyuto, ZX Ma, GS Buchanan, RP Hsung
Beilstein Journal of Organic Chemistry 9 (1), 1170-1178, 2013
82013
Inhibitors of (α-v)(β-6) integrin
BA Harrison, MG Bursavich, M Brewer, AI Gerasyuto, KN Hahn, KD Konze, ...
US Patent 11,046,669, 2021
72021
Inhibitors of (α-v)(β-6) integrin
BA Harrison, MG Bursavich, AI Gerasyuto, KN Hahn, KD Konze, FY Lin, ...
US Patent 11,046,685, 2021
72021
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