| Expanding the genetic code of Escherichia coli with phosphoserine HS Park, MJ Hohn, T Umehara, LT Guo, EM Osborne, J Benner, CJ Noren, ... Science 333 (6046), 1151-1154, 2011 | 442 | 2011 |
| Pyrrolysyl-tRNA synthetase–tRNAPyl structure reveals the molecular basis of orthogonality K Nozawa, P O’Donoghue, S Gundllapalli, Y Araiso, R Ishitani, ... Nature 457 (7233), 1163-1167, 2009 | 219 | 2009 |
| Evaluation of a cyclophilin inhibitor in hepatitis C virus–infected chimeric mice in vivo K Inoue, T Umehara, UT Ruegg, F Yasui, T Watanabe, H Yasuda, ... Hepatology 45 (4), 921-928, 2007 | 142 | 2007 |
| Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice S Nakagawa, T Umehara, C Matsuda, S Kuge, M Sudoh, M Kohara Biochemical and biophysical research communications 353 (4), 882-888, 2007 | 134 | 2007 |
| N-acetyl lysyl-tRNA synthetases evolved by a CcdB-based selection possess N-acetyl lysine specificity in vitro and in vivo T Umehara, J Kim, S Lee, LT Guo, D Söll, HS Park FEBS letters 586 (6), 729-733, 2012 | 108 | 2012 |
| A hepatitis C virus (HCV) internal ribosome entry site (IRES) domain III–IV-targeted aptamer inhibits translation by binding to an apical loop of domain IIId K Kikuchi, T Umehara, K Fukuda, A Kuno, T Hasegawa, S Nishikawa Nucleic acids research 33 (2), 683-692, 2005 | 103 | 2005 |
| Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome T Watanabe, T Umehara, F Yasui, S Nakagawa, J Yano, T Ohgi, ... Journal of hepatology 47 (6), 744-750, 2007 | 95 | 2007 |
| Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis Y Hirata, K Ikeda, M Sudoh, Y Tokunaga, A Suzuki, L Weng, M Ohta, ... Public Library of Science 8 (8), e1002860, 2012 | 87 | 2012 |
| RNA aptamers targeted to domain II of hepatitis C virus IRES that bind to its apical loop region K Kikuchi, T Umehara, K Fukuda, J Hwang, A Kuno, T Hasegawa, ... Journal of biochemistry 133 (3), 263-270, 2003 | 85 | 2003 |
| Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model T Umehara, M Sudoh, F Yasui, C Matsuda, Y Hayashi, K Chayama, ... Biochemical and biophysical research communications 346 (1), 67-73, 2006 | 84 | 2006 |
| Therapeutic application of RNA interference for hepatitis C virus T Watanabe, T Umehara, M Kohara Advanced drug delivery reviews 59 (12), 1263-1276, 2007 | 66 | 2007 |
| Rational design of dual-functional aptamers that inhibit the protease and helicase activities of HCV NS3 T Umehara, K Fukuda, F Nishikawa, M Kohara, T Hasegawa, S Nishikawa Journal of biochemistry 137 (3), 339-347, 2005 | 57 | 2005 |
| Increased inhibitory ability of conjugated RNA aptamers against the HCV IRES K Kikuchi, T Umehara, F Nishikawa, K Fukuda, T Hasegawa, S Nishikawa Biochemical and biophysical research communications 386 (1), 118-123, 2009 | 53 | 2009 |
| An RNA ligand inhibits hepatitis C virus NS3 protease and helicase activities K Fukuda, T Umehara, S Sekiya, K Kunio, T Hasegawa, S Nishikawa Biochemical and biophysical research communications 325 (3), 670-675, 2004 | 50 | 2004 |
| Pyrrolysyl‐tRNA synthetase variants reveal ancestral aminoacylation function J Ko, YS Wang, A Nakamura, LT Guo, D Söll, T Umehara FEBS letters 587 (19), 3243-3248, 2013 | 42 | 2013 |
| RNA-dependent cysteine biosynthesis in bacteria and archaea T Mukai, A Crnković, T Umehara, NN Ivanova, NC Kyrpides, D Söll MBio 8 (3), 10.1128/mbio. 00561-17, 2017 | 24 | 2017 |
| Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3 T Umehara, K Fukuda, F Nishikawa, S Sekiya, M Kohara, T Hasegawa, ... Nucleic Acids Symposium Series 48 (1), 195-196, 2004 | 24 | 2004 |
| Peptide bond formation between aminoacyl-minihelices by a scaffold derived from the peptidyl transferase center M Kawabata, K Kawashima, H Mutsuro-Aoki, T Ando, T Umehara, ... Life 12 (4), 573, 2022 | 18 | 2022 |
| Glycols modulate terminator stem stability and ligand-dependency of a glycine riboswitch K Hamachi, H Hayashi, M Shimamura, Y Yamaji, A Kaneko, A Fujisawa, ... BioSystems 113 (2), 59-65, 2013 | 18 | 2013 |
| Amino acid activation analysis of primitive aminoacyl-tRNA synthetases encoded by both strands of a single gene using the malachite green assay K Onodera, N Suganuma, H Takano, Y Sugita, T Shoji, A Minobe, ... BioSystems 208, 104481, 2021 | 17 | 2021 |
