| p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription A Jain, T Lamark, E Sjøttem, KB Larsen, JA Awuh, A Øvervatn, ... Journal of biological chemistry 285 (29), 22576-22591, 2010 | 1541 | 2010 |
| Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression M McMahon, K Itoh, M Yamamoto, JD Hayes Journal of Biological Chemistry 278 (24), 21592-21600, 2003 | 1315 | 2003 |
| NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer JD Hayes, M McMahon Trends in biochemical sciences 34 (4), 176-188, 2009 | 1039 | 2009 |
| SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner P Rada, AI Rojo, S Chowdhry, M McMahon, JD Hayes, A Cuadrado Molecular and cellular biology 31 (6), 1121-1133, 2011 | 853 | 2011 |
| The Cap ‘n’Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification … M McMahon, K Itoh, M Yamamoto, SA Chanas, CJ Henderson, ... Cancer research 61 (8), 3299-3307, 2001 | 816 | 2001 |
| Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity S Chowdhry, Y Zhang, M McMahon, C Sutherland, A Cuadrado, ... Oncogene 32 (32), 3765-3781, 2013 | 715 | 2013 |
| Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway JD Hayes, M McMahon, S Chowdhry, AT Dinkova-Kostova Antioxidants & redox signaling 13 (11), 1713-1748, 2010 | 641 | 2010 |
| Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study RA Evans, HJC McAuley, EM Harrison, A Shikotra, A Singapuri, M Sereno, ... The Lancet Respiratory Medicine 9 (11), 1275-1287, 2021 | 602 | 2021 |
| Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD (P) H: quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence P Nioi, M McMahon, K Itoh, M Yamamoto, JD Hayes Biochemical Journal 374 (2), 337-348, 2003 | 592 | 2003 |
| Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a “tethering” mechanism: a two-site interaction model for the Nrf2-Keap1 complex M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes Journal of Biological Chemistry 281 (34), 24756-24768, 2006 | 576 | 2006 |
| Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes Journal of Biological Chemistry 279 (30), 31556-31567, 2004 | 548 | 2004 |
| Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and … SA Chanas, Q Jiang, M McMahon, GK McWalter, LI McLellan, ... Biochemical Journal 365 (2), 405-416, 2002 | 543 | 2002 |
| Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals M McMahon, DJ Lamont, KA Beattie, JD Hayes Proceedings of the National Academy of Sciences 107 (44), 18838-18843, 2010 | 487 | 2010 |
| The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic … JD Hayes, SA Chanas, CJ Henderson, M McMahon, C Sun, GJ Moffat, ... Biochemical Society Transactions 28 (2), 33-41, 2000 | 434 | 2000 |
| Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention JD Hayes, M McMahon Cancer letters 174 (2), 103-113, 2001 | 415 | 2001 |
| Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study RA Evans, OC Leavy, M Richardson, O Elneima, HJC McAuley, ... The Lancet Respiratory Medicine 10 (8), 761-775, 2022 | 384 | 2022 |
| Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway … AK MacLeod, M McMahon, SM Plummer, LG Higgins, TM Penning, ... Carcinogenesis 30 (9), 1571-1580, 2009 | 368 | 2009 |
| Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome Y Katoh, K Iida, MIL Kang, A Kobayashi, M Mizukami, KI Tong, ... Archives of biochemistry and biophysics 433 (2), 342-350, 2005 | 261 | 2005 |
| Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice CEP Goldring, NR Kitteringham, R Elsby, LE Randle, YN Clement, ... Hepatology 39 (5), 1267-1276, 2004 | 254 | 2004 |
| Antioxidant and cytoprotective responses to redox stress J Mathers, JA Fraser, M McMahon, RDC Saunders, JD Hayes, ... Biochemical Society Symposia 71, 157-176, 2004 | 187 | 2004 |
John D HayesScotlandVerified email at dundee.ac.uk
