| Genome editing with engineered zinc finger nucleases FD Urnov, EJ Rebar, MC Holmes, HS Zhang, PD Gregory Nature Reviews Genetics 11 (9), 636-646, 2010 | 3178 | 2010 |
| A TALE nuclease architecture for efficient genome editing JC Miller, S Tan, G Qiao, KA Barlow, J Wang, DF Xia, X Meng, ... Nature biotechnology 29 (2), 143-148, 2011 | 3041 | 2011 |
| Highly efficient endogenous human gene correction using designed zinc-finger nucleases FD Urnov, JC Miller, YL Lee, CM Beausejour, JM Rock, S Augustus, ... Nature 435 (7042), 646-651, 2005 | 2235 | 2005 |
| Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV P Tebas, D Stein, WW Tang, I Frank, SQ Wang, G Lee, SK Spratt, ... New England Journal of Medicine 370 (10), 901-910, 2014 | 1775 | 2014 |
| Genetic engineering of human pluripotent cells using TALE nucleases D Hockemeyer, H Wang, S Kiani, CS Lai, Q Gao, JP Cassady, GJ Cost, ... Nature biotechnology 29 (8), 731-734, 2011 | 1591 | 2011 |
| An improved zinc-finger nuclease architecture for highly specific genome editing JC Miller, MC Holmes, J Wang, DY Guschin, YL Lee, I Rupniewski, ... Nature biotechnology 25 (7), 778-785, 2007 | 1533 | 2007 |
| Distinct factors control histone variant H3. 3 localization at specific genomic regions AD Goldberg, LA Banaszynski, KM Noh, PW Lewis, SJ Elsaesser, ... Cell 140 (5), 678-691, 2010 | 1416 | 2010 |
| Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases EE Perez, J Wang, JC Miller, Y Jouvenot, KA Kim, O Liu, N Wang, G Lee, ... Nature biotechnology 26 (7), 808-816, 2008 | 1412 | 2008 |
| Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases D Hockemeyer, F Soldner, C Beard, Q Gao, M Mitalipova, RC DeKelver, ... Nature biotechnology 27 (9), 851-857, 2009 | 1320 | 2009 |
| Precise genome modification in the crop species Zea mays using zinc-finger nucleases VK Shukla, Y Doyon, JC Miller, RC DeKelver, EA Moehle, SE Worden, ... Nature 459 (7245), 437-441, 2009 | 1232 | 2009 |
| Knockout rats via embryo microinjection of zinc-finger nucleases AM Geurts, GJ Cost, Y Freyvert, B Zeitler, JC Miller, VM Choi, SS Jenkins, ... Science 325 (5939), 433-433, 2009 | 1228 | 2009 |
| Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery A Lombardo, P Genovese, CM Beausejour, S Colleoni, YL Lee, KA Kim, ... Nature biotechnology 25 (11), 1298-1306, 2007 | 1180 | 2007 |
| Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases Y Doyon, JM McCammon, JC Miller, F Faraji, C Ngo, GE Katibah, ... Nature biotechnology 26 (6), 702-708, 2008 | 1170 | 2008 |
| Histone deimination antagonizes arginine methylation GL Cuthbert, S Daujat, AW Snowden, H Erdjument-Bromage, T Hagiwara, ... Cell 118 (5), 545-553, 2004 | 1101 | 2004 |
| Targeted genome editing across species using ZFNs and TALENs AJ Wood, TW Lo, B Zeitler, CS Pickle, EJ Ralston, AH Lee, R Amora, ... Science 333 (6040), 307-307, 2011 | 985 | 2011 |
| Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations F Soldner, J Laganière, AW Cheng, D Hockemeyer, Q Gao, R Alagappan, ... Cell 146 (2), 318-331, 2011 | 947 | 2011 |
| Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor W Deng, J Lee, H Wang, J Miller, A Reik, PD Gregory, A Dean, GA Blobel Cell 149 (6), 1233-1244, 2012 | 857 | 2012 |
| Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo N Holt, J Wang, K Kim, G Friedman, X Wang, V Taupin, GM Crooks, ... Nature biotechnology 28 (8), 839-847, 2010 | 848 | 2010 |
| Knockout rats generated by embryo microinjection of TALENs L Tesson, C Usal, S Ménoret, E Leung, BJ Niles, S Remy, Y Santiago, ... Nature biotechnology 29 (8), 695-696, 2011 | 835 | 2011 |
| K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates J Straimer, NF Gnädig, B Witkowski, C Amaratunga, V Duru, ... Science 347 (6220), 428-431, 2015 | 810 | 2015 |