| Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states AL Sarver, AJ French, PM Borralho, V Thayanithy, AL Oberg, ... BMC cancer 9, 1-15, 2009 | 389 | 2009 |
| miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease RE Castro, DMS Ferreira, MB Afonso, PM Borralho, MV Machado, ... Journal of hepatology 58 (1), 119-125, 2013 | 379 | 2013 |
| Delivering the promise of miRNA cancer therapeutics DM Pereira, PM Rodrigues, PM Borralho, CMP Rodrigues Drug discovery today 18 (5-6), 282-289, 2013 | 348 | 2013 |
| MicroRNA‐143 reduces viability and increases sensitivity to 5‐fluorouracil in HCT116 human colorectal cancer cells PM Borralho, BT Kren, RE Castro, IB Moreira da Silva, CJ Steer, ... The FEBS journal 276 (22), 6689-6700, 2009 | 254 | 2009 |
| miRNA expression in colon polyps provides evidence for a multihit model of colon cancer AL Oberg, AJ French, AL Sarver, S Subramanian, BW Morlan, SM Riska, ... PloS one 6 (6), e20465, 2011 | 186 | 2011 |
| miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice PM Rodrigues, MB Afonso, AL Simão, CC Carvalho, A Trindade, A Duarte, ... Cell death & disease 8 (4), e2748-e2748, 2017 | 131 | 2017 |
| miR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation PM Borralho, AES Simoes, SE Gomes, RT Lima, T Carvalho, ... PloS one 6 (8), e23787, 2011 | 127 | 2011 |
| Efficient recovery of proteins from multiple source samples after trizol® or trizol®LS RNA extraction and long-term storage AES Simões, DM Pereira, JD Amaral, AF Nunes, SE Gomes, ... BMC genomics 14, 1-15, 2013 | 121 | 2013 |
| Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid RE Castro, DMS Ferreira, X Zhang, PM Borralho, AL Sarver, Y Zeng, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 299 (4 …, 2010 | 119 | 2010 |
| KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines J Lavrado, H Brito, PM Borralho, SA Ohnmacht, NS Kim, C Leitão, S Pisco, ... Scientific reports 5 (1), 9696, 2015 | 95 | 2015 |
| Cobalt complexes bearing scorpionate ligands: synthesis, characterization, cytotoxicity and DNA cleavage TFS Silva, LM Martins, MFCG da Silva, AR Fernandes, A Silva, ... Dalton Transactions 41 (41), 12888-12897, 2012 | 95 | 2012 |
| Cyclopentadienyl–ruthenium (II) and iron (II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents PR Florindo, DM Pereira, PM Borralho, CMP Rodrigues, MFM Piedade, ... Journal of Medicinal Chemistry 58 (10), 4339-4347, 2015 | 92 | 2015 |
| Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF‐β1–induced apoptosis in rat hepatocytes S Solá, JD Amaral, RE Castro, RM Ramalho, PM Borralho, BT Kren, ... Hepatology 42 (4), 925-934, 2005 | 92 | 2005 |
| The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target AES Simoes, CMP Rodrigues, PM Borralho Drug discovery today 21 (10), 1654-1663, 2016 | 91 | 2016 |
| c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver DMS Ferreira, MB Afonso, PM Rodrigues, AL Simão, DM Pereira, ... Molecular and cellular biology 34 (6), 1100-1120, 2014 | 88 | 2014 |
| Tauroursodeoxycholic acid modulates p53‐mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells RM Ramalho, PM Borralho, RE Castro, S Solá, CJ Steer, CMP Rodrigues Journal of neurochemistry 98 (5), 1610-1618, 2006 | 86 | 2006 |
| Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53 PM Borralho, IBM da Silva, MM Aranha, C Albuquerque, CN Leitão, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1772 (1), 40-47, 2007 | 71 | 2007 |
| Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid β-peptide-induced apoptosis S Sola, JD Amaral, PM Borralho, RM Ramalho, RE Castro, MM Aranha, ... Molecular endocrinology 20 (10), 2292-2303, 2006 | 70 | 2006 |
| NF‐κB and apoptosis in colorectal tumourigenesis MM Aranha, PM Borralho, P Ravasco, IB Moreira da Silva, L Correia, ... European journal of clinical investigation 37 (5), 416-424, 2007 | 65 | 2007 |
| MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism DM Pereira, AES Simões, SE Gomes, RE Castro, T Carvalho, ... Oncotarget 7 (23), 34322, 2016 | 64 | 2016 |
