| Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment BA Wetmore, JF Wambaugh, SS Ferguson, MA Sochaski, DM Rotroff, ... Toxicological Sciences 125 (1), 157-174, 2012 | 477 | 2012 |
| Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease CD Fisher, AJ Lickteig, LM Augustine, J Ranger-Moore, JP Jackson, ... Drug metabolism and disposition 37 (10), 2087-2094, 2009 | 376 | 2009 |
| Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening DM Rotroff, BA Wetmore, DJ Dix, SS Ferguson, HJ Clewell, KA Houck, ... Toxicological Sciences 117 (2), 348-358, 2010 | 308 | 2010 |
| Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing BA Wetmore, JF Wambaugh, B Allen, SS Ferguson, MA Sochaski, ... Toxicological Sciences 148 (1), 121-136, 2015 | 294 | 2015 |
| Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor Y Chen, SS Ferguson, M Negishi, JA Goldstein Journal of Pharmacology and Experimental Therapeutics 308 (2), 495-501, 2004 | 285 | 2004 |
| Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR … CR Elcombe, RC Peffer, DC Wolf, J Bailey, R Bars, D Bell, RC Cattley, ... Critical reviews in toxicology 44 (1), 64-82, 2014 | 263 | 2014 |
| Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4α SS Ferguson, Y Chen, EL LeCluyse, M Negishi, JA Goldstein Molecular pharmacology 68 (3), 747-757, 2005 | 260 | 2005 |
| A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression H Wang, S Faucette, T Sueyoshi, R Moore, S Ferguson, M Negishi, ... Journal of Biological Chemistry 278 (16), 14146-14152, 2003 | 258 | 2003 |
| In vitro to in vivo extrapolation for high throughput prioritization and decision making SM Bell, X Chang, JF Wambaugh, DG Allen, M Bartels, KLR Brouwer, ... Toxicology in vitro 47, 213-227, 2018 | 233 | 2018 |
| Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro–in vivo correlations NJ Hewitt, EL Lecluyse, SS Ferguson Xenobiotica 37 (10-11), 1196-1224, 2007 | 226 | 2007 |
| Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter Y Chen, SS Ferguson, M Negishi, JA Goldstein Molecular pharmacology 64 (2), 316-324, 2003 | 221 | 2003 |
| Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site SS Ferguson, EL LeCluyse, M Negishi, JA Goldstein Molecular pharmacology 62 (3), 737-746, 2002 | 200 | 2002 |
| Discovery of new potentially defective alleles of human CYP2C9 J Blaisdell, LF Jorge-Nebert, S Coulter, SS Ferguson, SJ Lee, B Chanas, ... Pharmacogenetics and Genomics 14 (8), 527-537, 2004 | 195 | 2004 |
| Identification and functional characterization of new potentially defective alleles of human CYP2C19 J Blaisdell, H Mohrenweiser, J Jackson, S Ferguson, S Coulter, B Chanas, ... Pharmacogenetics and Genomics 12 (9), 703-711, 2002 | 184 | 2002 |
| Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. J Zhang, SS Ferguson, LS Barak, MJ Aber, B Giros, RJ Lefkowitz, ... Receptors & channels 5 (3-4), 193-199, 1997 | 168 | 1997 |
| An intuitive approach for predicting potential human health risk with the Tox21 10k library NS Sipes, JF Wambaugh, R Pearce, SS Auerbach, BA Wetmore, ... Environmental science & technology 51 (18), 10786-10796, 2017 | 161 | 2017 |
| From the cover: Three-dimensional (3D) HepaRG spheroid model with physiologically relevant xenobiotic metabolism competence and hepatocyte functionality for liver toxicity … SC Ramaiahgari, S Waidyanatha, D Dixon, MJ DeVito, RS Paules, ... Toxicological Sciences 159 (1), 124-136, 2017 | 140 | 2017 |
| Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays BA Wetmore, JF Wambaugh, SS Ferguson, L Li, HJ Clewell III, RS Judson, ... toxicological sciences 132 (2), 327-346, 2013 | 140 | 2013 |
| 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration H Wang, PC Brown, ECY Chow, L Ewart, SS Ferguson, S Fitzpatrick, ... Clinical and translational science 14 (5), 1659-1680, 2021 | 132 | 2021 |
| A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes CM Smith, CK Nolan, MA Edwards, JB Hatfield, TW Stewart, SS Ferguson, ... Journal of pharmaceutical sciences 101 (10), 3989-4002, 2012 | 111 | 2012 |