| Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound T Koopmans, TM Wood, P ’t Hart, LHJ Kleijn, APA Hendrickx, RJL Willems, ... Journal of the American Chemical Society 137 (29), 9382-9389, 2015 | 79 | 2015 |
| New insights into nisin’s antibacterial mechanism revealed by binding studies with synthetic lipid II analogues P ‘t Hart, SF Oppedijk, E Breukink, NI Martin Biochemistry 55 (1), 232-237, 2016 | 50 | 2016 |
| Oseltamivir analogues bearing N-substituted guanidines as potent neuraminidase inhibitors CA Mooney, SA Johnson, P ’t Hart, L Quarles van Ufford, CAM de Haan, ... Journal of medicinal chemistry 57 (7), 3154-3160, 2014 | 45 | 2014 |
| N η-substituted arginyl peptide inhibitors of protein arginine N-methyltransferases TM Lakowski, P ’t Hart, CA Ahern, NI Martin, A Frankel ACS Chemical Biology 5 (11), 1053-1063, 2010 | 44 | 2010 |
| Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action LHJ Kleijn, SF Oppedijk, P ’t Hart, RM van Harten, LA Martin-Visscher, ... Journal of medicinal chemistry 59 (7), 3569-3574, 2016 | 42 | 2016 |
| A combined solid-and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics P ´t Hart, LHJ Kleijn, G de Bruin, SF Oppedijk, J Kemmink, NI Martin Organic & Biomolecular Chemistry 12, 913-918, 2013 | 38* | 2013 |
| Peptidic Partial Bisubstrates as Inhibitors of the Protein Arginine N‐Methyltransferases P 't Hart, TM Lakowski, D Thomas, A Frankel, NI Martin ChemBioChem 12 (9), 1427-1432, 2011 | 28 | 2011 |
| Structure based design of bicyclic peptide inhibitors of RbAp48 P ‘t Hart, P Hommen, A Noisier, A Krzyzanowski, D Schüler, AT Porfetye, ... Angewandte Chemie International Edition 60 (4), 1813-1820, 2020 | 27 | 2020 |
| Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5–MEP50 Complex A Krzyzanowski, R Gasper, H Adihou, P 't Hart, H Waldmann ChemBioChem 22 (11), 1908, 2021 | 25 | 2021 |
| Development of Macrocyclic PRMT5–Adaptor Protein Interaction Inhibitors A Krzyzanowski, LM Esser, A Willaume, R Prudent, C Peter, P ‘t Hart, ... Journal of Medicinal Chemistry 65 (22), 15300-15311, 2022 | 18 | 2022 |
| De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria P 't Hart, T Wood, KHME Tehrani, R van Harten, M Śleszyńska, IR Rebollo, ... Chemical Science, Advance Article, 2017 | 15 | 2017 |
| Analogues of the HIV-Tat peptide containing Nη-modified arginines as potent inhibitors of Protein Arginine N-Methyltransferases P 't Hart, D Thomas, R van Ommeren, T Lakowski, A Frankel, N Martin MedChemComm 3, 1235-1244, 2012 | 14 | 2012 |
| Solid‐Phase Peptide Modification via Deaminative Photochemical Csp3‐Csp3 Bond Formation Using Katritzky Salts J Openy, G Amrahova, JY Chang, A Noisier, P Hart Chemistry–A European Journal 28 (39), e202201121, 2022 | 11 | 2022 |
| RNA-binding macrocyclic peptides S Pal, P t Hart Frontiers in Molecular Biosciences, 345, 2022 | 8 | 2022 |
| On-resin photochemical decarboxylative arylation of peptides S Pal, J Openy, A Krzyzanowski, A Noisier, P ‘t Hart Organic Letters 26 (14), 2795-2799, 2023 | 5 | 2023 |
| Rationally designed stapled peptides allosterically inhibit PTBP1–RNA-binding S Schmeing, G Amrahova, K Bigler, JY Chang, J Openy, S Pal, L Posada, ... Chemical Science 14, 8269-8278, 2023 | 5 | 2023 |
| Hot-spot guided design of macrocyclic inhibitors of the LSD1-CoREST1 interaction PT Hart, J Openy, A Krzyzanowski, H Adihou, H Waldmann Tetrahedron 75 (48), 130685, 2019 | 4 | 2019 |
| Weak coupling between magnetically inequivalent spins: The deceptively simple, complicated spectrum of a 13C-labeled trimethylated amine UB le Paige, B Smits, P 't Hart, F Lefeber, NI Martin, H van Ingen Journal of Magnetic Resonance 278, 96-103, 2017 | 3 | 2017 |
| A translational repression reporter assay for the analysis of RNA-binding protein consensus sites J Nowacki, M Malenica, S Schmeing, D Schiller, B Buchmuller, ... RNA biology 20 (1), 85-94, 2023 | 2 | 2023 |
| Challenges in Therapeutically Targeting the RNA‐Recognition Motif S Schmeing, P Hart Wiley Interdisciplinary Reviews: RNA 15 (6), e1877, 2024 | 1 | 2024 |
Nathaniel I. MartinProfessor of Biological Chemistry, Leiden UniversityVerified email at biology.leidenuniv.nl