| Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing Q Pan, O Shai, LJ Lee, BJ Frey, BJ Blencowe Nature genetics 40 (12), 1413-1415, 2008 | 4516 | 2008 |
| The human splicing code reveals new insights into the genetic determinants of disease HY Xiong, B Alipanahi, LJ Lee, H Bretschneider, D Merico, RKC Yuen, ... Science 347 (6218), 1254806, 2015 | 1471 | 2015 |
| The evolutionary landscape of alternative splicing in vertebrate species NL Barbosa-Morais, M Irimia, Q Pan, HY Xiong, S Gueroussov, LJ Lee, ... Science 338 (6114), 1587-1593, 2012 | 1168 | 2012 |
| Deep learning of the tissue-regulated splicing code MKK Leung, HY Xiong, LJ Lee, BJ Frey Bioinformatics 30 (12), i121-i129, 2014 | 627 | 2014 |
| Key parameters of tumor epitope immunogenicity revealed through a consortium approach improve neoantigen prediction DK Wells, MM van Buuren, KK Dang, VM Hubbard-Lucey, KCF Sheehan, ... Cell 183 (3), 818-834. e13, 2020 | 406 | 2020 |
| The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel … T Ohno, M Ouchida, L Lee, Z Gatalica, VN Rao, ES Reddy Oncogene 9 (10), 3087-3097, 1994 | 251 | 1994 |
| Current-generation high-throughput sequencing: deepening insights into mammalian transcriptomes BJ Blencowe, S Ahmad, LJ Lee Genes & development 23 (12), 1379-1386, 2009 | 224 | 2009 |
| TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t (16; 21) chromosomal translocation in human myeloid leukemia functions as a transcriptional … DD Prasad, M Ouchida, L Lee, VN Rao, ES Reddy Oncogene 9 (12), 3717-3729, 1994 | 206 | 1994 |
| Genome-wide analysis of alternative splicing in Caenorhabditis elegans AK Ramani, JA Calarco, Q Pan, S Mavandadi, Y Wang, AC Nelson, ... Genome research 21 (2), 342-348, 2011 | 196 | 2011 |
| Generating and designing DNA with deep generative models N Killoran, LJ Lee, A Delong, D Duvenaud, BJ Frey arXiv preprint arXiv:1712.06148, 2017 | 194 | 2017 |
| BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection RJ Mills, SJ Humphrey, PRJ Fortuna, M Lor, SR Foster, GA Quaife-Ryan, ... Cell 184 (8), 2167-2182. e22, 2021 | 167 | 2021 |
| The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t (12; 22) chromosome translocation, encodes a constitutive transcriptional activator. Y Fujimura, T Ohno, H Siddique, L Lee, VN Rao, ES Reddy Oncogene 12 (1), 159-167, 1996 | 155 | 1996 |
| Functional coordination of alternative splicing in the mammalian central nervous system M Fagnani, Y Barash, JY Ip, C Misquitta, Q Pan, AL Saltzman, O Shai, ... Genome biology 8, 1-17, 2007 | 132 | 2007 |
| Physicians' guideline adherence is associated with long‐term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international … M Komajda, J Schöpe, S Wagenpfeil, L Tavazzi, M Böhm, P Ponikowski, ... European Journal of Heart Failure 21 (7), 921-929, 2019 | 129 | 2019 |
| Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly–capillary malformation syndrome LM McDonell, GM Mirzaa, D Alcantara, J Schwartzentruber, MT Carter, ... Nature genetics 45 (5), 556-562, 2013 | 124 | 2013 |
| Systems and methods for classifying, prioritizing and interpreting genetic variants and therapies using a deep neural network B Frey, MKK Leung, AT Delong, HY Xiong, B Alipanahi, LJ Lee, ... US Patent 10,185,803, 2019 | 109 | 2019 |
| Memory-based graph networks AHK Ahmadi University of Toronto (Canada), 2020 | 108 | 2020 |
| Immunity through swarms: Agent-based simulations of the human immune system C Jacob, J Litorco, L Lee International Conference on Artificial Immune Systems, 400-412, 2004 | 80 | 2004 |
| Characterization of the DNA binding and transcriptional activation domains of the erg protein. HR Siddique, VN Rao, L Lee, ES Reddy Oncogene 8 (7), 1751-1755, 1993 | 74 | 1993 |
| Adaptive Kalman filtering and smoothing for tracking vocal tract resonances using a continuous-valued hidden dynamic model L Deng, LJ Lee, H Attias, A Acero IEEE transactions on audio, speech, and language processing 15 (1), 13-23, 2006 | 68 | 2006 |
Brendan FreyFounder & CEO, Deep Genomics; Co-Founder, Vector Institute; Professor, University of TorontoVerified email at psi.toronto.edu
