| Cellular processing of platinum anticancer drugs D Wang, SJ Lippard Nature reviews Drug discovery 4 (4), 307-320, 2005 | 4488 | 2005 |
| Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis D Wang, DA Bushnell, KD Westover, CD Kaplan, RD Kornberg Cell 127 (5), 941-954, 2006 | 545 | 2006 |
| Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution D Wang, DA Bushnell, X Huang, KD Westover, M Levitt, RD Kornberg Science 324 (5931), 1203-1206, 2009 | 282 | 2009 |
| 5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription MW Kellinger, CX Song, J Chong, XY Lu, C He, D Wang Nature Structural and Molecular Biology 19 (8), 831, 2012 | 270 | 2012 |
| Identification of H3K4me1-associated proteins at mammalian enhancers A Local, H Huang, CP Albuquerque, N Singh, AY Lee, W Wang, C Wang, ... Nature genetics 50 (1), 73-82, 2018 | 255 | 2018 |
| Structure of an RNA polymerase II–TFIIB complex and the transcription initiation mechanism X Liu, DA Bushnell, D Wang, G Calero, RD Kornberg Science 327 (5962), 206-209, 2010 | 239 | 2010 |
| Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro KB Lee, D Wang, SJ Lippard, PA Sharp Proceedings of the National Academy of Sciences 99 (7), 4239-4244, 2002 | 222 | 2002 |
| Clofazimine broadly inhibits coronaviruses including SARS-CoV-2 S Yuan, X Yin, X Meng, JFW Chan, ZW Ye, L Riva, L Pache, CCY Chan, ... Nature 593 (7859), 418-423, 2021 | 196 | 2021 |
| Structural basis for the initiation of eukaryotic transcription-coupled DNA repair J Xu, I Lahiri, W Wang, A Wier, MA Cianfrocco, J Chong, AA Hare, ... Nature 551 (7682), 653-657, 2017 | 192 | 2017 |
| Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex L Wang, Y Zhou, L Xu, R Xiao, X Lu, L Chen, J Chong, H Li, C He, XD Fu, ... Nature 523 (7562), 621-625, 2015 | 173 | 2015 |
| Millisecond dynamics of RNA polymerase II translocation at atomic resolution DA Silva, DR Weiss, F Pardo Avila, LT Da, M Levitt, D Wang, X Huang Proceedings of the National Academy of Sciences 111 (21), 7665-7670, 2014 | 165 | 2014 |
| X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct D Wang, G Zhu, X Huang, SJ Lippard Proceedings of the National Academy of Sciences 107 (21), 9584-9589, 2010 | 138 | 2010 |
| Nucleotide excision repair from site-specifically platinum-modified nucleosomes D Wang, R Hara, G Singh, A Sancar, SJ Lippard Biochemistry 42 (22), 6747-6753, 2003 | 137 | 2003 |
| Dynamics of Pyrophosphate Ion Release and Its Coupled Trigger Loop Motion from Closed to Open State in RNA Polymerase II LT Da, D Wang, X Huang Journal of the American Chemical Society, 2012 | 134 | 2012 |
| RNA sequencing by direct tagmentation of RNA/DNA hybrids L Di, Y Fu, Y Sun, J Li, L Liu, J Yao, G Wang, Y Wu, K Lao, RW Lee, ... Proceedings of the National Academy of Sciences 117 (6), 2886-2893, 2020 | 105 | 2020 |
| Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue LT Da, F Pardo-Avila, L Xu, DA Silva, L Zhang, X Gao, D Wang, X Huang Nature communications 7 (1), 11244, 2016 | 96 | 2016 |
| Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage Y Takagi, CA Masuda, WH Chang, H Komori, D Wang, T Hunter, ... Molecular cell 18 (2), 237-243, 2005 | 86 | 2005 |
| Effect of a monofunctional phenanthriplatin-DNA adduct on RNA polymerase II transcriptional fidelity and translesion synthesis MW Kellinger, GY Park, J Chong, SJ Lippard, D Wang Journal of the American Chemical Society 135 (35), 13054-13061, 2013 | 85 | 2013 |
| RNA polymerase II trigger loop residues stabilize and position the incoming nucleotide triphosphate in transcription X Huang, D Wang, DR Weiss, DA Bushnell, RD Kornberg, M Levitt Proceedings of the National Academy of Sciences 107 (36), 15745-15750, 2010 | 85 | 2010 |
| Cisplatin-induced post-translational modification of histones H3 and H4 D Wang, SJ Lippard Journal of Biological Chemistry 279 (20), 20622-20625, 2004 | 85 | 2004 |
Xuhui HuangHirschfelder Chair in Theoretical Chemistry, University of Wisconsin-Madison (previously at HKUST)Verified email at chem.wisc.edu