Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay DM Molina, R Jafari, M Ignatushchenko, T Seki, EA Larsson, C Dan, ... Science 341 (6141), 84-87, 2013 | 1871 | 2013 |
Ribonucleotide reductases P Nordlund, P Reichard Annu. Rev. Biochem. 75 (1), 681-706, 2006 | 1300 | 2006 |
The cellular thermal shift assay for evaluating drug target interactions in cells R Jafari, H Almqvist, H Axelsson, M Ignatushchenko, T Lundbäck, ... Nature protocols 9 (9), 2100-2122, 2014 | 1214 | 2014 |
Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane AC Rosenzweig, CA Frederick, SJ Lippard, P Nordlund Nature 366 (6455), 537-543, 1993 | 1188 | 1993 |
Thermofluor-based high-throughput stability optimization of proteins for structural studies UB Ericsson, BM Hallberg, GT DeTitta, N Dekker, P Nordlund Analytical biochemistry 357 (2), 289-298, 2006 | 1125 | 2006 |
Three-dimensional structure of the free radical protein of ribonucleotide reductase P Nordlund, BM Sjöberg, H Eklund Nature 345 (6276), 593-598, 1990 | 1121 | 1990 |
Tracking cancer drugs in living cells by thermal profiling of the proteome MM Savitski, FBM Reinhard, H Franken, T Werner, MF Savitski, ... Science 346 (6205), 1255784, 2014 | 1087 | 2014 |
Protein production and purification Architecture et Fonction des Macromolécules Biologiques Vincentelli Renaud 4 ... Nature methods 5 (2), 135-146, 2008 | 1006 | 2008 |
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty Jr, ... Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006 | 743 | 2006 |
Structure and function of the Escherichia coli ribonucleotide reductase protein R2 P Nordlund, H Eklund Journal of Molecular Biology 232 (1), 123-164, 1993 | 622 | 1993 |
Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states AC Rosenzweig, P Nordlund, PM Takahara, CA Frederick, SJ Lippard Chemistry & biology 2 (6), 409-418, 1995 | 531 | 1995 |
Understanding transport by the major facilitator superfamily (MFS): structures pave the way EM Quistgaard, C Löw, F Guettou, P Nordlund Nature Reviews Molecular Cell Biology 17 (2), 123-132, 2016 | 465 | 2016 |
Structure and function of the radical enzyme ribonucleotide reductase H Eklund, U Uhlin, M Färnegårdh, DT Logan, P Nordlund Progress in biophysics and molecular biology 77 (3), 177-268, 2001 | 394 | 2001 |
Crystal structure of human leukotriene A4 hydrolase, a bifunctional enzyme in inflammation MMGM Thunnissen, P Nordlund, JZ Haeggström Nature structural biology 8 (2), 131-135, 2001 | 373 | 2001 |
Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site DT Logan, XD Su, A Åberg, K Regnström, J Hajdu, H Eklund, P Nordlund Structure 4 (9), 1053-1064, 1996 | 330 | 1996 |
Di-iron—carboxylate proteins P Nordlund, H Eklund Current opinion in structural biology 5 (6), 758-766, 1995 | 328 | 1995 |
A saposin-lipoprotein nanoparticle system for membrane proteins J Frauenfeld, R Löving, JP Armache, AFP Sonnen, F Guettou, P Moberg, ... Nature methods 13 (4), 345-351, 2016 | 312 | 2016 |
Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli DE Drew, G Von Heijne, P Nordlund, JWL de Gier FEBS letters 507 (2), 220-224, 2001 | 303 | 2001 |
The cellular thermal shift assay: a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies D Martinez Molina, P Nordlund Annual review of pharmacology and toxicology 56 (1), 141-161, 2016 | 294 | 2016 |
In situ proteolysis for protein crystallization and structure determination A Dong, X Xu, AM Edwards Nature methods 4 (12), 1019-1021, 2007 | 294 | 2007 |