| The tertiary structure and domain organization of coagulation factor VIII BW Shen, PC Spiegel, CH Chang, JW Huh, JS Lee, J Kim, YH Kim, ... Blood, The Journal of the American Society of Hematology 111 (3), 1240-1247, 2008 | 330 | 2008 |
| Observation of intersubunit movement of the ribosome in solution using FRET DN Ermolenko, ZK Majumdar, RP Hickerson, PC Spiegel, RM Clegg, ... Journal of molecular biology 370 (3), 530-540, 2007 | 239 | 2007 |
| A de novo protein binding pair by computational design and directed evolution J Karanicolas, JE Corn, I Chen, LA Joachimiak, O Dym, SH Peck, ... Molecular cell 42 (2), 250-260, 2011 | 199 | 2011 |
| Structure of a factor VIII C2 domain–immunoglobulin G4κ Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII PC Spiegel Jr, M Jacquemin, JMR Saint-Remy, BL Stoddard, KP Pratt Blood, The Journal of the American Society of Hematology 98 (1), 13-19, 2001 | 174 | 2001 |
| The antibiotic viomycin traps the ribosome in an intermediate state of translocation DN Ermolenko, PC Spiegel, ZK Majumdar, RP Hickerson, RM Clegg, ... Nature structural & molecular biology 14 (6), 493-497, 2007 | 170 | 2007 |
| Elongation factor G stabilizes the hybrid-state conformation of the 70S ribosome PC Spiegel, DN Ermolenko, HF Noller Rna 13 (9), 1473-1482, 2007 | 155 | 2007 |
| Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor JM Bolduc, PC Spiegel, P Chatterjee, KL Brady, ME Downing, ... Genes & development 17 (23), 2875-2888, 2003 | 113 | 2003 |
| Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4 JD Walter, M Hunter, M Cobb, G Traeger, PC Spiegel Nucleic acids research 40 (1), 360-370, 2012 | 69 | 2012 |
| Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen–deuterium exchange mass spectrometry AM Sevy, JF Healey, W Deng, PC Spiegel, SL Meeks, R Li Journal of Thrombosis and Haemostasis 11 (12), 2128-2136, 2013 | 48 | 2013 |
| The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold PC Spiegel, B Chevalier, D Sussman, M Turmel, C Lemieux, BL Stoddard Structure 14 (5), 869-880, 2006 | 48 | 2006 |
| Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes JD Walter, RA Werther, CM Brison, RK Cragerud, JF Healey, SL Meeks, ... Blood, The Journal of the American Society of Hematology 122 (26), 4270-4278, 2013 | 46 | 2013 |
| Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities PC Spiegel, P Murphy, BL Stoddard Journal of Biological Chemistry 279 (51), 53691-53698, 2004 | 45 | 2004 |
| Ribosomal protein L7/L12 is required for GTP ase translation factors EF‐G, RF 3, and IF 2 to bind in their GTP state to 70S ribosomes MA Carlson, BG Haddad, AJ Weis, CS Blackwood, CD Shelton, ... The FEBS journal 284 (11), 1631-1643, 2017 | 39 | 2017 |
| Disruption of protein-membrane binding and identification of small-molecule inhibitors of coagulation factor VIII PC Spiegel, SM Kaiser, JA Simon, BL Stoddard Chemistry & biology 11 (10), 1413-1422, 2004 | 37 | 2004 |
| The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain IW Smith, AE d'Aquino, CW Coyle, A Fedanov, ET Parker, G Denning, ... Journal of Thrombosis and Haemostasis 18 (1), 57-69, 2020 | 31 | 2020 |
| Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors? PC Spiegel Jr, BL Stoddard British journal of haematology 119 (2), 2002 | 27 | 2002 |
| Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies JD Walter, RA Werther, MS Polozova, J Pohlman, JF Healey, SL Meeks, ... Journal of Biological Chemistry 288 (14), 9905-9914, 2013 | 25 | 2013 |
| Structure of blood coagulation factor VIII in complex with an anti–C1 domain pathogenic antibody inhibitor JS Gish, L Jarvis, KC Childers, SC Peters, CS Garrels, IW Smith, ... Blood, The Journal of the American Society of Hematology 137 (21), 2981-2986, 2021 | 20 | 2021 |
| Structural insights into blood coagulation factor VIII: Procoagulant complexes, membrane binding, and antibody inhibition KC Childers, SC Peters, PC Spiegel Jr Journal of Thrombosis and Haemostasis 20 (9), 1957-1970, 2022 | 19 | 2022 |
| The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces CM Brison, SM Mullen, ME Wuerth, K Podolsky, M Cook, JA Herman, ... PLoS One 10 (3), e0122447, 2015 | 15 | 2015 |