A cargo-sorting DNA robot AJ Thubagere, W Li, RF Johnson, Z Chen, S Doroudi, YL Lee, G Izatt, ... Science 357 (6356), eaan6558, 2017 | 551 | 2017 |
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity SE Boyken, Z Chen, B Groves, RA Langan, G Oberdorfer, A Ford, ... Science 352 (6286), 680-687, 2016 | 376 | 2016 |
De novo design of bioactive protein switches RA Langan, SE Boyken, AH Ng, JA Samson, G Dods, AM Westbrook, ... Nature 572 (7768), 205-210, 2019 | 277 | 2019 |
De novo design of protein logic gates Z Chen, RD Kibler, A Hunt, F Busch, J Pearl, M Jia, ZL VanAernum, ... Science 368 (6486), 78-84, 2020 | 204 | 2020 |
Programmable design of orthogonal protein heterodimers Z Chen, SE Boyken, M Jia, F Busch, D Flores-Solis, MJ Bick, P Lu, ... Nature 565 (7737), 106-111, 2019 | 194 | 2019 |
Accurate computational design of multipass transmembrane proteins P Lu, D Min, F DiMaio, KY Wei, MD Vahey, SE Boyken, Z Chen, JA Fallas, ... Science 359 (6379), 1042-1046, 2018 | 181 | 2018 |
De novo design of tunable, pH-driven conformational changes SE Boyken, MA Benhaim, F Busch, M Jia, MJ Bick, H Choi, JC Klima, ... Science 364 (6441), 658-664, 2019 | 157 | 2019 |
Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry ZL VanAernum, F Busch, BJ Jones, M Jia, Z Chen, SE Boyken, ... Nature protocols 15 (3), 1132-1157, 2020 | 140 | 2020 |
Programmable protein circuit design Z Chen, MB Elowitz Cell 184 (9), 2284-2301, 2021 | 91 | 2021 |
Self-Assembling 2D Arrays with de Novo Protein Building Blocks Z Chen, MC Johnson, J Chen, MJ Bick, SE Boyken, B Lin, JJ De Yoreo, ... Journal of the American Chemical Society 141 (22), 8891-8895, 2019 | 39 | 2019 |
Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus L Cao, B Yu, D Kong, Q Cong, T Yu, Z Chen, Z Hu, H Chang, J Zhong, ... PLoS pathogens 15 (5), e1007759, 2019 | 31 | 2019 |
Interpreting neural networks for biological sequences by learning stochastic masks J Linder, A La Fleur, Z Chen, A Ljubetič, D Baker, S Kannan, G Seelig Nature machine intelligence 4 (1), 41-54, 2022 | 27 | 2022 |
A synthetic protein-level neural network in mammalian cells Z Chen, JM Linton, R Zhu, MB Elowitz bioRxiv, 2022.07. 10.499405, 2022 | 17 | 2022 |
Modulating mechanical stability of heterodimerization between engineered orthogonal helical domains M Yu, Z Zhao, Z Chen, S Le, J Yan Nature communications 11 (1), 4476, 2020 | 16 | 2020 |
A game-theoretic model of interactions between Hibiscus latent Singapore virus and Tobacco mosaic virus Z Chen, JY Tan, Y Wen, S Niu, SM Wong PLoS One 7 (5), e37007, 2012 | 16 | 2012 |
Rapid online buffer exchange: A method for screening of proteins, protein complexes, and cell lysates by native mass spectrometry Z VanAernum, F Busch, BJ Jones, M Jia, Z Chen, SE Boyken, ... ChemRxiv. org, 2019 | 6 | 2019 |
Competitive Displacement of De Novo Designed HeteroDimers Can Reversibly Control Protein–Protein Interactions and Implement Feedback in Synthetic Circuits TH Nguyen, G Dods, M Gómez-Schiavon, M Wu, Z Chen, R Kibler, ... GEN Biotechnology 1 (1), 91-100, 2022 | 3 | 2022 |
Orthogonal protein heterodimers C Zibo, S Boyken, S Bermeo, RA Langan, D Baker US Patent 11,820,800, 2023 | 1 | 2023 |
Protein circuit design using de novo proteins Z Chen Trends in Biotechnology 41 (5), 593-594, 2023 | 1 | 2023 |
De novo design of phosphorylation inducible protein switches (phospho-switches) N Woodall, S Boyken, MJ Lajoie, C Zibo, RA Langan, D Baker US Patent App. 17/618,117, 2022 | 1 | 2022 |