| Selective inhibition of BET bromodomains P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith, O Fedorov, ... Nature 468 (7327), 1067-1073, 2010 | 4433 | 2010 |
| Histone recognition and large-scale structural analysis of the human bromodomain family P Filippakopoulos, S Picaud, M Mangos, T Keates, JP Lambert, ... Cell 149 (1), 214-231, 2012 | 1800 | 2012 |
| Targeting bromodomains: epigenetic readers of lysine acetylation P Filippakopoulos, S Knapp Nature reviews Drug discovery 13 (5), 337-356, 2014 | 1351 | 2014 |
| Functions of bromodomain-containing proteins and their roles in homeostasis and cancer T Fujisawa, P Filippakopoulos Nature reviews Molecular cell biology 18 (4), 246-262, 2017 | 599 | 2017 |
| Bromodomains as therapeutic targets S Muller, P Filippakopoulos, S Knapp Expert reviews in molecular medicine 13, e29, 2011 | 559 | 2011 |
| Large-scale structural analysis of the classical human protein tyrosine phosphatome AJ Barr, E Ugochukwu, WH Lee, ONF King, P Filippakopoulos, I Alfano, ... Cell 136 (2), 352-363, 2009 | 553 | 2009 |
| Small-molecule inhibition of BRDT for male contraception MM Matzuk, MR McKeown, P Filippakopoulos, Q Li, L Ma, JE Agno, ... Cell 150 (4), 673-684, 2012 | 522 | 2012 |
| RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ... Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013 | 496 | 2013 |
| The bromodomain interaction module P Filippakopoulos, S Knapp FEBS letters 586 (17), 2692-2704, 2012 | 464 | 2012 |
| Dual kinase-bromodomain inhibitors for rationally designed polypharmacology P Ciceri, S Müller, A O'mahony, O Fedorov, P Filippakopoulos, JP Hunt, ... Nature chemical biology 10 (4), 305-312, 2014 | 380 | 2014 |
| Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ... Journal of the American Chemical Society 136 (26), 9308-9319, 2014 | 344 | 2014 |
| PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ... Cancer research 73 (11), 3336-3346, 2013 | 298 | 2013 |
| Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function N Kwiatkowski, N Jelluma, P Filippakopoulos, M Soundararajan, ... Nature chemical biology 6 (5), 359-368, 2010 | 269 | 2010 |
| Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors L Feng, Y Geisselbrecht, S Blanck, A Wilbuer, GE Atilla-Gokcumen, ... Journal of the American Chemical Society 133 (15), 5976-5986, 2011 | 263 | 2011 |
| 3, 5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands DS Hewings, M Wang, M Philpott, O Fedorov, S Uttarkar, ... Journal of medicinal chemistry 54 (19), 6761-6770, 2011 | 259 | 2011 |
| Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit PV Fish, P Filippakopoulos, G Bish, PE Brennan, ME Bunnage, AS Cook, ... Journal of medicinal chemistry 55 (22), 9831-9837, 2012 | 258 | 2012 |
| Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy S Picaud, O Fedorov, A Thanasopoulou, K Leonards, K Jones, J Meier, ... Cancer research 75 (23), 5106-5119, 2015 | 253 | 2015 |
| Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B T Tahtouh, JM Elkins, P Filippakopoulos, M Soundararajan, G Burgy, ... Journal of medicinal chemistry 55 (21), 9312-9330, 2012 | 239 | 2012 |
| Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation P Filippakopoulos, M Kofler, O Hantschel, GD Gish, F Grebien, E Salah, ... Cell 134 (5), 793-803, 2008 | 239 | 2008 |
| Structural analysis identifies imidazo [1, 2-b] pyridazines as PIM kinase inhibitors with in vitro antileukemic activity V Pogacic, AN Bullock, O Fedorov, P Filippakopoulos, C Gasser, A Biondi, ... Cancer research 67 (14), 6916-6924, 2007 | 228 | 2007 |
