| Stapled peptide design: principles and roles of computation YS Tan, DP Lane, CS Verma Drug Discovery Today 21 (10), 1642-1653, 2016 | 137 | 2016 |
| Double strain‐promoted macrocyclization for the rapid selection of cell‐active stapled peptides YH Lau, Y Wu, M Rossmann, BX Tan, P de Andrade, YS Tan, C Verma, ... Angewandte Chemie International Edition 54 (51), 15410-15413, 2015 | 135 | 2015 |
| A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling HSG Beckmann, F Nie, CE Hagerman, H Johansson, YS Tan, D Wilcke, ... Nature Chemistry 5 (10), 861-867, 2013 | 132 | 2013 |
| Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2 M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, ... Scientific Reports 6 (1), 28528, 2016 | 106 | 2016 |
| Diversity-oriented synthesis as a tool for identifying new modulators of mitosis BM Ibbeson, L Laraia, E Alza, CJ O'Connor, YS Tan, HML Davies, ... Nature communications 5 (1), 3155, 2014 | 94 | 2014 |
| Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1 YS Tan, P Śledź, S Lang, CJ Stubbs, DR Spring, C Abell, RB Best Angewandte Chemie (International ed. in English) 51 (40), 10078, 2012 | 93 | 2012 |
| Macrocyclized extended peptides: inhibiting the substrate-recognition domain of tankyrase W Xu, YH Lau, G Fischer, YS Tan, A Chattopadhyay, M de la Roche, ... Journal of the American Chemical Society 139 (6), 2245-2256, 2017 | 74 | 2017 |
| Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide BH Liu, C Jobichen, CSB Chia, THM Chan, JP Tang, TXY Chung, J Li, ... Proceedings of the National Academy of Sciences 115 (30), E7119-E7128, 2018 | 66 | 2018 |
| Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges TK Sawyer, AW Partridge, HYK Kaan, YC Juang, S Lim, C Johannes, ... Bioorganic & Medicinal Chemistry 26 (10), 2807-2815, 2018 | 62 | 2018 |
| Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells BSJ Low, CS Lim, SSL Ding, YS Tan, NHJ Ng, VG Krishnan, SF Ang, ... Nature communications 12 (1), 3133, 2021 | 61 | 2021 |
| Incorporation of putative helix-breaking amino acids in the design of novel stapled peptides: Exploring biophysical and cellular permeability properties AW Partridge, HYK Kaan, YC Juang, A Sadruddin, S Lim, CJ Brown, S Ng, ... Molecules 24 (12), 2292, 2019 | 56 | 2019 |
| Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, ... Angewandte Chemie International Edition 56 (2), 524-529, 2017 | 54 | 2017 |
| Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity S Zheng, L Laraia, CJ O'Connor, D Sorrell, YS Tan, Z Xu, ... Organic & Biomolecular Chemistry 10 (13), 2590-2593, 2012 | 54 | 2012 |
| The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans CR Coffill, AP Lee, JW Siau, SM Chee, TL Joseph, YS Tan, ... Genes & development 30 (3), 281-292, 2016 | 47 | 2016 |
| Benzene probes in molecular dynamics simulations reveal novel binding sites for ligand design YS Tan, J Reeks, CJ Brown, D Thean, FJ Ferrer Gago, TY Yuen, ETL Goh, ... The Journal of Physical Chemistry Letters 7 (17), 3452-3457, 2016 | 46 | 2016 |
| Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell A Chattopadhyay, CJ O’Connor, F Zhang, C Galvagnion, WRJD Galloway, ... Scientific reports 6 (1), 23732, 2016 | 45 | 2016 |
| A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds A Isidro-Llobet, KH Georgiou, WRJD Galloway, E Giacomini, MR Hansen, ... Organic & Biomolecular Chemistry 13 (15), 4570-4580, 2015 | 44 | 2015 |
| The use of chlorobenzene as a probe molecule in molecular dynamics simulations YS Tan, DR Spring, C Abell, C Verma Journal of chemical information and modeling 54 (7), 1821-1827, 2014 | 44 | 2014 |
| Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability S Kannan, PGA Aronica, S Ng, DTG Lian, Y Frosi, S Chee, J Shimin, ... Chemical Science 11 (21), 5577-5591, 2020 | 42 | 2020 |
| Stapled peptides as a new technology to investigate protein–protein interactions in human platelets J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ... Chemical Science 9 (20), 4638-4643, 2018 | 42 | 2018 |
Chandra VermaBioinformatics InstituteVerified email at bii.a-star.edu.sg
