Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease R Sherrington, EI Rogaev, Y Liang, EA Rogaeva, G Levesque, M Ikeda, ... Nature 375 (6534), 754-760, 1995 | 5608 | 1995 |
Drug repurposing: progress, challenges and recommendations S Pushpakom, F Iorio, PA Eyers, KJ Escott, S Hopper, A Wells, A Doig, ... Nature reviews Drug discovery 18 (1), 41-58, 2019 | 3976 | 2019 |
The support of human genetic evidence for approved drug indications MR Nelson, H Tipney, JL Painter, J Shen, P Nicoletti, Y Shen, A Floratos, ... Nature genetics 47 (8), 856-860, 2015 | 1466 | 2015 |
Open Targets: a platform for therapeutic target identification and validation G Koscielny, P An, D Carvalho-Silva, JA Cham, L Fumis, R Gasparyan, ... Nucleic acids research 45 (D1), D985-D994, 2017 | 483 | 2017 |
Use of genome-wide association studies for drug repositioning P Sanseau, P Agarwal, MR Barnes, T Pastinen, JB Richards, LR Cardon, ... Nature biotechnology 30 (4), 317-320, 2012 | 432 | 2012 |
Computational drug repositioning: from data to therapeutics MR Hurle, L Yang, Q Xie, DK Rajpal, P Sanseau, P Agarwal Clinical Pharmacology & Therapeutics 93 (4), 335-341, 2013 | 414 | 2013 |
Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2 NS Delany, M Hurle, P Facer, T Alnadaf, C Plumpton, IAN Kinghorn, ... Physiological genomics, 2001 | 292 | 2001 |
Two simple procedures for releasing chromatin from routinely fixed cells for fluorescence in situ hybridization H Fidlerova, G Senger, M Kost, P Sanseau, D Sheer Cytogenetic and Genome Research 65 (3), 203-205, 1994 | 176 | 1994 |
Evolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugs JR Brown, KK Koretke, ML Birkeland, P Sanseau, DR Patrick BMC Evolutionary Biology 4, 1-10, 2004 | 158 | 2004 |
A computational view of microRNAs and their targets JR Brown, P Sanseau Drug Discovery Today 10 (8), 595-601, 2005 | 151 | 2005 |
Rapid in silico cloning of genes using expressed sequence tags (ESTs) RW Gill, P Sanseau Elsevier 5, 25-44, 2000 | 135 | 2000 |
Cloning of STK13, a Third Human Protein Kinase Related toDrosophilaAurora and Budding Yeast Ipl1 That Maps on Chromosome 19q13. 3–ter M Bernard, P Sanseau, C Henry, A Couturier, C Prigent Genomics 53 (3), 406-409, 1998 | 125 | 1998 |
In silico prediction of novel therapeutic targets using gene–disease association data E Ferrero, I Dunham, P Sanseau Journal of translational medicine 15, 1-16, 2017 | 124 | 2017 |
Rational drug repositioning by medical genetics ZY Wang, HY Zhang Nature biotechnology 31 (12), 1080-1082, 2013 | 111 | 2013 |
Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24. 3) associated with familial Alzheimer disease (AD3 locus) MK Trower, SM Orton, IJ Purvis, P Sanseau, J Riley, C Christodoulou, ... Proceedings of the National Academy of Sciences 93 (4), 1366-1369, 1996 | 99 | 1996 |
Evolutionary dynamics of non-coding sequences within the class II region of the human MHC S Beck, S Abdulla, RP Alderton, RJ Glynne, IG Gut, LK Hosking, ... Journal of molecular biology 255 (1), 1-13, 1996 | 97 | 1996 |
The role of positive selection in determining the molecular cause of species differences in disease JJ Vamathevan, S Hasan, RD Emes, H Amrine-Madsen, D Rajagopalan, ... BMC Evolutionary Biology 8, 1-14, 2008 | 91 | 2008 |
Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development JJ Vamathevan, MD Hall, S Hasan, PM Woollard, M Xu, Y Yang, X Li, ... Toxicology and applied pharmacology 270 (2), 149-157, 2013 | 72 | 2013 |
Released chromatin: linearized DNA for high resolution fluorescence in situ hybridization G Senger, T A. Jones, H Fldlerová, P Sanséau, J Trowsdale, M Duff, ... Human molecular genetics 3 (8), 1275-1280, 1994 | 72 | 1994 |
Systematic prediction of drug combinations based on clinical side-effects H Huang, P Zhang, XA Qu, P Sanseau, L Yang Scientific reports 4 (1), 7160, 2014 | 69 | 2014 |