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Stephen Thorpe
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The response of bone marrow-derived mesenchymal stem cells to dynamic compression following TGF-β3 induced chondrogenic differentiation
SD Thorpe, CT Buckley, T Vinardell, FJ O’Brien, VA Campbell, DJ Kelly
Annals of biomedical engineering 38 (9), 2896-2909, 2010
2482010
Biophysical regulation of chromatin architecture instills a mechanical memory in mesenchymal stem cells
SJ Heo, SD Thorpe, TP Driscoll, RL Duncan, DA Lee, RL Mauck
Scientific reports 5 (1), 16895, 2015
2022015
Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity
SJ Heo, TP Driscoll, SD Thorpe, NL Nerurkar, BM Baker, MT Yang, ...
Elife 5, e18207, 2016
1852016
The effect of concentration, thermal history and cell seeding density on the initial mechanical properties of agarose hydrogels
CT Buckley, SD Thorpe, FJ O’Brien, AJ Robinson, DJ Kelly
Journal of the mechanical behavior of biomedical materials 2 (5), 512-521, 2009
1762009
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells
SD Thorpe, CT Buckley, T Vinardell, FJ O’Brien, VA Campbell, DJ Kelly
Biochemical and biophysical research communications 377 (2), 458-462, 2008
1512008
Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells
G Pattappa, SD Thorpe, NC Jegard, HK Heywood, JD de Bruijn, DA Lee
Tissue Engineering Part C: Methods 19 (1), 68-79, 2013
1392013
Functional properties of cartilaginous tissues engineered from infrapatellar fat pad-derived mesenchymal stem cells
CT Buckley, T Vinardell, SD Thorpe, MG Haugh, E Jones, D McGonagle, ...
Journal of biomechanics 43 (5), 920-926, 2010
1392010
Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression
EG Meyer, CT Buckley, SD Thorpe, DJ Kelly
Journal of biomechanics 43 (13), 2516-2523, 2010
1212010
Mechanical stimulation: a crucial element of organ-on-chip models
CL Thompson, S Fu, HK Heywood, MM Knight, SD Thorpe
Frontiers in bioengineering and biotechnology 8, 602646, 2020
1182020
Cell–matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure
AJ Steward, SD Thorpe, T Vinardell, CT Buckley, DR Wagner, DJ Kelly
Acta Biomaterialia 8 (6), 2153-2159, 2012
1062012
Chondrogenesis and Integration of Mesenchymal Stem Cells Within an In Vitro Cartilage Defect Repair Model
T Vinardell, SD Thorpe, CT Buckley, DJ Kelly
Annals of biomedical engineering 37, 2556-2565, 2009
972009
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway
A Chronopoulos, SD Thorpe, E Cortes, D Lachowski, AJ Rice, ...
Nature materials 19 (6), 669-678, 2020
952020
Modulating gradients in regulatory signals within mesenchymal stem cell seeded hydrogels: a novel strategy to engineer zonal articular cartilage
SD Thorpe, T Nagel, SF Carroll, DJ Kelly
PLoS One 8 (4), e60764, 2013
892013
Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival
E Cortes, D Lachowski, B Robinson, M Sarper, JS Teppo, SD Thorpe, ...
EMBO reports 20 (1), e46557, 2019
842019
Adipogenic differentiation of hMSCs is mediated by recruitment of IGF‐1r onto the primary cilium associated with cilia elongation
MT Dalbay, SD Thorpe, JT Connelly, JP Chapple, MM Knight
Stem Cells 33 (6), 1952-1961, 2015
782015
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment
E Cortes, M Sarper, B Robinson, D Lachowski, A Chronopoulos, ...
EMBO reports 20 (1), e46556, 2019
762019
Temporal and spatial changes in cartilage-matrix-specific gene expression in mesenchymal stem cells in response to dynamic compression
MG Haugh, EG Meyer, SD Thorpe, T Vinardell, GP Duffy, DJ Kelly
Tissue Engineering Part A 17 (23-24), 3085-3093, 2011
762011
Retinoic acid receptor‐β is downregulated in hepatocellular carcinoma and cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells
E Cortes, D Lachowski, A Rice, A Chronopoulos, B Robinson, S Thorpe, ...
Hepatology 69 (2), 785-802, 2019
67*2019
Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration
K Sliogeryte, SD Thorpe, Z Wang, CL Thompson, N Gavara, MM Knight
Journal of Biomechanics 49 (2), 310-317, 2016
652016
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor
E Cortes, D Lachowski, A Rice, SD Thorpe, B Robinson, G Yeldag, ...
Oncogene 38 (16), 2910-2922, 2019
622019
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