| Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase SI Imai, CM Armstrong, M Kaeberlein, L Guarente Nature 403 (6771), 795-800, 2000 | 4285 | 2000 |
| hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase H Vaziri, SK Dessain, EN Eaton, SI Imai, RA Frye, TK Pandita, L Guarente, ... Cell 107 (2), 149-159, 2001 | 3405 | 2001 |
| Negative control of p53 by Sir2α promotes cell survival under stress J Luo, AY Nikolaev, S Imai, D Chen, F Su, A Shiloh, L Guarente, W Gu Cell 107 (2), 137-148, 2001 | 2714 | 2001 |
| Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice J Yoshino, KF Mills, MJ Yoon, S Imai Cell metabolism 14 (4), 528-536, 2011 | 1446 | 2011 |
| NAD+ and sirtuins in aging and disease S Imai, L Guarente Trends in cell biology 24 (8), 464-471, 2014 | 1354 | 2014 |
| Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis KM Ramsey, J Yoshino, CS Brace, D Abrassart, Y Kobayashi, B Marcheva, ... Science 324 (5927), 651-654, 2009 | 1289 | 2009 |
| Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme JR Revollo, A Körner, KF Mills, A Satoh, T Wang, A Garten, B Dasgupta, ... Cell metabolism 6 (5), 363-375, 2007 | 1223 | 2007 |
| The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells JR Revollo, AA Grimm, S Imai Journal of Biological Chemistry 279 (49), 50754-50763, 2004 | 1223 | 2004 |
| NAD+ intermediates: the biology and therapeutic potential of NMN and NR J Yoshino, JA Baur, S Imai Cell metabolism 27 (3), 513-528, 2018 | 851 | 2018 |
| Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice KF Mills, S Yoshida, LR Stein, A Grozio, S Kubota, Y Sasaki, P Redpath, ... Cell metabolism 24 (6), 795-806, 2016 | 818 | 2016 |
| Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice KA Moynihan, AA Grimm, MM Plueger, E Bernal-Mizrachi, E Ford, ... Cell metabolism 2 (2), 105-117, 2005 | 813 | 2005 |
| Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH A Satoh, CS Brace, N Rensing, P Cliften, DF Wozniak, ED Herzog, ... Cell metabolism 18 (3), 416-430, 2013 | 804 | 2013 |
| The dynamic regulation of NAD metabolism in mitochondria LR Stein, S Imai Trends in Endocrinology & Metabolism 23 (9), 420-428, 2012 | 609 | 2012 |
| Nampt: linking NAD biology, metabolism and cancer A Garten, S Petzold, A Körner, S Imai, W Kiess Trends in endocrinology & metabolism 20 (3), 130-138, 2009 | 522 | 2009 |
| Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases S Imai, L Guarente Trends in pharmacological sciences 31 (5), 212-220, 2010 | 496 | 2010 |
| Poly (ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2α deacetylase activity JB Pillai, A Isbatan, S Imai, MP Gupta Journal of Biological Chemistry 280 (52), 43121-43130, 2005 | 488 | 2005 |
| Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance J Yoshino, C Conte, L Fontana, B Mittendorfer, S Imai, KB Schechtman, ... Cell metabolism 16 (5), 658-664, 2012 | 440 | 2012 |
| The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals JR Revollo, AA Grimm, S Imai Current opinion in gastroenterology 23 (2), 164-170, 2007 | 412 | 2007 |
| Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice NE de Picciotto, LB Gano, LC Johnson, CR Martens, AL Sindler, KF Mills, ... Aging cell 15 (3), 522-530, 2016 | 392 | 2016 |
| It takes two to tango: NAD+ and sirtuins in aging/longevity control S Imai, L Guarente npj Aging and Mechanisms of Disease 2 (1), 1-6, 2016 | 376 | 2016 |
