| Genomically recoded organisms expand biological functions MJ Lajoie, AJ Rovner, DB Goodman, HR Aerni, AD Haimovich, ... science 342 (6156), 357-360, 2013 | 981 | 2013 |
| Precise manipulation of chromosomes in vivo enables genome-wide codon replacement FJ Isaacs, PA Carr, HH Wang, MJ Lajoie, B Sterling, L Kraal, AC Tolonen, ... Science 333 (6040), 348-353, 2011 | 683 | 2011 |
| Causes and effects of N-terminal codon bias in bacterial genes DB Goodman, GM Church, S Kosuri Science 342 (6157), 475-479, 2013 | 639 | 2013 |
| Composability of regulatory sequences controlling transcription and translation in Escherichia coli S Kosuri, DB Goodman, G Cambray, VK Mutalik, Y Gao, AP Arkin, D Endy, ... Proceedings of the National Academy of Sciences 110 (34), 14024-14029, 2013 | 491 | 2013 |
| Design, synthesis, and testing toward a 57-codon genome. N Ostrov, M Landon, M Guell, G Kuznetsov, J Teramoto, N Cervantes, ... Science 353 (6301), 819–822, 2016 | 370 | 2016 |
| Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency DN Nguyen, TL Roth, PJ Li, PA Chen, R Apathy, MR Mamedov, LT Vo, ... Nature biotechnology 38 (1), 44-49, 2020 | 264 | 2020 |
| Pooled knockin targeting for genome engineering of cellular immunotherapies TL Roth, PJ Li, F Blaeschke, JF Nies, R Apathy, C Mowery, R Yu, ... Cell 181 (3), 728-744. e21, 2020 | 183 | 2020 |
| Evolutionary constraint and innovation across hundreds of placental mammals MJ Christmas, IM Kaplow, DP Genereux, MX Dong, GM Hughes, X Li, ... Science 380 (6643), eabn3943, 2023 | 133 | 2023 |
| Comparative proteogenomics: combining mass spectrometry and comparative genomics to analyze multiple genomes N Gupta, J Benhamida, V Bhargava, D Goodman, E Kain, I Kerman, ... Genome research 18 (7), 1133-1142, 2008 | 131 | 2008 |
| A multiplexed assay for exon recognition reveals that an unappreciated fraction of rare genetic variants cause large-effect splicing disruptions R Chong, KD Insigne, D Yao, CP Burghard, J Wang, YHE Hsiao, ... Molecular cell 73 (1), 183-194. e8, 2019 | 124 | 2019 |
| Engineering and optimising deaminase fusions for genome editing L Yang, AW Briggs, WL Chew, P Mali, M Guell, J Aach, DB Goodman, ... Nature communications 7 (1), 13330, 2016 | 108 | 2016 |
| High-throughput functional variant screens via in vivo production of single-stranded DNA MG Schubert, DB Goodman, TM Wannier, D Kaur, F Farzadfard, TK Lu, ... Proceedings of the National Academy of Sciences 118 (18), e2018181118, 2021 | 94 | 2021 |
| Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli MG Napolitano, M Landon, CJ Gregg, MJ Lajoie, L Govindarajan, ... Proceedings of the National Academy of Sciences 113 (38), E5588-E5597, 2016 | 76 | 2016 |
| DNAplotlib: programmable visualization of genetic designs and associated data BS Der, E Glassey, BA Bartley, C Enghuus, DB Goodman, DB Gordon, ... ACS synthetic biology 6 (7), 1115-1119, 2017 | 61 | 2017 |
| Rational optimization of tolC as a powerful dual selectable marker for genome engineering CJ Gregg, MJ Lajoie, MG Napolitano, JA Mosberg, DB Goodman, J Aach, ... Nucleic acids research 42 (7), 4779-4790, 2014 | 61 | 2014 |
| Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies DB Goodman, CS Azimi, K Kearns, A Talbot, K Garakani, J Garcia, ... Science translational medicine 14 (670), eabm1463, 2022 | 56 | 2022 |
| Optimizing complex phenotypes through model-guided multiplex genome engineering G Kuznetsov, DB Goodman, GT Filsinger, M Landon, N Rohland, J Aach, ... Genome biology 18, 1-12, 2017 | 39 | 2017 |
| Modular pooled discovery of synthetic knockin sequences to program durable cell therapies F Blaeschke, YY Chen, R Apathy, B Daniel, AY Chen, PA Chen, K Sandor, ... Cell 186 (19), 4216-4234. e33, 2023 | 26 | 2023 |
| Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel I Tiemann-Boege, C Curtis, DN Shinde, DB Goodman, S Tavare, ... Analytical chemistry 81 (14), 5770-5776, 2009 | 23 | 2009 |
| Naturally occurring T cell mutations enhance engineered T cell therapies J Garcia, J Daniels, Y Lee, I Zhu, K Cheng, Q Liu, D Goodman, C Burnett, ... Nature 626 (7999), 626-634, 2024 | 22 | 2024 |
George ChurchHarvard Medical SchoolBestätigte E-Mail-Adresse bei harvard.edu
