Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene HWD Matthes, R Maldonado, F Simonin, O Valverde, S Slowe, I Kitchen, ... Nature 383 (6603), 819-823, 1996 | 2139 | 1996 |
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB1 Receptor Knockout Mice C Ledent, O Valverde, G Cossu, F Petitet, JF Aubert, F Beslot, GA Bohme, ... Science 283 (5400), 401-404, 1999 | 1538 | 1999 |
Mice deficient for δ-and μ-opioid receptors exhibit opposing alterations of emotional responses D Filliol, S Ghozland, J Chluba, M Martin, HWD Matthes, F Simonin, ... Nature genetics 25 (2), 195-200, 2000 | 801 | 2000 |
Involvement of the endocannabinoid system in drug addiction R Maldonado, O Valverde, F Berrendero Trends in neurosciences 29 (4), 225-232, 2006 | 701 | 2006 |
Involvement of CB1 cannabinoid receptors in emotional behaviour M Martin, C Ledent, M Parmentier, R Maldonado, O Valverde Psychopharmacology 159, 379-387, 2002 | 610 | 2002 |
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors R Maldonado, A Saiardi, O Valverde, TA Samad, BP Roques, E Borrelli Nature 388 (6642), 586-589, 1997 | 599 | 1997 |
Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory C Mazzucchelli, C Vantaggiato, A Ciamei, S Fasano, P Pakhotin, ... Neuron 34 (5), 807-820, 2002 | 584 | 2002 |
Disruption of the κ-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U-50,488 H and … F Simonin, O Valverde, C Smadja, S Slowe, I Kitchen, A Dierich, ... The EMBO journal 17 (4), 886-897, 1998 | 511 | 1998 |
Functional interaction between opioid and cannabinoid receptors in drug self-administration M Navarro, MRA Carrera, W Fratta, O Valverde, G Cossu, L Fattore, ... Journal of Neuroscience 21 (14), 5344-5350, 2001 | 438 | 2001 |
Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence A Castañé, E Valjent, C Ledent, M Parmentier, R Maldonado, O Valverde Neuropharmacology 43 (5), 857-867, 2002 | 286 | 2002 |
Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice M Martin, C Ledent, M Parmentier, R Maldonado, O Valverde European Journal of Neuroscience 12 (11), 4038-4046, 2000 | 283 | 2000 |
Activity of the δ-opioid receptor is partially reduced, whereas activity of the κ-receptor is maintained in mice lacking the μ-receptor HWD Matthes, C Smadja, O Valverde, JL Vonesch, AS Foutz, E Boudinot, ... Journal of Neuroscience 18 (18), 7285-7295, 1998 | 252 | 1998 |
Lack of CB1 cannabinoid receptor impairs cocaine self-administration G Soria, V Mendizábal, C Touriño, P Robledo, C Ledent, M Parmentier, ... Neuropsychopharmacology 30 (9), 1670-1680, 2005 | 246 | 2005 |
Δ9‐tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding … O Valverde, F Noble, F Beslot, V Daugé, MC Fournié‐Zaluski, BP Roques European Journal of Neuroscience 13 (9), 1816-1824, 2001 | 242* | 2001 |
BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice E Aso, A Ozaita, EM Valdizán, C Ledent, Á Pazos, R Maldonado, ... Journal of neurochemistry 105 (2), 565-572, 2008 | 227 | 2008 |
Age‐related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour M Maccarrone, O Valverde, ML Barbaccia, A Castañé, R Maldonado, ... European journal of neuroscience 15 (7), 1178-1186, 2002 | 195 | 2002 |
Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors A Bilkei-Gorzo, I Racz, O Valverde, M Otto, K Michel, M Sarstre, A Zimmer Proceedings of the National Academy of Sciences 102 (43), 15670-15675, 2005 | 185 | 2005 |
Absence of Δ-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice A Zimmer, E Valjent, M König, AM Zimmer, P Robledo, H Hahn, ... Journal of Neuroscience 21 (23), 9499-9505, 2001 | 169 | 2001 |
Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice I Gracia-Rubio, M Moscoso-Castro, OJ Pozo, J Marcos, R Nadal, ... Progress in Neuro-Psychopharmacology and Biological Psychiatry 65, 104-117, 2016 | 160 | 2016 |
CB1 receptor-deficient mice as a model for depression O Valverde, M Torrens Neuroscience 204, 193-206, 2012 | 155 | 2012 |