Assessing computational tools for the discovery of transcription factor binding sites M Tompa, N Li, TL Bailey, GM Church, B De Moor, E Eskin, AV Favorov, ... Nature Biotechnology 23 (1), 137, 2005 | 1620 | 2005 |
Multiplexed droplet single-cell RNA-sequencing using natural genetic variation HM Kang, M Subramaniam, S Targ, M Nguyen, L Maliskova, E McCarthy, ... Nature Biotechnology 36 (1), 89, 2018 | 929 | 2018 |
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins K Schumann, S Lin, E Boyer, DR Simeonov, M Subramaniam, RE Gate, ... Proceedings of the National Academy of Sciences 112 (33), 10437-10442, 2015 | 850 | 2015 |
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells LJ Rupp, K Schumann, KT Roybal, RE Gate, CJ Ye, WA Lim, A Marson Scientific Reports 7 (1), 737, 2017 | 746 | 2017 |
EmptyDrops: distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data ATL Lun, S Riesenfeld, T Andrews, T Gomes, JC Marioni Genome Biology 20 (1), 63, 2019 | 725 | 2019 |
Intratumoral CD4+ T cells mediate anti-tumor cytotoxicity in human bladder cancer DY Oh, SS Kwek, SS Raju, T Li, E McCarthy, E Chow, D Aran, A Ilano, ... Cell 181 (7), 1612-1625. e13, 2020 | 565 | 2020 |
Unleashing type-2 dendritic cells to drive protective antitumor CD4+ T cell immunity M Binnewies, AM Mujal, JL Pollack, AJ Combes, EA Hardison, KC Barry, ... Cell 177 (3), 556-571. e16, 2019 | 560 | 2019 |
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes T Raj, K Rothamel, S Mostafavi, C Ye, MN Lee, JM Replogle, T Feng, ... Science 344 (6183), 519-523, 2014 | 548 | 2014 |
A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks O Parnas, M Jovanovic, TM Eisenhaure, RH Herbst, A Dixit, CJ Ye, ... Cell 162 (3), 675-686, 2015 | 536 | 2015 |
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance JD Whitman, J Hiatt, CT Mowery, BR Shy, R Yu, TN Yamamoto, U Rathore, ... Nature Biotechnology, 1-10, 2020 | 513* | 2020 |
Common genetic variants modulate pathogen-sensing responses in human dendritic cells MN Lee, C Ye, AC Villani, T Raj, W Li, TM Eisenhaure, SH Imboywa, ... Science 343 (6175), 1246980, 2014 | 494 | 2014 |
Single-cell RNA sequencing of lymph node stromal cells reveals niche-associated heterogeneity LB Rodda, E Lu, ML Bennett, CL Sokol, X Wang, SA Luther, BA Barres, ... Immunity 48 (5), 1014-1028. e6, 2018 | 392 | 2018 |
Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing A Kirby, A Gnirke, DB Jaffe, V Barešová, N Pochet, B Blumenstiel, C Ye, ... Nature Genetics 45 (3), 299, 2013 | 318 | 2013 |
Parsing the interferon transcriptional network and its disease associations S Mostafavi, H Yoshida, D Moodley, H LeBoité, K Rothamel, T Raj, CJ Ye, ... Cell 164 (3), 564-578, 2016 | 307 | 2016 |
Discovery of stimulation-responsive immune enhancers with CRISPR activation DR Simeonov, BG Gowen, M Boontanrart, TL Roth, JD Gagnon, ... Nature 549 (7670), 111, 2017 | 305 | 2017 |
Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease S Yazar, J Alquicira-Hernandez, K Wing, A Senabouth, MG Gordon, ... Science 376 (6589), eabf3041, 2022 | 304 | 2022 |
Transethnic genetic-correlation estimates from summary statistics BC Brown, CJ Ye, AL Price, N Zaitlen The American Journal of Human Genetics 99 (1), 76-88, 2016 | 283 | 2016 |
Intersection of population variation and autoimmunity genetics in human T cell activation CJ Ye, T Feng, HK Kwon, T Raj, MT Wilson, N Asinovski, C McCabe, ... Science 345 (6202), 1254665, 2014 | 268 | 2014 |
Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupus RK Perez, MG Gordon, M Subramaniam, MC Kim, GC Hartoularos, S Targ, ... Science 376 (6589), eabf1970, 2022 | 266 | 2022 |
Global absence and targeting of protective immune states in severe COVID-19 AJ Combes, T Courau, NF Kuhn, KH Hu, A Ray, WS Chen, NW Chew, ... Nature 591 (7848), 124-130, 2021 | 258 | 2021 |