| Synthesis and evaluation of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors TO Olomola, R Klein, N Mautsa, Y Sayed, PT Kaye Bioorganic & medicinal chemistry 21 (7), 1964-1971, 2013 | 124 | 2013 |
| Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors TO Olomola, R Klein, KA Lobb, Y Sayed, PT Kaye Tetrahedron Letters 51 (48), 6325-6328, 2010 | 80 | 2010 |
| The hydrophobic lock-and-key intersubunit motif of glutathione transferase A1-1: implications for catalysis, ligandin function and stability Y Sayed, LA Wallace, HW Dirr FEBS letters 465 (2-3), 169-172, 2000 | 80 | 2000 |
| Protease inhibition in African subtypes of HIV-1 A Velázquez-Campoy, S Vega, E Fleming, U Bacha, Y Sayed, HW Dirr, ... Aids Rev 5 (3), 165-171, 2003 | 65 | 2003 |
| Thermodynamics of the ligandin function of human class Alpha glutathione transferase A1-1: energetics of organic anion ligand binding Y Sayed, JAT Hornby, M Lopez, H Dirr Biochemical Journal 363 (2), 341-346, 2002 | 52 | 2002 |
| Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance P Naicker, I Achilonu, S Fanucchi, M Fernandes, MAA Ibrahim, HW Dirr, ... Journal of Biomolecular Structure and Dynamics 31 (12), 1370-1380, 2013 | 50 | 2013 |
| Active-site mutations in the South African human immunodeficiency virus type 1 subtype C protease have a significant impact on clinical inhibitor binding: kinetic and … S Mosebi, L Morris, HW Dirr, Y Sayed Journal of virology 82 (22), 11476-11479, 2008 | 50 | 2008 |
| Comparison of the molecular dynamics and calculated binding free energies for nine FDA‐approved HIV‐1 PR drugs against subtype B and C‐SA HIV PR SM Ahmed, HG Kruger, T Govender, GEM Maguire, Y Sayed, ... Chemical biology & drug design 81 (2), 208-218, 2013 | 48 | 2013 |
| Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: A hybrid 2D NMR and docking/QM/MM/MD approach MM Makatini, K Petzold, SN Sriharsha, N Ndlovu, MES Soliman, ... European journal of medicinal chemistry 46 (9), 3976-3985, 2011 | 48 | 2011 |
| Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease MM Makatini, K Petzold, SN Sriharsha, MES Soliman, B Honarparvar, ... Bioorganic & medicinal chemistry letters 21 (8), 2274-2277, 2011 | 46 | 2011 |
| Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study DC Kuhnert, Y Sayed, S Mosebi, M Sayed, T Sewell, HW Dirr Journal of molecular biology 349 (4), 825-838, 2005 | 43 | 2005 |
| Characterization of bromosulphophthalein binding to human glutathione S-transferase A1-1: thermodynamics and inhibition kinetics D Kolobe, Y Sayed, HW Dirr Biochemical Journal 382 (2), 703-709, 2004 | 41 | 2004 |
| A conserved N-capping motif contributes significantly to the stabilization and dynamics of the C-terminal region of class Alpha glutathione S-transferases HW Dirr, T Little, DC Kuhnert, Y Sayed Journal of biological chemistry 280 (20), 19480-19487, 2005 | 37 | 2005 |
| Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies SB Maseko, S Natarajan, V Sharma, N Bhattacharyya, T Govender, ... Protein expression and purification 122, 90-96, 2016 | 33 | 2016 |
| V2-directed vaccine-like antibodies from HIV-1 infection identify an additional K169-binding light chain motif with broad ADCC activity C van Eeden, CK Wibmer, C Scheepers, SI Richardson, M Nonyane, ... Cell reports 25 (11), 3123-3135. e6, 2018 | 32 | 2018 |
| Binding free energy calculations of nine FDA‐approved protease inhibitors against HIV‐1 subtype C I36T↑ T containing 100 amino acids per monomer HA Lockhat, JRA Silva, CN Alves, T Govender, J Lameira, GEM Maguire, ... Chemical biology & drug design 87 (4), 487-498, 2016 | 32 | 2016 |
| Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors R Karpoormath, Y Sayed, P Govender, T Govender, HG Kruger, ... Bioorganic chemistry 40, 19-29, 2012 | 32 | 2012 |
| The intersubunit lock-and-key motif in human glutathione transferase A1-1: role of the key residues Met51 and Phe52 in function and dimer stability CS Alves, DC Kuhnert, Y Sayed, HW Dirr Biochemical journal 393 (2), 523-528, 2006 | 31 | 2006 |
| Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions S Mosebi, Y Sayed, J Burke, HW Dirr Biochemistry 42 (51), 15326-15332, 2003 | 31 | 2003 |
| Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors MM Makatini, K Petzold, PI Arvidsson, B Honarparvar, T Govender, ... European journal of medicinal chemistry 57, 459-467, 2012 | 26 | 2012 |
