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Tsan Sam Xiao
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Activation and regulation of the inflammasomes
E Latz, TS Xiao, A Stutz
Nature Reviews Immunology 13 (6), 397-411, 2013
32602013
IFI16 is an innate immune sensor for intracellular DNA
L Unterholzner, SE Keating, M Baran, KA Horan, SB Jensen, S Sharma, ...
Nature immunology 11 (11), 997-1004, 2010
18952010
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
T Xiao, J Takagi, BS Coller, JH Wang, TA Springer
Nature 432 (7013), 59-67, 2004
10332004
Structures of the αL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
M Shimaoka, T Xiao, JH Liu, Y Yang, Y Dong, CD Jun, A McCormack, ...
Cell 112 (1), 99-111, 2003
6382003
Structures of the HIN domain: DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
T Jin, A Perry, J Jiang, P Smith, JA Curry, L Unterholzner, Z Jiang, ...
Immunity 36 (4), 561-571, 2012
6112012
Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces
J Zhu, BH Luo, T Xiao, C Zhang, N Nishida, TA Springer
Molecular cell 32 (6), 849-861, 2008
6062008
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
JK Rathkey, J Zhao, Z Liu, Y Chen, J Yang, HC Kondolf, BL Benson, ...
Science immunology 3 (26), eaat2738, 2018
4792018
Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5, 6-dimethylxanthenone-4-acetic acid
J Conlon, DL Burdette, S Sharma, N Bhat, M Thompson, Z Jiang, ...
The Journal of Immunology 190 (10), 5216-5225, 2013
4412013
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
MR Jakobsen, RO Bak, A Andersen, RK Berg, SB Jensen, T Jin, ...
Proceedings of the National Academy of Sciences 110 (48), E4571-E4580, 2013
3902013
A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C
H Kato, J Jiang, BR Zhou, M Rozendaal, H Feng, R Ghirlando, TS Xiao, ...
Science 340 (6136), 1110-1113, 2013
3762013
Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin αIIbβ3
TA Springer, J Zhu, T Xiao
The Journal of cell biology 182 (4), 791-800, 2008
2802008
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
AM Herzner, CA Hagmann, M Goldeck, S Wolter, K Kübler, S Wittmann, ...
Nature immunology 16 (10), 1025-1033, 2015
2662015
Structural mechanisms of nucleosome recognition by linker histones
BR Zhou, J Jiang, H Feng, R Ghirlando, TS Xiao, Y Bai
Molecular cell 59 (4), 628-638, 2015
2622015
RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA
CM Sirois, T Jin, AL Miller, D Bertheloot, H Nakamura, GL Horvath, A Mian, ...
Journal of Experimental Medicine 210 (11), 2447-2463, 2013
2422013
Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity
C Zhou, X Chen, R Planells-Cases, J Chu, L Wang, L Cao, Z Li, ...
Immunity 52 (5), 767-781. e6, 2020
2292020
Post-translational regulation of inflammasomes
J Yang, Z Liu, TS Xiao
Cellular & molecular immunology 14 (1), 65-79, 2017
2082017
Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization
Z Liu, C Wang, J Yang, B Zhou, R Yang, R Ramachandran, DW Abbott, ...
Immunity 51 (1), 43-49. e4, 2019
2072019
Three-dimensional structure of a complex between the death domains of Pelle and Tube
T Xiao, P Towb, SA Wasserman, SR Sprang
Cell 99 (5), 545-555, 1999
2061999
The cGAS-STING pathway for DNA sensing
TS Xiao, KA Fitzgerald
Molecular cell 51 (2), 135-139, 2013
1882013
Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly
T Jin, A Perry, P Smith, J Jiang, TS Xiao
Journal of Biological Chemistry 288 (19), 13225-13235, 2013
1842013
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