| Artemisinins target the SERCA of Plasmodium falciparum U Eckstein-Ludwig, RJ Webb, IDA Van Goethem, JM East, AG Lee, ... Nature 424 (6951), 957-961, 2003 | 1371 | 2003 |
| Metabolism of fluorine-containing drugs BK Park, NR Kitteringham, PM O'Neill Annual review of pharmacology and toxicology 41 (1), 443-470, 2001 | 838 | 2001 |
| The molecular mechanism of action of artemisinin—the debate continues PM O’Neill, VE Barton, SA Ward Molecules 15 (3), 1705-1721, 2010 | 798 | 2010 |
| A medicinal chemistry perspective on artemisinin and related endoperoxides PM O'Neill, GH Posner Journal of medicinal chemistry 47 (12), 2945-2964, 2004 | 689 | 2004 |
| 4-Aminoquinolines—Past, present, and future; A chemical perspective PM O'Neill, PG Bray, SR Hawley, SA Ward, BK Park Pharmacology & therapeutics 77 (1), 29-58, 1998 | 403 | 1998 |
| Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 HM Ismail, V Barton, M Phanchana, S Charoensutthivarakul, MHL Wong, ... Proceedings of the National Academy of Sciences 113 (8), 2080-2085, 2016 | 298 | 2016 |
| Knowledge of the proposed chemical mechanism of action and cytochrome P450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial … GH Posner, PM O'Neill Accounts of chemical research 37 (6), 397-404, 2004 | 295 | 2004 |
| Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed BJ Stevenson, J Bibby, P Pignatelli, S Muangnoicharoen, PM O’Neill, ... Insect biochemistry and molecular biology 41 (7), 492-502, 2011 | 279 | 2011 |
| Evidence for the involvement of carbon-centered radicals in the induction of apoptotic cell death by artemisinin compounds AE Mercer, JL Maggs, XM Sun, GM Cohen, J Chadwick, PM O'Neill, ... Journal of Biological Chemistry 282 (13), 9372-9382, 2007 | 264 | 2007 |
| Relationship between Antimalarial Drug Activity, Accumulation, and Inhibition of Heme Polymerization in Plasmodium falciparum In Vitro SR Hawley, PG Bray, M Mungthin, JD Atkinson, PM O’Neill, SA Ward Antimicrobial agents and chemotherapy 42 (3), 682-686, 1998 | 233 | 1998 |
| Antimalarial pharmacology and therapeutics of atovaquone GL Nixon, DM Moss, AE Shone, DG Lalloo, N Fisher, PM O'Neill, SA Ward, ... Journal of Antimicrobial Chemotherapy 68 (5), 977-985, 2013 | 225 | 2013 |
| Quinolines and artemisinin: chemistry, biology and history PG Bray, SA Ward, PM O’neill Malaria: drugs, disease and post-genomic biology, 3-38, 2005 | 210 | 2005 |
| Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria GA Biagini, N Fisher, AE Shone, MA Mubaraki, A Srivastava, A Hill, ... Proceedings of the National Academy of Sciences 109 (21), 8298-8303, 2012 | 194 | 2012 |
| The role of heme and the mitochondrion in the chemical and molecular mechanisms of mammalian cell death induced by the artemisinin antimalarials AE Mercer, IM Copple, JL Maggs, PM O'Neill, BK Park Journal of Biological Chemistry 286 (2), 987-996, 2011 | 193 | 2011 |
| Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives K Amporndanai, X Meng, W Shang, Z Jin, M Rogers, Y Zhao, Z Rao, ... Nature communications 12 (1), 3061, 2021 | 191 | 2021 |
| Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials PM O'Neill, A Mukhtar, PA Stocks, LE Randle, S Hindley, SA Ward, ... Journal of medicinal chemistry 46 (23), 4933-4945, 2003 | 189 | 2003 |
| Novel Short Chain Chloroquine Analogues Retain Activity Against Chloroquine Resistant K1 Plasmodium falciparum PA Stocks, KJ Raynes, PG Bray, BK Park, PM O'Neill, SA Ward Journal of Medicinal Chemistry 45 (23), 4975-4983, 2002 | 180 | 2002 |
| Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs PA Stocks, PG Bray, VE Barton, M Al-Helal, M Jones, NC Araujo, ... Angewandte Chemie-International Edition 46 (33), 6278-6283, 2007 | 173 | 2007 |
| Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria GA Biagini, P Viriyavejakul, PM O'neill, PG Bray, SA Ward Antimicrobial agents and chemotherapy 50 (5), 1841-1851, 2006 | 171 | 2006 |
| Identification of a 1, 2, 4, 5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins PM O'Neill, RK Amewu, GL Nixon, F BousejraElGarah, M Mungthin, ... Angewandte Chemie-International Edition 49 (33), 5693, 2010 | 170 | 2010 |