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Dariusz Lachowski
Dariusz Lachowski
PhD, Department of Bioengineering, Imperial College London
Bestätigte E-Mail-Adresse bei imperial.ac.uk
Titel
Zitiert von
Zitiert von
Jahr
Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells
AJ Rice, E Cortes, D Lachowski, BCH Cheung, SA Karim, JP Morton, ...
Oncogenesis 6 (7), e352-e352, 2017
5492017
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
A Chronopoulos, B Robinson, M Sarper, E Cortes, V Auernheimer, ...
Nature communications 7 (1), 12630, 2016
2672016
FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis
D Lachowski, E Cortes, B Robinson, A Rice, K Rombouts, ...
The FASEB Journal 32 (2), 1099-1107, 2018
1902018
The guidance receptor plexin D1 is a mechanosensor in endothelial cells
V Mehta, KL Pang, D Rozbesky, K Nather, A Keen, D Lachowski, Y Kong, ...
Nature 578 (7794), 290-295, 2020
1742020
Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis
D Lachowski, E Cortes, A Rice, D Pinato, K Rombouts, ...
Scientific reports 9 (1), 7299, 2019
1462019
Substrate rigidity controls activation and durotaxis in pancreatic stellate cells
D Lachowski, E Cortes, D Pink, A Chronopoulos, SA Karim, J P. Morton, ...
Scientific reports 7 (1), 2506, 2017
1352017
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway
A Chronopoulos, SD Thorpe, E Cortes, D Lachowski, AJ Rice, ...
Nature materials 19 (6), 669-678, 2020
952020
Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival
E Cortes, D Lachowski, B Robinson, M Sarper, JS Teppo, SD Thorpe, ...
EMBO reports 20 (1), e46557, 2019
842019
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment
E Cortes, M Sarper, B Robinson, D Lachowski, A Chronopoulos, ...
EMBO reports 20 (1), e46556, 2019
762019
Mechanotransduction in talin through the interaction of the R8 domain with DLC1
AWM Haining, R Rahikainen, E Cortes, D Lachowski, A Rice, ...
PLoS biology 16 (7), e2005599, 2018
722018
Retinoic acid receptor‐β is downregulated in hepatocellular carcinoma and cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells
E Cortes, D Lachowski, A Rice, A Chronopoulos, B Robinson, S Thorpe, ...
Hepatology 69 (2), 785-802, 2019
67*2019
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor
E Cortes, D Lachowski, A Rice, SD Thorpe, B Robinson, G Yeldag, ...
Oncogene 38 (16), 2910-2922, 2019
622019
Substrate Stiffness-Driven Membrane Tension Modulates Vesicular Trafficking via Caveolin-1
D Lachowski, C Matellan, S Gopal, E Cortes, BK Robinson, A Saiani, ...
ACS nano 16 (3), 4322-4337, 2022
442022
GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA
A Rice, E Cortes, D Lachowski, P Oertle, C Matellan, SD Thorpe, R Ghose, ...
Cancers 12 (2), 289, 2020
242020
Self-assembling polypeptide hydrogels as a platform to recapitulate the tumor microenvironment
D Lachowski, C Matellan, E Cortes, A Saiani, AF Miller, ...
Cancers 13 (13), 3286, 2021
202021
Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto‐Active Substrates
C Gomez‐Cruz, M Fernandez‐de la Torre, D Lachowski, ...
Advanced Materials 36 (26), 2312497, 2024
152024
RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling
SJI Blackford, TL Tracy, MDA Norman, AM Syanda, M Manolakakis, ...
Biomaterials 293, 121982, 2023
152023
Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2
C Matellan, D Lachowski, E Cortes, KN Chiam, A Krstic, SD Thorpe, ...
Oncogenesis 12 (1), 23, 2023
142023
G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization
D Lachowski, E Cortes, C Matellan, A Rice, DA Lee, S Thorpe, ...
Frontiers in Cell and Developmental Biology 8, 1127, 2020
142020
Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi
S Yaganoglu, K Kalyviotis, C Vagena-Pantoula, D Jülich, BM Gaub, ...
nature communications 14 (1), 4352, 2023
112023
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