Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells AJ Rice, E Cortes, D Lachowski, BCH Cheung, SA Karim, JP Morton, ... Oncogenesis 6 (7), e352-e352, 2017 | 549 | 2017 |
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion A Chronopoulos, B Robinson, M Sarper, E Cortes, V Auernheimer, ... Nature communications 7 (1), 12630, 2016 | 267 | 2016 |
FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis D Lachowski, E Cortes, B Robinson, A Rice, K Rombouts, ... The FASEB Journal 32 (2), 1099-1107, 2018 | 190 | 2018 |
The guidance receptor plexin D1 is a mechanosensor in endothelial cells V Mehta, KL Pang, D Rozbesky, K Nather, A Keen, D Lachowski, Y Kong, ... Nature 578 (7794), 290-295, 2020 | 174 | 2020 |
Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis D Lachowski, E Cortes, A Rice, D Pinato, K Rombouts, ... Scientific reports 9 (1), 7299, 2019 | 146 | 2019 |
Substrate rigidity controls activation and durotaxis in pancreatic stellate cells D Lachowski, E Cortes, D Pink, A Chronopoulos, SA Karim, J P. Morton, ... Scientific reports 7 (1), 2506, 2017 | 135 | 2017 |
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway A Chronopoulos, SD Thorpe, E Cortes, D Lachowski, AJ Rice, ... Nature materials 19 (6), 669-678, 2020 | 95 | 2020 |
Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival E Cortes, D Lachowski, B Robinson, M Sarper, JS Teppo, SD Thorpe, ... EMBO reports 20 (1), e46557, 2019 | 84 | 2019 |
GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment E Cortes, M Sarper, B Robinson, D Lachowski, A Chronopoulos, ... EMBO reports 20 (1), e46556, 2019 | 76 | 2019 |
Mechanotransduction in talin through the interaction of the R8 domain with DLC1 AWM Haining, R Rahikainen, E Cortes, D Lachowski, A Rice, ... PLoS biology 16 (7), e2005599, 2018 | 72 | 2018 |
Retinoic acid receptor‐β is downregulated in hepatocellular carcinoma and cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells E Cortes, D Lachowski, A Rice, A Chronopoulos, B Robinson, S Thorpe, ... Hepatology 69 (2), 785-802, 2019 | 67* | 2019 |
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor E Cortes, D Lachowski, A Rice, SD Thorpe, B Robinson, G Yeldag, ... Oncogene 38 (16), 2910-2922, 2019 | 62 | 2019 |
Substrate Stiffness-Driven Membrane Tension Modulates Vesicular Trafficking via Caveolin-1 D Lachowski, C Matellan, S Gopal, E Cortes, BK Robinson, A Saiani, ... ACS nano 16 (3), 4322-4337, 2022 | 44 | 2022 |
GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA A Rice, E Cortes, D Lachowski, P Oertle, C Matellan, SD Thorpe, R Ghose, ... Cancers 12 (2), 289, 2020 | 24 | 2020 |
Self-assembling polypeptide hydrogels as a platform to recapitulate the tumor microenvironment D Lachowski, C Matellan, E Cortes, A Saiani, AF Miller, ... Cancers 13 (13), 3286, 2021 | 20 | 2021 |
Mechanical and Functional Responses in Astrocytes under Alternating Deformation Modes Using Magneto‐Active Substrates C Gomez‐Cruz, M Fernandez‐de la Torre, D Lachowski, ... Advanced Materials 36 (26), 2312497, 2024 | 15 | 2024 |
RGD density along with substrate stiffness regulate hPSC hepatocyte functionality through YAP signalling SJI Blackford, TL Tracy, MDA Norman, AM Syanda, M Manolakakis, ... Biomaterials 293, 121982, 2023 | 15 | 2023 |
Retinoic acid receptor β modulates mechanosensing and invasion in pancreatic cancer cells via myosin light chain 2 C Matellan, D Lachowski, E Cortes, KN Chiam, A Krstic, SD Thorpe, ... Oncogenesis 12 (1), 23, 2023 | 14 | 2023 |
G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization D Lachowski, E Cortes, C Matellan, A Rice, DA Lee, S Thorpe, ... Frontiers in Cell and Developmental Biology 8, 1127, 2020 | 14 | 2020 |
Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi S Yaganoglu, K Kalyviotis, C Vagena-Pantoula, D Jülich, BM Gaub, ... nature communications 14 (1), 4352, 2023 | 11 | 2023 |