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Ly Porosk
Ly Porosk
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New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids
P Arukuusk, L Pärnaste, N Oskolkov, DM Copolovici, H Margus, K Padari, ...
Biochimica et Biophysica Acta (BBA)-Biomembranes 1828 (5), 1365-1373, 2013
982013
The formation of nanoparticles between small interfering RNA and amphipathic cell-penetrating peptides
L Pärnaste, P Arukuusk, K Langel, T Tenson, Ü Langel
Molecular Therapy-Nucleic Acids 7, 1-10, 2017
572017
Effective in vivo gene delivery with reduced toxicity, achieved by charge and fatty acid -modified cell penetrating peptide
K Kurrikoff, KL Veiman, K Künnapuu, EM Peets, T Lehto, L Pärnaste, ...
Scientific reports 7 (1), 17056, 2017
432017
Effects of cargo molecules on membrane perturbation caused by transportan10 based cell-penetrating peptides
L Vasconcelos, F Madani, P Arukuusk, L Pärnaste, A Gräslund, Ü Langel
Biochimica et Biophysica Acta (BBA)-Biomembranes 1838 (12), 3118-3129, 2014
382014
Enhancement of siRNA transfection by the optimization of fatty acid length and histidine content in the CPP
L Porosk, P Arukuusk, K Põhako, K Kurrikoff, K Kiisholts, K Padari, ...
Biomaterials science 7 (10), 4363-4374, 2019
352019
Tumor gene therapy by systemic delivery of plasmid DNA with cell‐penetrating peptides
K Künnapuu, KL Veiman, L Porosk, E Rammul, K Kiisholts, Ü Langel, ...
Faseb Bioadvances 1 (2), 105, 2018
342018
PepFects and NickFects for the intracellular delivery of nucleic acids
P Arukuusk, L Pärnaste, M Hällbrink, Ü Langel
Cell-Penetrating Peptides: Methods and Protocols, 303-315, 2015
342015
Approaches for the discovery of new cell-penetrating peptides
L Porosk, I Gaidutšik, Ü Langel
Expert Opinion on Drug Discovery 16 (5), 553-565, 2021
272021
Formulation of stable and homogeneous cell-penetrating peptide NF55 nanoparticles for efficient gene delivery in vivo
K Freimann, P Arukuusk, K Kurrikoff, L Pärnaste, R Raid, A Piirsoo, ...
Molecular Therapy-Nucleic Acids 10, 28-35, 2018
252018
Amyloid-like self-assembly of a hydrophobic cell-penetrating peptide and its use as a carrier for nucleic acids
LR de Mello, L Porosk, TC Lourenço, BBM Garcia, CAR Costa, SW Han, ...
ACS Applied Bio Materials 4 (8), 6404-6416, 2021
222021
Cell-penetrating peptide and siRNA-mediated therapeutic effects on endometriosis and cancer in vitro models
K Kiisholts, K Kurrikoff, P Arukuusk, L Porosk, M Peters, A Salumets, ...
Pharmaceutics 13 (10), 1618, 2021
182021
Methods to follow intracellular trafficking of cell-penetrating peptides
L Pärnaste, P Arukuusk, E Zagato, K Braeckmans, Ü Langel
Journal of Drug Targeting 24 (6), 508-519, 2016
182016
Approaches for evaluation of novel CPP-based cargo delivery systems
L Porosk, Ü Langel
Frontiers in Pharmacology 13, 1056467, 2022
132022
The development of cell-penetrating peptides for efficient and selective in vivo expression of mRNA in spleen tissue
L Porosk, HH Härk, P Arukuusk, U Haljasorg, P Peterson, K Kurrikoff
Pharmaceutics 15 (3), 952, 2023
112023
Predicting transiently expressed protein yields: Comparison of transfection methods in CHO and HEK293
L Porosk, J Nebogatova, HH Härk, B Vunk, P Arukuusk, U Toots, M Ustav, ...
Pharmaceutics 14 (9), 1949, 2022
102022
Modification of the linker amino acid in the cell-penetrating peptide NickFect55 leads to enhanced pDNA transfection for in vivo applications
HH Härk, L Porosk, LR de Mello, P Arukuusk, ER da Silva, K Kurrikoff
Pharmaceutics 15 (3), 883, 2023
42023
Aggregation limiting cell-penetrating peptides derived from protein signal sequences
L Porosk, HH Härk, RN Bicev, I Gaidutšik, J Nebogatova, EJ Armolik, ...
International Journal of Molecular Sciences 24 (5), 4277, 2023
42023
Cell-penetrating peptides predicted from CASC3, AKIP1, and AHRR proteins
L Porosk, K Põhako, P Arukuusk, Ü Langel
Frontiers in Pharmacology 12, 716226, 2021
32021
Characterization of Peptide–Oligonucleotide Complexes Using Electron Microscopy, Dynamic Light Scattering, and Protease Resistance Assay
K Padari, L Porosk, P Arukuusk, M Pooga
Oligonucleotide-Based Therapies: Methods and Protocols, 127-139, 2019
32019
Endpoint and kinetic approaches for assessing transfection efficacy in mammalian cell culture
L Porosk, J Nebogatova, I Gaidutšik, Ü Langel
Cell Penetrating Peptides: Methods and Protocols, 529-545, 2022
22022
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