| The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases (∗) JM Whitelock, AD Murdoch, RV Iozzo, PA Underwood Journal of Biological Chemistry 271 (17), 10079-10086, 1996 | 803 | 1996 |
| Heparan sulfate: a complex polymer charged with biological activity JM Whitelock, RV Iozzo Chemical reviews 105 (7), 2745-2764, 2005 | 536 | 2005 |
| Diverse cell signaling events modulated by perlecan JM Whitelock, J Melrose, RV Iozzo Biochemistry 47 (43), 11174-11183, 2008 | 324 | 2008 |
| Oxidative damage to extracellular matrix and its role in human pathologies MD Rees, EC Kennett, JM Whitelock, MJ Davies Free Radical Biology and Medicine 44 (12), 1973-2001, 2008 | 287 | 2008 |
| Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. B Sharma, M Handler, I Eichstetter, JM Whitelock, MA Nugent, RV Iozzo The Journal of clinical investigation 102 (8), 1599-1608, 1998 | 253 | 1998 |
| CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan C Vennin, P Mélénec, R Rouet, M Nobis, AS Cazet, KJ Murphy, ... Nature communications 10 (1), 3637, 2019 | 231 | 2019 |
| Perlecan: how does one molecule do so many things? SM Knox, JM Whitelock Cellular and Molecular Life Sciences CMLS 63, 2435-2445, 2006 | 209 | 2006 |
| Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors S Knox, C Merry, S Stringer, J Melrose, J Whitelock Journal of Biological Chemistry 277 (17), 14657-14665, 2002 | 200 | 2002 |
| Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis VN Patel, SM Knox, KM Likar, CA Lathrop, R Hossain, S Eftekhari, ... Oxford University Press for The Company of Biologists Limited 134 (23), 4177 …, 2007 | 195 | 2007 |
| The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7 M Mongiat, K Taylor, J Otto, S Aho, J Uitto, JM Whitelock, RV Iozzo Journal of Biological Chemistry 275 (10), 7095-7100, 2000 | 186 | 2000 |
| Cancer metastasis: the role of the extracellular matrix and the heparan sulfate proteoglycan perlecan Z Elgundi, M Papanicolaou, G Major, TR Cox, J Melrose, JM Whitelock, ... Frontiers in oncology 9, 1482, 2020 | 172 | 2020 |
| Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study J Melrose, S Smith, M Cake, R Read, J Whitelock Histochemistry and cell biology 124, 225-235, 2005 | 165 | 2005 |
| The modulation of platelet adhesion and activation by chitosan through plasma and extracellular matrix proteins MS Lord, B Cheng, SJ McCarthy, MS Jung, JM Whitelock Biomaterials 32 (28), 6655-6662, 2011 | 163 | 2011 |
| Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells JM Whitelock, LD Graham, J Melrose, AD Murdoch, RV Iozzo, ... Matrix biology 18 (2), 163-178, 1999 | 162 | 1999 |
| Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis JJ Zoeller, JM Whitelock, RV Iozzo Matrix Biology 28 (5), 284-291, 2009 | 150 | 2009 |
| The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling MS Lord, CY Chuang, J Melrose, MJ Davies, RV Iozzo, JM Whitelock Matrix Biology 35, 112-122, 2014 | 146 | 2014 |
| Structural and functional characterisation of poly (vinyl alcohol) and heparin hydrogels A Nilasaroya, LA Poole-Warren, JM Whitelock, PJ Martens Biomaterials 29 (35), 4658-4664, 2008 | 145 | 2008 |
| A central function for perlecan in skeletal muscle and cardiovascular development JJ Zoeller, A McQuillan, J Whitelock, SY Ho, RV Iozzo The Journal of cell biology 181 (2), 381-394, 2008 | 141 | 2008 |
| The effect of silica nanoparticulate coatings on serum protein adsorption and cellular response MS Lord, BG Cousins, PJ Doherty, JM Whitelock, A Simmons, RL Williams, ... Biomaterials 27 (28), 4856-4862, 2006 | 141 | 2006 |
| Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M (r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast … JG Lyons, B Birkedal-Hansen, MC Pierson, JM Whitelock, ... Journal of Biological Chemistry 268 (25), 19143-19151, 1993 | 140 | 1993 |